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UniProtKB/TrEMBL entry Q0PMN1

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name Q0PMN1_MOUSE
Primary accession number Q0PMN1
Secondary accession numbers None
Integrated into TrEMBL on September 5, 2006
Sequence was last modified on September 5, 2006 (Sequence version 1)
Annotations were last modified on    March 3, 2009 (Entry version 20)
Name and origin of the protein
Protein name Interleukin-6
Synonyms None
Gene name
Name: Il6
From
Mus musculus (Mouse) [TaxID: 10090] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus.
Protein existence 2: Evidence at transcript level;
References
[1]
 NUCLEOTIDE SEQUENCE.
STRAIN=BALB/c;
Liu Y.-L., Fan Y.-H., Chiou S.-H.;
Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases.
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
DQ788722; ABG81953.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
IPI IPI00133702; -.
UniGene Mm.1019
3D structure databases
ModBase Q0PMN1.
Organism-specific databases
MGI MGI:96559; Il6.
Gene expression databases
ArrayExpress Q0PMN1; -.
Bgee Q0PMN1; -.
Ontologies
GO
GO:0009897; Cellular component: external side of plasma membrane (inferred from direct assay from MGI).
GO:0005615; Cellular component: extracellular space (inferred from direct assay from MGI).
GO:0005125; Molecular function: cytokine activity (inferred from direct assay from MGI).
GO:0005138; Molecular function: interleukin-6 receptor binding (inferred from electronic annotation from InterPro).
GO:0042832; Biological process: defense response to protozoan (inferred from mutant phenotype from MGI).
GO:0046716; Biological process: muscle maintenance (inferred from genetic interaction from MGI).
GO:0045079; Biological process: negative regulation of chemokine biosynthetic process (inferred from direct assay from MGI).
GO:0046888; Biological process: negative regulation of hormone secretion (inferred from direct assay from MGI).
GO:0001781; Biological process: neutrophil apoptosis (inferred from direct assay from MGI).
GO:0050679; Biological process: positive regulation of epithelial cell proliferation (inferred from direct assay from MGI).
GO:0045630; Biological process: positive regulation of T-helper 2 cell differentiation (inferred from direct assay from MGI).
GO:0045893; Biological process: positive regulation of transcription, DNA-dependent (inferred from direct assay from MGI).
GO:0007435; Biological process: salivary gland morphogenesis (inferred from direct assay from MGI).
QuickGo view.
Family and domain databases
InterPro IPR012351; 4_helix_cytokine_core.
IPR003573; IL6_MGF_GCSF.
IPR003574; Interleukin_6.
Graphical view of domain structure.
Gene3D G3DSA:1.20.1250.10; 4_helix_cytokine_core; 1.
PANTHER PTHR11457; Interleukin_6; 1.
Pfam PF00489; IL6; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF001935; IL6_MGF_GCSF; 1.
PRINTS PR00433; IL6GCSFMGF.
PR00434; INTERLEUKIN6.
SMART SM00126; IL6; 1.
SMART graphical view of domain structure.
PROSITE PS00254; INTERLEUKIN_6; 1.
Genome annotation databases
Ensembl ENSMUSG00000025746; Mus musculus. [Contig view]
Phylogenomic databases
HOVERGEN Q0PMN1; -.
Other
SOURCE Il6; Mus musculus.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
None
Features
None
Sequence information
Length: 211 AA Molecular weight: 24368 Da CRC64: BBB466B69E86787A [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MKFLSARDFH PVAFLGLMLV TTTAFPTSQV RRGDFTEDTT PNRPVYTTSQ VGGLITHVLW 

        70         80         90        100        110        120 
EIVEMRKELC NGNSDCMNND DALAENNLKL PEIQRNDGCY QTGYNQEICL LKISSGLLEY 

       130        140        150        160        170        180 
HSYLEYMKNN LKDNKKDKAR VLQRDTETLI HIFNQEVKDL HKIVLPTPIS NALLTDKLES 

       190        200        210 
QKEWLRTKTI QFILKSLEEF PKVTLRSTRQ T
Q0PMN1 in FASTA format

View entry in raw text format (no links)
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