[1]
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NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
PubMed=8413254 [NCBI, ExPASy, EBI, Israel, Japan]
Bolger G.,
Michaeli T.,
Martins T.,
St John T.,
Steiner B.,
Rodgers L.,
Riggs M.,
Wigler M.,
Ferguson K.;
"A family of human phosphodiesterases homologous to the dunce learning and memory gene product of Drosophila melanogaster are potential targets for antidepressant drugs.";
Mol. Cell. Biol. 13:6558-6571(1993).
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[2]
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NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 4 AND 5).
DOI=10.1016/0014-5793(96)00300-6; PubMed=8797812 [NCBI, ExPASy, EBI, Israel, Japan]
Nemoz G.,
Zhang R.B.,
Sette C.,
Conti M.;
"Identification of cyclic AMP-phosphodiesterase variants from the PDE4D gene expressed in human peripheral mononuclear cells.";
FEBS Lett. 384:97-102(1996).
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[3]
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NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
TISSUE=Heart;
DOI=10.1016/0378-1119(94)90818-4; PubMed=8125310 [NCBI, ExPASy, EBI, Israel, Japan]
Baecker P.A.,
Obernolte R.,
Bach C.,
Yee C.,
Shelton E.R.;
"Isolation of a cDNA encoding a human rolipram-sensitive cyclic AMP phosphodiesterase (PDE IVD).";
Gene 138:253-256(1994).
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[4]
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NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 3; 4; 5 AND 6), AND SEQUENCE REVISION (ISOFORM 1).
PubMed=9371713 [NCBI, ExPASy, EBI, Israel, Japan]
Bolger G.B.,
Erdogan S.,
Jones R.E.,
Loughney K.,
Scotland G.,
Hoffmann R.,
Wilkinson I.,
Farrell C.,
Houslay M.D.;
"Characterization of five different proteins produced by alternatively spliced mRNAs from the human cAMP-specific phosphodiesterase PDE4D gene.";
Biochem. J. 328:539-548(1997).
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[5]
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NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 7), AND ALTERNATIVE SPLICING.
TISSUE=Umbilical vein endothelial cell;
DOI=10.1006/bbrc.2000.3146; PubMed=10913353 [NCBI, ExPASy, EBI, Israel, Japan]
Miro X.,
Casacuberta J.M.,
Gutierrez-Lopez M.D.,
Landazuri M.O.,
Puigdomenech P.;
"Phosphodiesterases 4D and 7A splice variants in the response of HUVEC cells to TNF-alpha1.";
Biochem. Biophys. Res. Commun. 274:415-421(2000).
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[6]
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NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 8; 9; 10 AND 11), PHOSPHORYLATION, AND TISSUE SPECIFICITY.
DOI=10.1016/S0898-6568(03)00042-1; PubMed=12834813 [NCBI, ExPASy, EBI, Israel, Japan]
Wang D.,
Deng C.,
Bugaj-Gaweda B.,
Kwan M.,
Gunwaldsen C.,
Leonard C.,
Xin X.,
Hu Y.,
Unterbeck A.,
De Vivo M.;
"Cloning and characterization of novel PDE4D isoforms PDE4D6 and PDE4D7.";
Cell. Signal. 15:883-891(2003).
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[7]
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NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 10 AND 11), AND INVOLVEMENT IN SUSCEPTIBILITY TO STRK1.
DOI=10.1038/ng1245; PubMed=14517540 [NCBI, ExPASy, EBI, Israel, Japan]
Gretarsdottir S.,
Thorleifsson G.,
Reynisdottir S.T.,
Manolescu A.,
Jonsdottir S.,
Jonsdottir T.,
Gudmundsdottir T.,
Bjarnadottir S.M.,
Einarsson O.B.,
Gudjonsdottir H.M.,
Hawkins M.,
Gudmundsson G.,
Gudmundsdottir H.,
Andrason H.,
Gudmundsdottir A.S.,
Sigurdardottir M.,
Chou T.T.,
Nahmias J.,
Goss S., ![]()
Sveinbjoernsdottir S.,
Valdimarsson E.M.,
Jakobsson F.,
Agnarsson U.,
Gudnason V.,
Thorgeirsson G.,
Fingerle J.,
Gurney M.,
Gudbjartsson D.,
Frigge M.L.,
Kong A.,
Stefansson K.,
Gulcher J.R.;
"The gene encoding phosphodiesterase 4D confers risk of ischemic stroke.";
Nat. Genet. 35:131-138(2003).
