[1]	NUCLEOTIDE SEQUENCE. STRAIN=CTS/Shi, and NOD/Shi; Inoue K., Ikegami H., Fujisawa T., Noso S., Babaya N., Ogihara T.; "Tnfa sequences."; Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.

Comments

Copyright

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Cross-references

Sequence databases

EMBL

AB185895; BAF02299.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
AB185896; BAF02300.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]

IPI

IPI00128861; -.

UniGene

Mm.1293

3D structure databases

SMR

Q0X0E6; 1-138.

ModBase

Q0X0E6.

Organism-specific databases

MGI

MGI:104798; Tnf.

Gene expression databases

ArrayExpress

Q0X0E6; -.

Bgee

Q0X0E6; -.

Ontologies

GO:0005615;	Cellular component: extracellular space (inferred from direct assay from MGI).
GO:0005887;	Cellular component: integral to plasma membrane (traceable author statement from MGI).
GO:0030141;	Cellular component: secretory granule (traceable author statement from MGI).
GO:0005125;	Molecular function: cytokine activity (inferred from direct assay from MGI).
GO:0042802;	Molecular function: identical protein binding (inferred from electronic annotation from Compara).
GO:0005164;	Molecular function: tumor necrosis factor receptor binding (inferred from direct assay from MGI).
GO:0005164;	Molecular function: tumor necrosis factor receptor binding (inferred from physical interaction from MGI).
GO:0005164;	Molecular function: tumor necrosis factor receptor binding (traceable author statement from MGI).
GO:0000187;	Biological process: activation of MAPK activity (inferred from electronic annotation from Compara).
GO:0006916;	Biological process: anti-apoptosis (inferred from electronic annotation from Compara).
GO:0019722;	Biological process: calcium-mediated signaling (inferred from electronic annotation from Compara).
GO:0006919;	Biological process: activation of caspase activity (inferred from electronic annotation from Compara).
GO:0001775;	Biological process: cell activation (inferred from electronic annotation from Compara).
GO:0002439;	Biological process: chronic inflammatory response to antigenic stimulus (inferred from electronic annotation from Compara).
GO:0042742;	Biological process: defense response to bacterium (inferred from direct assay from MGI).
GO:0006006;	Biological process: glucose metabolic process (inferred from direct assay from MGI).
GO:0006959;	Biological process: humoral immune response (inferred from mutant phenotype from MGI).
GO:0008625;	Biological process: induction of apoptosis via death domain receptors (inferred from genetic interaction from MGI).
GO:0050901;	Biological process: leukocyte tethering or rolling (inferred from electronic annotation from Compara).
GO:0008285;	Biological process: negative regulation of cell proliferation (inferred from electronic annotation from Compara).
GO:0002740;	Biological process: negative regulation of cytokine secretion during immune response (inferred from electronic annotation from Compara).
GO:0046325;	Biological process: negative regulation of glucose import (inferred from direct assay from MGI).
GO:0032715;	Biological process: negative regulation of interleukin-6 production (inferred from electronic annotation from Compara).
GO:0002037;	Biological process: negative regulation of L-glutamate transport (inferred from electronic annotation from Compara).
GO:0000122;	Biological process: negative regulation of transcription from RNA polymerase II promoter (inferred from direct assay from MGI).
GO:0045071;	Biological process: negative regulation of viral genome replication (inferred from electronic annotation from Compara).
GO:0009887;	Biological process: organ morphogenesis (inferred from mutant phenotype from MGI).
GO:0045080;	Biological process: positive regulation of chemokine biosynthetic process (inferred from electronic annotation from Compara).
GO:0032722;	Biological process: positive regulation of chemokine production (inferred from electronic annotation from Compara).
GO:0050715;	Biological process: positive regulation of cytokine secretion (inferred from electronic annotation from Compara).
GO:0043193;	Biological process: positive regulation of gene-specific transcription (inferred from electronic annotation from Compara).
GO:0034116;	Biological process: positive regulation of heterotypic cell-cell adhesion (inferred from electronic annotation from Compara).
GO:0043123;	Biological process: positive regulation of I-kappaB kinase/NF-kappaB cascade (inferred from direct assay from MGI).
GO:0046330;	Biological process: positive regulation of JNK cascade (inferred from direct assay from MGI).
GO:0045840;	Biological process: positive regulation of mitosis (inferred from electronic annotation from Compara).
GO:0043525;	Biological process: positive regulation of neuron apoptosis (inferred from electronic annotation from Compara).
GO:0042346;	Biological process: positive regulation of NF-kappaB import into nucleus (inferred from electronic annotation from Compara).
GO:0051092;	Biological process: positive regulation of NF-kappaB transcription factor activity (inferred from electronic annotation from Compara).
GO:0045429;	Biological process: positive regulation of nitric oxide biosynthetic process (inferred from electronic annotation from Compara).
GO:0001934;	Biological process: positive regulation of protein amino acid phosphorylation (inferred from electronic annotation from Compara).
GO:0048661;	Biological process: positive regulation of smooth muscle cell proliferation (inferred from electronic annotation from Compara).
GO:0050806;	Biological process: positive regulation of synaptic transmission (inferred from electronic annotation from Compara).
GO:0045944;	Biological process: positive regulation of transcription from RNA polymerase II promoter (inferred from direct assay from MGI).
GO:0045994;	Biological process: positive regulation of translational initiation by iron (inferred from direct assay from MGI).
GO:0000060;	Biological process: protein import into nucleus, translocation (inferred from electronic annotation from Compara).
GO:0032800;	Biological process: receptor biosynthetic process (inferred from electronic annotation from Compara).
GO:0051023;	Biological process: regulation of immunoglobulin secretion (inferred from direct assay from MGI).
GO:0050796;	Biological process: regulation of insulin secretion (inferred from electronic annotation from Compara).
GO:0045670;	Biological process: regulation of osteoclast differentiation (inferred from direct assay from MGI).
GO:0051384;	Biological process: response to glucocorticoid stimulus (inferred from electronic annotation from Compara).
GO:0009612;	Biological process: response to mechanical stimulus (inferred from electronic annotation from Compara).
GO:0009615;	Biological process: response to virus (inferred from electronic annotation from Compara).
GO:0006927;	Biological process: transformed cell apoptosis (traceable author statement from MGI).
GO:0033209;	Biological process: tumor necrosis factor-mediated signaling pathway (inferred from electronic annotation from Compara).
QuickGo view.

