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UniProtKB/Swiss-Prot entry Q09152


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name FPPS1_ARATH
Primary accession number Q09152
Secondary accession numbers Q42573 Q8W504 Q93Y84
Integrated into Swiss-Prot on November 1, 1995
Sequence was last modified on June 6, 2002 (Sequence version 2)
Annotations were last modified on    September 2, 2008 (Entry version 72)
Name and origin of the protein
Protein name Farnesyl pyrophosphate synthetase 1, mitochondrial [Precursor]
Synonyms FPP synthetase 1
FPS 1
Farnesyl diphosphate synthetase 1
Includes Dimethylallyltranstransferase
     (EC 2.5.1.1)
Geranyltranstransferase
     (EC 2.5.1.10)
Gene name
Name: FPS1
OrderedLocusNames: At5g47770
ORFNames: MCA23.9
From
Arabidopsis thaliana (Mouse-ear cress) [TaxID: 3702] 
Taxonomy Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliophyta; eudicotyledons; core eudicotyledons; rosids; eurosids II; Brassicales; Brassicaceae; Arabidopsis.
Protein existence 2: Evidence at transcript level;
References
[1]
NUCLEOTIDE SEQUENCE [MRNA], AND ALTERNATIVE INITIATION.
STRAIN=cv. Columbia;
DOI=10.1074/jbc.272.24.15381; PubMed=9182568 [NCBI, ExPASy, EBI, Israel, Japan]
Cunillera N., Boronat A., Ferrer A.;
"The Arabidopsis thaliana FPS1 gene generates a novel mRNA that encodes a mitochondrial farnesyl-diphosphate synthase isoform.";
J. Biol. Chem. 272:15381-15388(1997).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=cv. Columbia;
DOI=10.1093/dnares/5.6.379; PubMed=10048488 [NCBI, ExPASy, EBI, Israel, Japan]
Asamizu E., Sato S., Kaneko T., Nakamura Y., Kotani H., Miyajima N., Tabata S.;
"Structural analysis of Arabidopsis thaliana chromosome 5. VIII. Sequence features of the regions of 1,081,958 bp covered by seventeen physically assigned P1 and TAC clones.";
DNA Res. 5:379-391(1998).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=cv. Columbia;
DOI=10.1126/science.1088305; PubMed=14593172 [NCBI, ExPASy, EBI, Israel, Japan]
Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.;
"Empirical analysis of transcriptional activity in the Arabidopsis genome.";
Science 302:842-846(2003).
[4]
NUCLEOTIDE SEQUENCE [MRNA] OF 42-384.
STRAIN=cv. Landsberg erecta;
DOI=10.1007/BF00019499; PubMed=7858223 [NCBI, ExPASy, EBI, Israel, Japan]
Delourme D., Lacroute F., Karst F.;
"Cloning of an Arabidopsis thaliana cDNA coding for farnesyl diphosphate synthase by functional complementation in yeast.";
Plant Mol. Biol. 26:1867-1873(1994).
[5]
NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] OF 42-384.
STRAIN=cv. Columbia;
DOI=10.1074/jbc.271.13.7774; PubMed=8631820 [NCBI, ExPASy, EBI, Israel, Japan]
Cunillera N., Arro M., Delourme D., Karst F., Boronat A., Ferrer A.;
"Arabidopsis thaliana contains two differentially expressed farnesyl-diphosphate synthase genes.";
J. Biol. Chem. 271:7774-7780(1996).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
U80605; AAB49290.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
L46367; AAF44787.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
L46367; AAB07264.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AB016886; BAB11324.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF370324; AAK44139.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AY063112; AAL34286.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
X75789; CAA53433.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR S52009; S52009.
RefSeq NP_199588.1; -.
UniGene At.21206
3D structure databases
HSSP P08836; 1UBY. [HSSP ENTRY / PDB]
ModBase Q09152.
Enzyme and pathway databases
BioCyc MetaCyc:AT5G47770-MON; -.
Organism-specific databases
TAIR At5g47770; -.
Gene expression databases
ArrayExpress Q09152; -.
GermOnline AT5G47770; Arabidopsis thaliana.
Family and domain databases
InterPro IPR000092; Polyprenyl_synt.
IPR008949; Terpenoid_synth.
Graphical view of domain structure.
Gene3D G3DSA:1.10.600.10; Terpenoid_synth; 1.
Pfam PF00348; polyprenyl_synt; 1.
Pfam graphical view of domain structure.
PROSITE PS00723; POLYPRENYL_SYNTHET_1; 1.
PS00444; POLYPRENYL_SYNTHET_2; 1.
BLOCKS Q09152.
Genome annotation databases
GeneID 834828; -.
GenomeReviews BA000015_GR; AT5G47770.
KEGG ath:AT5G47770; -.
NMPDR fig|3702.1.peg.26592; -.
Other
ProtoNet Q09152.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Alternative initiation; Cholesterol biosynthesis; Complete proteome; Cytoplasm; Isoprene biosynthesis; Lipid synthesis; Mitochondrion; Steroid biosynthesis; Sterol biosynthesis; Transferase; Transit peptide.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
TRANSIT   1     ?        Mitochondrion (Potential). 
CHAIN   ?   384        Farnesyl pyrophosphate synthetase 1, mitochondrial. PRO_0000016469
VAR_SEQ   1    41        Missing (in isoform Cytoplasmic). VSP_018808
CONFLICT   218   218        A -> S (in Ref. 4; CAA53433). 
CONFLICT   231   231        Y -> H (in Ref. 4; CAA53433). 
CONFLICT   324   324        P -> T (in Ref. 4; CAA53433). 
Sequence information
Length: 384 AA [This is the length of the unprocessed precursor] Molecular weight: 44261 Da [This is the MW of the unprocessed precursor] CRC64: E6808489D07D4F29 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MSVSCCCRNL GKTIKKAIPS HHLHLRSLGG SLYRRRIQSS SMETDLKSTF LNVYSVLKSD 

        70         80         90        100        110        120 
LLHDPSFEFT NESRLWVDRM LDYNVRGGKL NRGLSVVDSF KLLKQGNDLT EQEVFLSCAL 

       130        140        150        160        170        180 
GWCIEWLQAY FLVLDDIMDN SVTRRGQPCW FRVPQVGMVA INDGILLRNH IHRILKKHFR 

       190        200        210        220        230        240 
DKPYYVDLVD LFNEVELQTA CGQMIDLITT FEGEKDLAKY SLSIHRRIVQ YKTAYYSFYL 

       250        260        270        280        290        300 
PVACALLMAG ENLENHIDVK NVLVDMGIYF QVQDDYLDCF ADPETLGKIG TDIEDFKCSW 

       310        320        330        340        350        360 
LVVKALERCS EEQTKILYEN YGKPDPSNVA KVKDLYKELD LEGVFMEYES KSYEKLTGAI 

       370        380 
EGHQSKAIQA VLKSFLAKIY KRQK 

Q09152 in FASTA format

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