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UniProtKB/Swiss-Prot entry Q0VQ52

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name MDH_ALCBS
Primary accession number Q0VQ52
Secondary accession numbers None
Integrated into Swiss-Prot on July 10, 2007
Sequence was last modified on September 5, 2006 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 20)
Name and origin of the protein
Protein name Malate dehydrogenase
Synonym EC 1.1.1.37
Gene name
Name: mdh
OrderedLocusNames: ABO_1248
From
Alcanivorax borkumensis (strain SK2 / ATCC 700651 / DSM 11573) [TaxID: 393595] [HAMAP proteome]
Taxonomy Bacteria; Proteobacteria; Gammaproteobacteria; Oceanospirillales; Alcanivoracaceae; Alcanivorax.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1038/nbt1232; PubMed=16878126 [NCBI, ExPASy, EBI, Israel, Japan]
Schneiker S., Martins dos Santos V.A.P., Bartels D., Bekel T., Brecht M., Buhrmester J., Chernikova T.N., Denaro R., Ferrer M., Gertler C., Goesmann A., Golyshina O.V., Kaminski F., Khachane A.N., Lang S., Linke B., McHardy A.C., Meyer F., Nechitaylo T., Puehler A., Regenhardt D., Rupp O., Sabirova J.S., Selbitschka W., Yakimov M.M., Timmis K.N., Vorhoelter F.-J., Weidner S., Kaiser O., Golyshin P.N.;
"Genome sequence of the ubiquitous hydrocarbon-degrading marine bacterium Alcanivorax borkumensis.";
Nat. Biotechnol. 24:997-1004(2006).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AM286690; CAL16696.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq YP_692968.1; -.
3D structure databases
ModBase Q0VQ52.
Enzyme and pathway databases
BioCyc ABOR393595:ABO_1248-MON; -.
Ontologies
GO
GO:0030060; Molecular function: L-malate dehydrogenase activity (inferred from electronic annotation from HAMAP).
GO:0006099; Biological process: tricarboxylic acid cycle (inferred from electronic annotation from HAMAP).
QuickGo view.
Family and domain databases
HAMAP MF_01517; -; 1.
PBIL [Tree]
InterPro IPR001557; L-lactate/malate_DHase.
IPR001236; Lactate/malate_DHase.
IPR015955; Lactate_DHase/Glyco_Ohase_4_C.
IPR001252; Malate_DHase_AS.
IPR010945; Malate_DHase_SF1.
IPR016040; NAD(P)-bd.
Graphical view of domain structure.
Gene3D G3DSA:3.90.110.10; lact_mal_DH; 1.
G3DSA:3.40.50.720; NAD(P)-bd; 1.
PANTHER PTHR23382; MDH_SF1; 1.
Pfam PF02866; Ldh_1_C; 1.
PF00056; Ldh_1_N; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF000102; Lac_mal_DH; 1.
ProDom PD003052; Mal_dehydrog; 1.
[Domain structure / List of seq. sharing at least 1 domain]
TIGRFAMs TIGR01759; MalateDH-SF1; 1.
PROSITE PS00068; MDH; 1.
BLOCKS Q0VQ52.
Genome annotation databases
GeneID 4211498; -.
GenomeReviews AM286690_GR; ABO_1248.
KEGG abo:ABO_1248; -.
NMPDR fig|393595.12.peg.1259; -.
Phylogenomic databases
HOGENOM Q0VQ52; -.
Genome annotation databases
CMR Q0VQ52; ABO_1248.
Other
ProtoNet Q0VQ52.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; NAD; Oxidoreductase; Tricarboxylic acid cycle.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   328  328     Malate dehydrogenase. PRO_0000294372
NP_BIND   13    19  7     NAD (By similarity). 
NP_BIND   131   133  3     NAD (By similarity). 
ACT_SITE   189   189        Proton acceptor (By similarity). 
BINDING   94    94        Substrate (By similarity). 
BINDING   100   100        Substrate (By similarity). 
BINDING   107   107        NAD (By similarity). 
BINDING   114   114        NAD (By similarity). 
BINDING   133   133        Substrate (By similarity). 
BINDING   164   164        Substrate (By similarity). 
Sequence information
Length: 328 AA [This is the length of the unprocessed precursor] Molecular weight: 35407 Da [This is the MW of the unprocessed precursor] CRC64: B9EB0E5352E4CBBA [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MFMKAPVRVA VTGAAGQISY SLLFRIASGD MLGKDQPVIL QLLEITPALE ALNGVIMELE 

        70         80         90        100        110        120 
DCAFPLVAGI TGTDDANVAF KDADYALLVG ARPRGPGMER KDLLEANAAI FSAQGKAIND 

       130        140        150        160        170        180 
NASKGIKVLV VGNPANTNAL IAQRNAPDID PRQFTAMTRL DHNRAMAQLA NKLGKTVNDV 

       190        200        210        220        230        240 
KKMLIWGNHS STQYPDLHHC EVDGKVAIDQ VEQDWYENDY IPTVQQRGAA IIKARGASSA 

       250        260        270        280        290        300 
ASAANAAVDH MRSWALGTDE GDWVSMGIYS DGSYGIQEGL IYSFPCTCKN GDWTIVQGLE 

       310        320 
VNDFSRGKMQ ATEQELAEER DAVSHLLP
Q0VQ52 in FASTA format

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