Family and domain databases

InterPro

IPR006053; TNF_abc.
IPR002959; TNF_alpha.
IPR006052; TNF_family.
IPR008983; Tumour_necrosis_fac-like.
Graphical view of domain structure.

Gene3D

G3DSA:2.60.120.40; Tumour_necrosis_fac-like; 1.

Pfam

PF00229; TNF; 1.
Pfam graphical view of domain structure.

PRINTS

PR01234; TNECROSISFCT.
PR01235; TNFALPHA.

ProDom

PD002012; TNF_subf; 1.
[Domain structure / List of seq. sharing at least 1 domain]

SMART

SM00207; TNF; 1.
SMART graphical view of domain structure.

PROSITE

PS00251; TNF_1; 1.
PS50049; TNF_2; 1.
PROSITE graphical view of domain structure (profiles).

Genome annotation databases

Ensembl

ENSMUSG00000024401; Mus musculus. [Contig view]

Phylogenomic databases

HOVERGEN

Q0X0E6; -.

Other

SOURCE

Tnf; Mus musculus.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Cytokine; Membrane.

Features

Feature table viewer

`Key`	`From To`	`Length`		`Description`
`NON_TER`	`1 1`

Sequence information

Length: 138 AA [This is the length of the partial sequence]

Molecular weight: 15394 Da [This is the MW of the partial sequence]

CRC64: 14FB32C50CA144BD [This is a checksum on the sequence]

        10         20         30         40         50         60 
NHQVEEQLEW LSQRANALLA NGMDLKDNQL VVPADGLYLV YSQVLFKGQG CPDYVLLTHT 

        70         80         90        100        110        120 
VSRFAISYQE KVNLLSAVKS PCPKDTPEGA ELKPWYEPIY LGGVFQLEKG DQLSAEVNLP 

       130 
KYLDFAESGQ VYFGVIAL

Q0X0E6 in FASTA format

View entry in raw text format (no links)
Request for annotation of this UniProtKB/TrEMBL entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools