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UniProtKB/Swiss-Prot entry Q11119


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name UBP14_SCHPO
Primary accession number Q11119
Secondary accession numbers None
Integrated into Swiss-Prot on November 1, 2002
Sequence was last modified on August 1, 1999 (Sequence version 2)
Annotations were last modified on    November 25, 2008 (Entry version 69)
Name and origin of the protein
Protein name Ubiquitin carboxyl-terminal hydrolase 14
Synonyms EC 3.1.2.15
Ubiquitin thioesterase 14
Ubiquitin-specific-processing protease 14
Deubiquitinating enzyme 14
UBA domain-containing protein 2
Gene name
Name: ubp14
Synonyms: ucp2
ORFNames: SPBC6B1.06c
From
Schizosaccharomyces pombe (Fission yeast) [TaxID: 4896] 
Taxonomy Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 38366 / 972;
DOI=10.1038/nature724; PubMed=11859360 [NCBI, ExPASy, EBI, Israel, Japan]
Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M., Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.;
"The genome sequence of Schizosaccharomyces pombe.";
Nature 415:871-880(2002).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-386.
Okazaki K., Okayama H.;
"Fission yeast TPR gene involved in G0 transition.";
Submitted (FEB-1996) to the EMBL/GenBank/DDBJ databases.
[3]
IDENTIFICATION.
DOI=10.1038/ncb1001-939; PubMed=11584278 [NCBI, ExPASy, EBI, Israel, Japan]
Wilkinson C.R.M., Seeger M., Hartmann-Petersen R., Stone M., Wallace M., Semple C., Gordon C.;
"Proteins containing the UBA domain are able to bind to multi-ubiquitin chains.";
Nat. Cell Biol. 3:939-943(2001).
[4]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-456, AND MASS SPECTROMETRY.
DOI=10.1021/pr7006335; PubMed=18257517 [NCBI, ExPASy, EBI, Israel, Japan]
Wilson-Grady J.T., Villen J., Gygi S.P.;
"Phosphoproteome analysis of fission yeast.";
J. Proteome Res. 7:1088-1097(2008).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
CU329671; CAA17049.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
D83659; BAA12032.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR T40647; T40647.
RefSeq NP_596085.1; -.
3D structure databases
HSSP Q93009; 1NB8. [HSSP ENTRY / PDB]
ModBase Q11119.
Protein family/group databases
MEROPS C19.083; -.
Enzyme and pathway databases
BioCyc SPOM-XXX-01:SPOM-XXX-01-004129-MON; -.
Organism-specific databases
GeneDB_Spombe SPBC6B1.06c; -.
Gene expression databases
ArrayExpress Q11119; -.
Ontologies
GO
GO:0005829; Cellular component: cytosol (inferred from direct assay from GeneDB_SPombe).
GO:0005634; Cellular component: nucleus (inferred from direct assay from GeneDB_SPombe).
GO:0031593; Molecular function: polyubiquitin binding (traceable author statement from GeneDB_SPombe).
GO:0004221; Molecular function: ubiquitin thiolesterase activity (inferred from electronic annotation from InterPro).
GO:0008270; Molecular function: zinc ion binding (inferred from electronic annotation from InterPro).
GO:0043161; Biological process: proteasomal ubiquitin-dependent protein catabolic process (traceable author statement from GeneDB_SPombe).
QuickGo view.
Family and domain databases
InterPro IPR001394; Peptidase_C19.
IPR000449; UBA/transl_elong_EF1B_N.
IPR015940; UBA/transl_elong_EF1B_N_euk.
IPR016652; Ubiquitinyl_hydrolase.
IPR001607; Znf_UBP.
Graphical view of domain structure.
Pfam PF00627; UBA; 2.
PF00443; UCH; 1.
PF02148; zf-UBP; 2.
Pfam graphical view of domain structure.
PIRSF PIRSF016308; UBP; 1.
SMART SM00165; UBA; 2.
SM00290; ZnF_UBP; 2.
SMART graphical view of domain structure.
PROSITE PS50030; UBA; 2.
PS00972; UCH_2_1; 1.
PS00973; UCH_2_2; 1.
PS50235; UCH_2_3; 1.
PS50271; ZF_UBP; 2.
PROSITE graphical view of domain structure (profiles).
ProtoNet Q11119.
Genome annotation databases
GeneID 2541157; -.
KEGG spo:SPBC6B1.06c; -.
NMPDR fig|4896.1.peg.1951; -.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; Hydrolase; Metal-binding; Phosphoprotein; Protease; Repeat; Thiol protease; Ubl conjugation pathway; Zinc; Zinc-finger.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   775  775     Ubiquitin carboxyl-terminal hydrolase 14. PRO_0000080613
DOMAIN   576   617  42     UBA 1. 
DOMAIN   639   679  41     UBA 2. 
ZN_FING   26    91  66     UBP-type 1. 
ZN_FING   172   245  74     UBP-type 2. 
ACT_SITE   309   309        By similarity. 
ACT_SITE   721   721        By similarity. 
ACT_SITE   730   730        By similarity. 
MOD_RES   456   456        Phosphoserine. 
Sequence information
Length: 775 AA [This is the length of the unprocessed precursor] Molecular weight: 86783 Da [This is the MW of the unprocessed precursor] CRC64: EFF8942E925CF7C0 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MSCPHLTETN VVIPDNSQVI YREECVRCFN SQDEEGGIDL CLTCFQSGCG ETGLKHSLVH 

        70         80         90        100        110        120 
FEQTLHPIVV TIARQPKQKI NDEPPQKITK LEIREDSDED LYDYFYVPKC LVCNIILDIQ 

       130        140        150        160        170        180 
DPLLSLSLEA MKNATKASNK SQLTAWENEL TTCDHIINLP ENETYVTNLD NATCSKCDLA 

       190        200        210        220        230        240 
ENLWMCLTCG ALSCGRKQYG GGGGNGHALS HYDDTGHPLA VKLKSISPDG QADIYCYSCD 

       250        260        270        280        290        300 
EERIDPNIKT HMLNFGIDIA KLNKTEKSLA ELQLEQNLNW DFGASEEDDA SKRLFGPGLT 

       310        320        330        340        350        360 
GLKNLGNSCY LASTMQSLFS IKEFAIHELN LFNTYNSVCQ TPTTDLQCQL GKLADGLVSG 

       370        380        390        400        410        420 
KFSKPSKIGL LNNPSSSILP YQDGLRPFMF KDVVGQGHSE FGTSQQQDAY EFLLYLLGKI 

       430        440        450        460        470        480 
RKSSIAKTDI TKIFDFETEQ KLSCLSCKRV RYSSFSSQGL TLTVPRVKIG EIEGEQIYEE 

       490        500        510        520        530        540 
VSIDQCLDAT IQPDQMEYTC EACKSKLGAT TTTAMKSFPK VLILQANRFD LQGYQVKKLS 

       550        560        570        580        590        600 
IPIIVNEDGI YNFDRLMAKD HPNDEDYLPE KTETIEWNQS AIEQLQAMGF PLVRCQRALL 

       610        620        630        640        650        660 
ATGNSDTETA MNWLFEHMED PEIDKPIEVS ELLPKADSSV SEENVQSLCE FGFTVAQARK 

       670        680        690        700        710        720 
GLLESNNNIE RAVDWILNHP DESFEEPPLE GSDSSIKNEN MGSWESTNVP VNYNLKAIIS 

       730        740        750        760        770 
HKGSSAHAGH YVAFIRKEID GKQQWVLFND EKVLQVASLE EAKTTGYVYL FERLD 

Q11119 in FASTA format

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