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UniProtKB/Swiss-Prot entry Q12926


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name ELAV2_HUMAN
Primary accession number Q12926
Secondary accession numbers Q13235 Q59G15 Q8NEM4 Q9H1Q8
Integrated into Swiss-Prot on February 21, 2001
Sequence was last modified on April 18, 2006 (Sequence version 2)
Annotations were last modified on    May 5, 2009 (Entry version 76)
Name and origin of the protein
Protein name ELAV-like protein 2
Synonyms Hu-antigen B
HuB
ELAV-like neuronal protein 1
Nervous system-specific RNA-binding protein Hel-N1
Gene name
Name: ELAVL2
Synonyms: HUB
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
TISSUE=Brain;
PubMed=8158249 [NCBI, ExPASy, EBI, Israel, Japan]
King P.H., Levine T.D., Fremeau R.T. Jr., Keene J.D.;
"Mammalian homologs of Drosophila ELAV localized to a neuronal subset can bind in vitro to the 3' UTR of mRNA encoding the Id transcriptional repressor.";
J. Neurosci. 14:1943-1952(1994).
[2]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
TISSUE=Medulloblastoma;
DOI=10.1073/pnas.91.23.11207; PubMed=7972035 [NCBI, ExPASy, EBI, Israel, Japan]
Gao F.B., Carson C.C., Levine T., Keene J.D.;
"Selection of a subset of mRNAs from combinatorial 3' untranslated region libraries using neuronal RNA-binding protein Hel-N1.";
Proc. Natl. Acad. Sci. U.S.A. 91:11207-11211(1994).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Brain;
Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., Ohara O., Nagase T., Kikuno R.F.;
Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1038/nature02465; PubMed=15164053 [NCBI, ExPASy, EBI, Israel, Japan]
Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.;
"DNA sequence and analysis of human chromosome 9.";
Nature 429:369-374(2004).
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
TISSUE=Testis;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[6]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-221, AND MASS SPECTROMETRY.
DOI=10.1073/pnas.0805139105; PubMed=18669648 [NCBI, ExPASy, EBI, Israel, Japan]
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.;
"A quantitative atlas of mitotic phosphorylation.";
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
U12431; AAA69698.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
U29943; AAA70417.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AB209294; BAD92531.1; ALT_INIT; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL161628; CAI13376.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL445623; CAI13376.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL161628; CAC22160.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC030692; AAH30692.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
IPI IPI00030250; -.
IPI00219967; -.
PIR I38726; I38726.
I39077; I39077.
RefSeq NP_004423.2; -.
UniGene Hs.166109
3D structure databases
HSSP P26378; 1FXL. [HSSP ENTRY / PDB]
SMR Q12926; 37-203.
ModBase Q12926.
PTM databases
PhosphoSite Q12926; -.
Organism-specific databases
GeneCards GC09M023680; -.
H-InvDB HIX0007958; -.
HGNC HGNC:3313; ELAVL2.
GenAtlas ELAVL2.
MIM 601673; gene. [NCBI / EBI]
PharmGKB PA27741; -.
Gene expression databases
ArrayExpress Q12926; -.
Bgee Q12926; -.
CleanEx HS_ELAVL2; -.
GermOnline ENSG00000107105; Homo sapiens.
Ontologies
GO
GO:0003730; Molecular function: mRNA 3'-UTR binding (traceable author statement from ProtInc).
GO:0000166; Molecular function: nucleotide binding (inferred from electronic annotation from InterPro).
GO:0006355; Biological process: regulation of transcription, DNA-dependent (traceable author statement from ProtInc).
QuickGo view.
Family and domain databases
InterPro IPR012677; a_b_plait_nuc_bd.
IPR006548; ELAD_HUD_SF.
IPR002343; Hud_Sxl_RNA.
IPR000504; RRM_RNP1.
Graphical view of domain structure.
Gene3D G3DSA:3.30.70.330; a_b_plait_nuc_bd; 3.
Pfam PF00076; RRM_1; 3.
Pfam graphical view of domain structure.
PRINTS PR00961; HUDSXLRNA.
SMART SM00360; RRM; 3.
SMART graphical view of domain structure.
TIGRFAMs TIGR01661; ELAV_HUD_SF; 1.
PROSITE PS50102; RRM; 3.
PROSITE graphical view of domain structure (profiles).
Proteomic databases
PRIDE Q12926; -.
Genome annotation databases
Ensembl ENSG00000107105; Homo sapiens. [Contig view]
GeneID 1993; -.
KEGG hsa:1993; -.
Phylogenomic databases
HOVERGEN Q12926; -.
Other
NextBio 8059; -.
SOURCE ELAVL2; Homo sapiens.
ProtoNet Q12926.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Alternative splicing; Phosphoprotein; Repeat; RNA-binding.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   359  359     ELAV-like protein 2. PRO_0000081579
DOMAIN   39   117  79     RRM 1. 
DOMAIN   125   205  81     RRM 2. 
DOMAIN   276   354  79     RRM 3. 
MOD_RES   221   221        Phosphoserine. 
VAR_SEQ   239   251        Missing (in isoform 2). VSP_005788
CONFLICT   335   335        A -> R (in Ref. 1 and 2). 
Sequence information
Length: 359 AA [This is the length of the unprocessed precursor] Molecular weight: 39504 Da [This is the MW of the unprocessed precursor] CRC64: 15E87088FC546DDC [This is a checksum on the sequence]
        10         20         30         40         50         60 
METQLSNGPT CNNTANGPTT INNNCSSPVD SGNTEDSKTN LIVNYLPQNM TQEELKSLFG 

        70         80         90        100        110        120 
SIGEIESCKL VRDKITGQSL GYGFVNYIDP KDAEKAINTL NGLRLQTKTI KVSYARPSSA 

       130        140        150        160        170        180 
SIRDANLYVS GLPKTMTQKE LEQLFSQYGR IITSRILVDQ VTGISRGVGF IRFDKRIEAE 

       190        200        210        220        230        240 
EAIKGLNGQK PPGATEPITV KFANNPSQKT NQAILSQLYQ SPNRRYPGPL AQQAQRFRLD 

       250        260        270        280        290        300 
NLLNMAYGVK RFSPMTIDGM TSLAGINIPG HPGTGWCIFV YNLAPDADES ILWQMFGPFG 

       310        320        330        340        350 
AVTNVKVIRD FNTNKCKGFG FVTMTNYDEA AMAIASLNGY RLGDRVLQVS FKTNKTHKA 

Q12926 in FASTA format

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