|
|
|
|
|
|
[1]
|
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 25618 / H37Rv;
DOI=10.1038/31159; PubMed=9634230 [NCBI, ExPASy, EBI, Israel, Japan]
Cole S.T.,
Brosch R.,
Parkhill J.,
Garnier T.,
Churcher C.M.,
Harris D.E.,
Gordon S.V.,
Eiglmeier K.,
Gas S.,
Barry C.E. III,
Tekaia F.,
Badcock K.,
Basham D.,
Brown D.,
Chillingworth T.,
Connor R.,
Davies R.M.,
Devlin K.,
Feltwell T., ![]()
Gentles S.,
Hamlin N.,
Holroyd S.,
Hornsby T.,
Jagels K.,
Krogh A.,
McLean J.,
Moule S.,
Murphy L.D.,
Oliver S.,
Osborne J.,
Quail M.A.,
Rajandream M.A.,
Rogers J.,
Rutter S.,
Seeger K.,
Skelton S.,
Squares S.,
Squares R.,
Sulston J.E.,
Taylor K.,
Whitehead S.,
Barrell B.G.;
"Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.";
Nature 393:537-544(1998).
|
[2]
|
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=CDC 1551 / Oshkosh;
DOI=10.1128/JB.184.19.5479-5490.2002; PubMed=12218036 [NCBI, ExPASy, EBI, Israel, Japan]
Fleischmann R.D.,
Alland D.,
Eisen J.A.,
Carpenter L.,
White O.,
Peterson J.D.,
DeBoy R.T.,
Dodson R.J.,
Gwinn M.L.,
Haft D.H.,
Hickey E.K.,
Kolonay J.F.,
Nelson W.C.,
Umayam L.A.,
Ermolaeva M.D.,
Salzberg S.L.,
Delcher A.,
Utterback T.R.,
Weidman J.F., ![]()
Khouri H.M.,
Gill J.,
Mikula A.,
Bishai W.,
Jacobs W.R. Jr.,
Venter J.C.,
Fraser C.M.;
"Whole-genome comparison of Mycobacterium tuberculosis clinical and laboratory strains.";
J. Bacteriol. 184:5479-5490(2002).
|
|
|
|
- FUNCTION: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity).
- CATALYTIC ACTIVITY: Pyruvate + [dihydrolipoyllysine-residue acetyltransferase] lipoyllysine = [dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + CO2.
- COFACTOR: Thiamine pyrophosphate (By similarity).
- SUBUNIT: Homodimer (By similarity).
|
|
|
|
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms.
Distributed under the Creative Commons Attribution-NoDerivs License.
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| Length: 901 AA [This is the length of the unprocessed precursor] |
Molecular weight: 100217 Da [This is the MW of the unprocessed precursor] |
CRC64: F7910AA5722539BF [This is a checksum on the sequence] |
|
10 20 30 40 50 60
MASYLPDIDP EETSEWLESF DTLLQRCGPS RARYLMLRLL ERAGEQRVAI PALTSTDYVN
70 80 90 100 110 120
TIPTELEPWF PGDEDVERRY RAWIRWNAAI MVHRAQRPGV GVGGHISTYA SSAALYEVGF
130 140 150 160 170 180
NHFFRGKSHP GGGDQVFIQG HASPGIYARA FLEGRLTAEQ LDGFRQEHSH VGGGLPSYPH
190 200 210 220 230 240
PRLMPDFWEF PTVSMGLGPL NAIYQARFNH YLHDRGIKDT SDQHVWCFLG DGEMDEPESR
250 260 270 280 290 300
GLAHVGALEG LDNLTFVINC NLQRLDGPVR GNGKIIQELE SFFRGAGWNV IKVVWGREWD
310 320 330 340 350 360
ALLHADRDGA LVNLMNTTPD GDYQTYKAND GGYVRDHFFG RDPRTKALVE NMSDQDIWNL
370 380 390 400 410 420
KRGGHDYRKV YAAYRAAVDH KGQPTVILAK TIKGYALGKH FEGRNATHQM KKLTLEDLKE
430 440 450 460 470 480
FRDTQRIPVS DAQLEENPYL PPYYHPGLNA PEIRYMLDRR RALGGFVPER RTKSKALTLP
490 500 510 520 530 540
GRDIYAPLKK GSGHQEVATT MATVRTFKEV LRDKQIGPRI VPIIPDEART FGMDSWFPSL
550 560 570 580 590 600
KIYNRNGQLY TAVDADLMLA YKESEVGQIL HEGINEAGSV GSFIAAGTSY ATHNEPMIPI
610 620 630 640 650 660
YIFYSMFGFQ RTGDSFWAAA DQMARGFVLG ATAGRTTLTG EGLQHADGHS LLLAATNPAV
670 680 690 700 710 720
VAYDPAFAYE IAYIVESGLA RMCGENPENI FFYITVYNEP YVQPPEPENF DPEGVLRGIY
730 740 750 760 770 780
RYHAATEQRT NKAQILASGV AMPAALRAAQ MLAAEWDVAA DVWSVTSWGE LNRDGVAIET
790 800 810 820 830 840
EKLRHPDRPA GVPYVTRALE NARGPVIAVS DWMRAVPEQI RPWVPGTYLT LGTDGFGFSD
850 860 870 880 890 900
TRPAARRYFN TDAESQVVAV LEALAGDGEI DPSVPVAAAR QYRIDDVAAA PEQTTDPGPG
A
|
Q10504 in FASTA format |
|
ExPASy Home page
SIB Switzerland