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UniProtKB/Swiss-Prot entry Q10761


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name FRDB_MYCTU
Primary accession number Q10761
Secondary accession numbers None
Integrated into Swiss-Prot on October 1, 1996
Sequence was last modified on October 1, 1996 (Sequence version 1)
Annotations were last modified on    September 2, 2008 (Entry version 65)
Name and origin of the protein
Protein name Fumarate reductase iron-sulfur subunit
Synonym EC 1.3.99.1
Gene name
Name: frdB
OrderedLocusNames: Rv1553, MT1604
ORFNames: MTCY48.12c
From
Mycobacterium tuberculosis [TaxID: 1773] [HAMAP proteome]
Taxonomy Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales; Corynebacterineae; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex.
Protein existence 3: Inferred from homology;
References
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 25618 / H37Rv;
DOI=10.1038/31159; PubMed=9634230 [NCBI, ExPASy, EBI, Israel, Japan]
Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E., Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K., Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K., Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K., Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J., Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S., Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S., Barrell B.G.;
"Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.";
Nature 393:537-544(1998).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=CDC 1551 / Oshkosh;
DOI=10.1128/JB.184.19.5479-5490.2002; PubMed=12218036 [NCBI, ExPASy, EBI, Israel, Japan]
Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O., Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K., Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L., Delcher A., Utterback T.R., Weidman J.F., Khouri H.M., Gill J., Mikula A., Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M.;
"Whole-genome comparison of Mycobacterium tuberculosis clinical and laboratory strains.";
J. Bacteriol. 184:5479-5490(2002).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
BX842577; CAA98310.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AE000516; AAK45871.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR F70762; F70762.
RefSeq NP_216069.1; -.
NP_336057.1; -.
3D structure databases
HSSP P00364; 1KF6. [HSSP ENTRY / PDB]
ModBase Q10761.
Organism-specific databases
TubercuList Rv1553; -.
Family and domain databases
InterPro IPR006058; 2Fe2S_fd_BS.
IPR001450; 4Fe4S_Fe_S_bd.
IPR012675; b-grasp_ferredoxin-like.
IPR001041; Ferredoxin.
IPR012285; Fum_reductase_C.
IPR004489; Succ_DHase/fum_Rdtase_Fe-S.
Graphical view of domain structure.
Gene3D G3DSA:3.10.20.30; Ferredoxin_fold; 1.
G3DSA:1.10.1060.10; Fum_reductase_C; 1.
Pfam PF00037; Fer4; 1.
Pfam graphical view of domain structure.
TIGRFAMs TIGR00384; dhsB; 1.
PROSITE PS00197; 2FE2S_FER_1; FALSE_NEG.
PS51085; 2FE2S_FER_2; FALSE_NEG.
PS00198; 4FE4S_FER_1; 1.
PS51379; 4FE4S_FER_2; 1.
PROSITE graphical view of domain structure (profiles).
BLOCKS Q10761.
Genome annotation databases
GeneID 886378; -.
924333; -.
GenomeReviews AE000516_GR; MT1604.
AL123456_GR; Rv1553.
KEGG mtc:MT1604; -.
mtu:Rv1553; -.
TIGR MT1604; -.
Phylogenomic databases
HOGENOM Q10761; -.
Other
ProtoNet Q10761.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
2Fe-2S; 3Fe-4S; 4Fe-4S; Complete proteome; Electron transport; Iron; Iron-sulfur; Metal-binding; Oxidoreductase; Transport; Tricarboxylic acid cycle.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   247  247     Fumarate reductase iron-sulfur subunit. PRO_0000158705
DOMAIN   14    94  81     2Fe-2S ferredoxin-type. 
DOMAIN   140   169  30     4Fe-4S ferredoxin-type. 
METAL   56    56        Iron-sulfur 1 (2Fe-2S) (By similarity). 
METAL   61    61        Iron-sulfur 1 (2Fe-2S) (By similarity). 
METAL   76    76        Iron-sulfur 1 (2Fe-2S) (By similarity). 
METAL   149   149        Iron-sulfur 2 (4Fe-4S) (By similarity). 
METAL   152   152        Iron-sulfur 2 (4Fe-4S) (By similarity). 
METAL   155   155        Iron-sulfur 2 (4Fe-4S) (By similarity). 
METAL   159   159        Iron-sulfur 3 (3Fe-4S) (By similarity). 
METAL   205   205        Iron-sulfur 3 (3Fe-4S) (By similarity). 
METAL   211   211        Iron-sulfur 3 (3Fe-4S) (By similarity). 
METAL   215   215        Iron-sulfur 2 (4Fe-4S) (By similarity). 
Sequence information
Length: 247 AA [This is the length of the unprocessed precursor] Molecular weight: 27234 Da [This is the MW of the unprocessed precursor] CRC64: 15863DCCB2C82B0B [This is a checksum on the sequence]
        10         20         30         40         50         60 
MMDRIVMEVS RYRPEIESAP TFQAYEVPLT REWAVLDGLT YIKDHLDGTL SFRWSCRMGI 

        70         80         90        100        110        120 
CGSSGMTING DPKLACATFL ADYLPGPVRV EPMRNFPVIR DLVVDISDFM AKLPSVKPWL 

       130        140        150        160        170        180 
VRHDEPPVED GEYRQTPAEL DAFKQFSMCI NCMLCYSACP VYALDPDFLG PAAIALGQRY 

       190        200        210        220        230        240 
NLDSRDQGAA DRRDVLAAAD GAWACTLVGE CSTACPKGVD PAGAIQRYKL TAATHALKKL 


LFPWGGG 

Q10761 in FASTA format

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