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UniProtKB/Swiss-Prot entry Q0VSY7


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name GSH1_ALCBS
Primary accession number Q0VSY7
Secondary accession numbers None
Integrated into Swiss-Prot on January 15, 2008
Sequence was last modified on September 5, 2006 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 17)
Name and origin of the protein
Protein name Glutamate--cysteine ligase
Synonyms EC 6.3.2.2
Gamma-glutamylcysteine synthetase
Gamma-ECS
GCS
Gene name
Name: gshA
OrderedLocusNames: ABO_0263
From
Alcanivorax borkumensis (strain SK2 / ATCC 700651 / DSM 11573) [TaxID: 393595] [HAMAP proteome]
Taxonomy Bacteria; Proteobacteria; Gammaproteobacteria; Oceanospirillales; Alcanivoracaceae; Alcanivorax.
Protein existence 3: Inferred from homology;
References
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1038/nbt1232; PubMed=16878126 [NCBI, ExPASy, EBI, Israel, Japan]
Schneiker S., Martins dos Santos V.A.P., Bartels D., Bekel T., Brecht M., Buhrmester J., Chernikova T.N., Denaro R., Ferrer M., Gertler C., Goesmann A., Golyshina O.V., Kaminski F., Khachane A.N., Lang S., Linke B., McHardy A.C., Meyer F., Nechitaylo T., Puehler A., Regenhardt D., Rupp O., Sabirova J.S., Selbitschka W., Yakimov M.M., Timmis K.N., Vorhoelter F.-J., Weidner S., Kaiser O., Golyshin P.N.;
"Genome sequence of the ubiquitous hydrocarbon-degrading marine bacterium Alcanivorax borkumensis.";
Nat. Biotechnol. 24:997-1004(2006).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AM286690; CAL15711.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq YP_691983.1; -.
3D structure databases
ModBase Q0VSY7.
Enzyme and pathway databases
BioCyc ABOR393595:ABO_0263-MON; -.
Ontologies
GO
GO:0004357; Molecular function: glutamate-cysteine ligase activity (inferred from electronic annotation from HAMAP).
GO:0006750; Biological process: glutathione biosynthetic process (inferred from electronic annotation from HAMAP).
QuickGo view.
Family and domain databases
HAMAP MF_00578; -; 1.
PBIL [Tree]
InterPro IPR007370; Glu_cys_ligase.
IPR006334; Glut_cys_ligase.
Graphical view of domain structure.
Pfam PF04262; Glu_cys_ligase; 1.
Pfam graphical view of domain structure.
TIGRFAMs TIGR01434; glu_cys_ligase; 1.
ProtoNet Q0VSY7.
Genome annotation databases
GeneID 4212782; -.
GenomeReviews AM286690_GR; ABO_0263.
KEGG abo:ABO_0263; -.
NMPDR fig|393595.12.peg.260; -.
Phylogenomic databases
HOGENOM Q0VSY7; -.
Genome annotation databases
CMR Q0VSY7; ABO_0263.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; Glutathione biosynthesis; Ligase.
Features
SEVIEWER logo Feature table viewer
KeyFrom To Length Description FTId
CHAIN   1   525  525     Glutamate--cysteine ligase. PRO_1000025167
Sequence information
Length: 525 AA [This is the length of the unprocessed precursor] Molecular weight: 59733 Da [This is the MW of the unprocessed precursor] CRC64: 0C5DF416630C2313 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MKHLEQRIHA LLNADAAATL AGIRRGIEKE SLRITTDGTL AQTPHPRALG SALTHPYITT 

        70         80         90        100        110        120 
DYSEALLEFI TPPSTELHKP IEFLEQLHRY VYSHIGDEVL WVNSMPCMIG KDSDVPVAQY 

       130        140        150        160        170        180 
GSSNVGRMKT VYREGLGHRY GRKMQTIAGI HYNFSYPDAF WKLNQQLEGD NAPLQDYISR 

       190        200        210        220        230        240 
RYFDLTRNFQ RYSWLLVYLF GASPALCASF LAGREHDLLE RFDHSLYRPQ ATSLRMSDLG 

       250        260        270        280        290        300 
YQNNAQSSLA ISYNNLDEYV STLTHAINTP EPAYEKMGVK VTDADGNVKY QQLNANILQI 

       310        320        330        340        350        360 
ENEYYSSIRP KRTIKPGERP TTALQERGVE YIEIRALDLN PFEPVGINQQ EIRFLDLFAT 

       370        380        390        400        410        420 
YCLLRESPQL EKCDLHASKE NLRKVVYDGR NTDIQLYNWG KSVSLKNWAS EKLTQMQPIA 

       430        440        450        460        470        480 
ELFDRAHGGN NYAEALAHQQ EKVDNPSATP SAQILEQLES RNQGFFQFAM EQALAHRDHF 

       490        500        510        520 
LSGQRCDATN QQLEALAADS LAEQAAGEAA DQQSFEEYLA DYFHD 

Q0VSY7 in FASTA format

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