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[8]
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ERRATUM.
Gretarsdottir S.,
Thorleifsson G.,
Reynisdottir S.T.,
Manolescu A.,
Jonsdottir S.,
Jonsdottir T.,
Gudmundsdottir T.,
Bjarnadottir S.M.,
Einarsson O.B.,
Gudjonsdottir H.M.,
Hawkins M.,
Gudmundsson G.,
Gudmundsdottir H.,
Andrason H.,
Gudmundsdottir A.S.,
Sigurdardottir M.,
Chou T.T.,
Nahmias J.,
Goss S., ![]()
Sveinbjoernsdottir S.,
Valdimarsson E.M.,
Jakobsson F.,
Agnarsson U.,
Gudnason V.,
Thorgeirsson G.,
Fingerle J.,
Gurney M.,
Gudbjartsson D.,
Frigge M.L.,
Kong A.,
Stefansson K.,
Gulcher J.R.;
Nat. Genet. 37:555-555(2005).
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[9]
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NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 12).
Kalnine N.,
Chen X.,
Rolfs A.,
Halleck A.,
Hines L.,
Eisenstein S.,
Koundinya M.,
Raphael J.,
Moreira D.,
Kelley T.,
LaBaer J.,
Lin Y.,
Phelan M.,
Farmer A.;
"Cloning of human full-length CDSs in BD Creator(TM) system donor vector.";
Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
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[10]
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NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 8 AND 12).
TISSUE=Brain, and Testis;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
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[11]
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INTERACTION WITH GNB2L1.
PubMed=12193273 [NCBI, ExPASy, EBI, Israel, Japan]
Bolger G.B.,
McCahill A.,
Yarwood S.J.,
Steele M.S.,
Warwicker J.,
Houslay M.D.;
"Delineation of RAID1, the RACK1 interaction domain located within the unique N-terminal region of the cAMP-specific phosphodiesterase, PDE4D5.";
BMC Biochem. 3:24-24(2002).
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[12]
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INTERACTION WITH ARRB2, AND SUBCELLULAR LOCATION.
DOI=10.1074/jbc.M303772200; PubMed=14500724 [NCBI, ExPASy, EBI, Israel, Japan]
Bolger G.B.,
McCahill A.,
Huston E.,
Cheung Y.F.,
McSorley T.,
Baillie G.S.,
Houslay M.D.;
"The unique amino-terminal region of the PDE4D5 cAMP phosphodiesterase isoform confers preferential interaction with beta-arrestins.";
J. Biol. Chem. 278:49230-49238(2003).
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[13]
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HOMODIMERIZATION OF LONG ISOFORMS, ENZYME REGULATION BY ROLIPRAM AND PHOSPHATIDIC ACID, AND PHOSPHORYLATION AT SER-53 (ISOFORM 2).
DOI=10.1074/jbc.M312687200; PubMed=15131123 [NCBI, ExPASy, EBI, Israel, Japan]
Richter W.,
Conti M.;
"The oligomerization state determines regulatory properties and inhibitor sensitivity of type 4 cAMP-specific phosphodiesterases.";
J. Biol. Chem. 279:30338-30348(2004).
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[14]
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PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-49; SER-51; SER-55 AND SER-59 (ISOFORMS 7/12), AND MASS SPECTROMETRY.
TISSUE=Epithelium;
DOI=10.1016/j.cell.2006.09.026; PubMed=17081983 [NCBI, ExPASy, EBI, Israel, Japan]
Olsen J.V.,
Blagoev B.,
Gnad F.,
Macek B.,
Kumar C.,
Mortensen P.,
Mann M.;
"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.";
Cell 127:635-648(2006).
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[15]
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PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-197 AND SER-202, AND MASS SPECTROMETRY.
TISSUE=Epithelium;
DOI=10.1038/nbt1240; PubMed=16964243 [NCBI, ExPASy, EBI, Israel, Japan]
Beausoleil S.A.,
Villen J.,
Gerber S.A.,
Rush J.,
Gygi S.P.;
"A probability-based approach for high-throughput protein phosphorylation analysis and site localization.";
Nat. Biotechnol. 24:1285-1292(2006).
