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[1]
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NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=ATCC 38366 / 972;
DOI=10.1093/nar/gkl421; PubMed=16877568 [NCBI, ExPASy, EBI, Israel, Japan]
Proshkina G.M.,
Shematorova E.K.,
Proshkin S.A.,
Zaros C.,
Thuriaux P.,
Shpakovski G.V.;
"Ancient origin, functional conservation and fast evolution of DNA-dependent RNA polymerase III.";
Nucleic Acids Res. 34:3615-3624(2006).
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[2]
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NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 38366 / 972;
DOI=10.1038/nature724; PubMed=11859360 [NCBI, ExPASy, EBI, Israel, Japan]
Wood V.,
Gwilliam R.,
Rajandream M.A.,
Lyne M.H.,
Lyne R.,
Stewart A.,
Sgouros J.G.,
Peat N.,
Hayles J.,
Baker S.G.,
Basham D.,
Bowman S.,
Brooks K.,
Brown D.,
Brown S.,
Chillingworth T.,
Churcher C.M.,
Collins M.,
Connor R., ![]()
Cronin A.,
Davis P.,
Feltwell T.,
Fraser A.,
Gentles S.,
Goble A.,
Hamlin N.,
Harris D.E.,
Hidalgo J.,
Hodgson G.,
Holroyd S.,
Hornsby T.,
Howarth S.,
Huckle E.J.,
Hunt S.,
Jagels K.,
James K.D.,
Jones L.,
Jones M.,
Leather S.,
McDonald S.,
McLean J.,
Mooney P.,
Moule S.,
Mungall K.L.,
Murphy L.D.,
Niblett D.,
Odell C.,
Oliver K.,
O'Neil S.,
Pearson D.,
Quail M.A.,
Rabbinowitsch E.,
Rutherford K.M.,
Rutter S.,
Saunders D.,
Seeger K.,
Sharp S.,
Skelton J.,
Simmonds M.N.,
Squares R.,
Squares S.,
Stevens K.,
Taylor K.,
Taylor R.G.,
Tivey A.,
Walsh S.V.,
Warren T.,
Whitehead S.,
Woodward J.R.,
Volckaert G.,
Aert R.,
Robben J.,
Grymonprez B.,
Weltjens I.,
Vanstreels E.,
Rieger M.,
Schaefer M.,
Mueller-Auer S.,
Gabel C.,
Fuchs M.,
Duesterhoeft A.,
Fritzc C.,
Holzer E.,
Moestl D.,
Hilbert H.,
Borzym K.,
Langer I.,
Beck A.,
Lehrach H.,
Reinhardt R.,
Pohl T.M.,
Eger P.,
Zimmermann W.,
Wedler H.,
Wambutt R.,
Purnelle B.,
Goffeau A.,
Cadieu E.,
Dreano S.,
Gloux S.,
Lelaure V.,
Mottier S.,
Galibert F.,
Aves S.J.,
Xiang Z.,
Hunt C.,
Moore K.,
Hurst S.M.,
Lucas M.,
Rochet M.,
Gaillardin C.,
Tallada V.A.,
Garzon A.,
Thode G.,
Daga R.R.,
Cruzado L.,
Jimenez J.,
Sanchez M.,
del Rey F.,
Benito J.,
Dominguez A.,
Revuelta J.L.,
Moreno S.,
Armstrong J.,
Forsburg S.L.,
Cerutti L.,
Lowe T.,
McCombie W.R.,
Paulsen I.,
Potashkin J.,
Shpakovski G.V.,
Ussery D.,
Barrell B.G.,
Nurse P.;
"The genome sequence of Schizosaccharomyces pombe.";
Nature 415:871-880(2002).
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- FUNCTION: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol III is composed of mobile elements and RPC2 is part of the core element with the central large cleft and probably a clamp element that moves to open and close the cleft (By similarity).
- CATALYTIC ACTIVITY: Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).
- SUBUNIT: Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits (By similarity).
- SUBCELLULAR LOCATION: Nucleus (By similarity).
- SIMILARITY: Belongs to the RNA polymerase beta chain family.
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Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms.
Distributed under the Creative Commons Attribution-NoDerivs License.
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| Length: 1165 AA [This is the length of the unprocessed precursor] |
Molecular weight: 130238 Da [This is the MW of the unprocessed precursor] |
CRC64: 6690055F257EC0EB [This is a checksum on the sequence] |
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10 20 30 40 50 60
MGVNTAGDPQ KSQPKINKGG IGKDESFGAL FKPVYKGKKL ADPVPTIEDK WQLLPAFLKV
70 80 90 100 110 120
KGLVKQHLDS YNYFVDVDLK KIVQANEKVT SDVEPWFYLK YLDIRVGAPV RTDADAIQAS
130 140 150 160 170 180
ISPHECRLRD LTYGANIYVD IEYTRGKQVV RRRNVPIGRM PVMLRSNKCV LSGKNEMEMA
190 200 210 220 230 240
ALNECPLDPG GYFIVKGTEK VILVQEQLSK NRIIVEAEPK KGLWQASVTS STHERKSKTY
250 260 270 280 290 300
VITKNGKLYL KHNSVADDIP IVVVLKAMGL QSDQEIFELV AGAEASYQDL FAPSIEECAK
310 320 330 340 350 360
LNIYTAQQAL EYIGARVKVN RRAGANRLPP HEEALEVLAA VVLAHINVFN LEFRPKAVYI
370 380 390 400 410 420
GIMARRVLMA MVDPLQVDDR DYVGNKRLEL AGQLLALLFE DLFKKFNSDL KLNIDKVLKK
430 440 450 460 470 480
PHRTQEFDAY NQLTVHSDHI TQGMVRALST GNWSLKRFKM ERAGVTHVLS RLSYISALGM
490 500 510 520 530 540
MTRITSQFEK TRKVSGPRSL QASQFGMLCT SDTPEGEACG LVKNLALMTH ITTDEEEEPI
550 560 570 580 590 600
IKLAYAFGIE DIHVISGREL HSHGTYLVYL NGAILGISRY PSLFVASFRK LRRSGKISPF
610 620 630 640 650 660
IGIFINTHQR AVFISTDGGR ICRPLIIVQN GLPKVESKHI RLLKEGKWGF EDFLKQGLVE
670 680 690 700 710 720
YVDVNEENDS LISVYERDIT PDTTHLEIEP FTILGAVAGL IPYPHHNQSP RNTYQCAMGK
730 740 750 760 770 780
QAIGAIAYNQ LQRIDTLLYL MVYPQQPMVK TKTIELIGYD KLPAGQNATV AIMSYSGYDI
790 800 810 820 830 840
EDALVLNKSS IDRGFGRCQV FHKHSVIVRK YPNGTHDRIG DPQRDPETGE VVWKHGVVED
850 860 870 880 890 900
DGLAGVGCRV QPGQIYVNKQ TPTNALDNSI TLGHTQTVES GYKATPMTYK APEPGYIDKV
910 920 930 940 950 960
MLTTTDSDQT LIKVLMRQTR RPELGDKFSS RHGQKGVCGV IVQQEDMPFN DQGICPDIIM
970 980 990 1000 1010 1020
NPHGFPSRMT VGKMIELLSG KVGVLRGTLE YGTCFGGTKV EDASRILVEH GYNYSGKDML
1030 1040 1050 1060 1070 1080
TSGITGETLE AYIFMGPIYY QKLKHMVMDK MHARARGPRA VLTRQPTEGR SRDGGLRLGE
1090 1100 1110 1120 1130 1140
MERDCLIAYG ASQLLLERLM ISSDACDVDV CGQCGLLGYK GWCNSCQSTR EVVKMTIPYA
1150 1160
AKLLFQELLS MNIVPRLALE DEFKY
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Q10233 in FASTA format |
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