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- FUNCTION: Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form. Responsible for the proteolytic release of several other cell-surface proteins, including heparin-binding epidermal growth-like factor, ephrin-A2 and for constitutive and regulated alpha-secretase cleavage of amyloid precursor protein (APP). Contributes to the normal cleavage of the cellular prion protein. Involved in the cleavage of the adhesion molecule L1 at the cell surface and in released membrane vesicles, suggesting a vesicle-based protease activity. Controls also the proteolytic processing of Notch (By similarity).
- CATALYTIC ACTIVITY: Endopeptidase of broad specificity.
- COFACTOR: Binds 1 zinc ion (By similarity).
- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
- TISSUE SPECIFICITY: Expressed in brain, kidney, lung, spleen, ovary and testis.
- PTM: The precursor is cleaved by a furin endopeptidase (By similarity).
- SIMILARITY: Contains 1 disintegrin domain.
- SIMILARITY: Contains 1 peptidase M12B domain [view classification].
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Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms.
Distributed under the Creative Commons Attribution-NoDerivs License.
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| Length: 544 AA [This is the length of the partial sequence of the unprocessed precursor] |
Molecular weight: 60445 Da [This is the MW of the partial sequence of the unprocessed precursor] |
CRC64: F75E0E8D6C88A7DD [This is a checksum on the sequence] |
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10 20 30 40 50 60
GPELLRKKRT TLPERNTCQL YIQTDHLFFK SYGTREAVIA QISSHVKAID AIYQTTDFSG
70 80 90 100 110 120
IRNISFMVKR IRINTTSDEK DPTNPFRFPN IGVEKFLELN SEQNHDDYCL AYVFTDRDFD
130 140 150 160 170 180
DGVLGLAWVG APSGSSGGIC EKSKLYSDGK KKSLNTGIIT VQNYGSHVPP KVSHITFAHE
190 200 210 220 230 240
VGHNFGSPHD SGTECTPGES KNLGQKENGN YIMYARATSG DKLNNNKFSL CSIRNISQVL
250 260 270 280 290 300
EKKRNNCFVE SGQPICGNGM VEQGEECDCG YSDQCKDECC FDANQPEGKK CKLKPGKQCS
310 320 330 340 350 360
PSQGPCCTAQ CAFKSKSEKC RDDSDCAKEG ICNGFTALCP ASDPKPNFTD CNRHTQVCIN
370 380 390 400 410 420
GQCAGSICEK YDLEECTCAS SDGKDDKELC HVCCMKKMAP STCASTGSLQ WNKQFTGRTI
430 440 450 460 470 480
TLQPGSPCND FRGYCDVFMR CRLVDADGPL ARLKKAIFSP QLYENIAEWI VAHWWAVLLM
490 500 510 520 530 540
GIALIMLMAG FIKICSVHTP SSNPKLPPPK PLPGTLKRRR PPQPIQQPQR QRPRESYQMG
HMRR
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Q10743 in FASTA format |
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