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[16]
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POSSIBLE INVOLVEMENT IN SUSCEPTIBILITY TO STRK1.
DOI=10.1038/ng1006-1091; PubMed=17006457 [NCBI, ExPASy, EBI, Israel, Japan]
Rosand J.,
Bayley N.,
Rost N.,
de Bakker P.I.W.;
"Many hypotheses but no replication for the association between PDE4D and stroke.";
Nat. Genet. 38:1091-1092(2006).
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[17]
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PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-18 AND THR-25, AND MASS SPECTROMETRY.
TISSUE=Epithelium;
DOI=10.1021/pr070152u; PubMed=17924679 [NCBI, ExPASy, EBI, Israel, Japan]
Yu L.-R.,
Zhu Z.,
Chan K.C.,
Issaq H.J.,
Dimitrov D.S.,
Veenstra T.D.;
"Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra.";
J. Proteome Res. 6:4150-4162(2007).
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[18]
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PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-18 AND SER-20, AND MASS SPECTROMETRY.
TISSUE=Platelet;
DOI=10.1021/pr0704130; PubMed=18088087 [NCBI, ExPASy, EBI, Israel, Japan]
Zahedi R.P.,
Lewandrowski U.,
Wiesner J.,
Wortelkamp S.,
Moebius J.,
Schuetz C.,
Walter U.,
Gambaryan S.,
Sickmann A.;
"Phosphoproteome of resting human platelets.";
J. Proteome Res. 7:526-534(2008).
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[19]
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X-RAY CRYSTALLOGRAPHY (2.9 ANGSTROMS) OF 388-715 IN COMPLEX WITH THE INHIBITOR ZARDAVERINE AND DIVALENT METAL IONS, AND MUTAGENESIS OF ASP-527 AND ARG-563.
DOI=10.1016/S0014-5793(02)03396-3; PubMed=12387865 [NCBI, ExPASy, EBI, Israel, Japan]
Lee M.E.,
Markowitz J.,
Lee J.-O.,
Lee H.;
"Crystal structure of phosphodiesterase 4D and inhibitor complex.";
FEBS Lett. 530:53-58(2002).
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[20]
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X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF 381-739 IN COMPLEX WITH CAMP AND DIVALENT METAL IONS.
DOI=10.1021/bi034653e; PubMed=14609333 [NCBI, ExPASy, EBI, Israel, Japan]
Huai Q.,
Colicelli J.,
Ke H.;
"The crystal structure of AMP-bound PDE4 suggests a mechanism for phosphodiesterase catalysis.";
Biochemistry 42:13220-13226(2003).
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[21]
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X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 381-739 IN COMPLEX WITH INHIBITOR.
DOI=10.1016/S0969-2126(03)00123-0; PubMed=12842049 [NCBI, ExPASy, EBI, Israel, Japan]
Huai Q.,
Wang H.,
Sun Y.,
Kim H.Y.,
Liu Y.,
Ke H.;
"Three-dimensional structures of PDE4D in complex with roliprams and implication on inhibitor selectivity.";
Structure 11:865-873(2003).
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[22]
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X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS) OF 381-714 IN COMPLEX WITH METAL IONS AND INHIBITOR.
DOI=10.1074/jbc.M311556200; PubMed=14668322 [NCBI, ExPASy, EBI, Israel, Japan]
Huai Q.,
Liu Y.,
Francis S.H.,
Corbin J.D.,
Ke H.;
"Crystal structures of phosphodiesterases 4 and 5 in complex with inhibitor 3-isobutyl-1-methylxanthine suggest a conformation determinant of inhibitor selectivity.";
J. Biol. Chem. 279:13095-13101(2004).
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[23]
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X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 380-756 IN COMPLEX WITH AMP; METAL IONS AND THE INHIBITOR ROLIPRAM.
DOI=10.1016/j.jmb.2004.01.040; PubMed=15003452 [NCBI, ExPASy, EBI, Israel, Japan]
Xu R.X.,
Rocque W.J.,
Lambert M.H.,
Vanderwall D.E.,
Luther M.A.,
Nolte R.T.;
"Crystal structures of the catalytic domain of phosphodiesterase 4B complexed with AMP, 8-Br-AMP, and rolipram.";
J. Mol. Biol. 337:355-365(2004).
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