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UniProtKB/Swiss-Prot entry Q08189

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name TGM3_MOUSE
Primary accession number Q08189
Secondary accession numbers None
Integrated into Swiss-Prot on February 1, 1995
Sequence was last modified on February 1, 1995 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 69)
Name and origin of the protein
Protein name Protein-glutamine gamma-glutamyltransferase E [Precursor]
Synonyms TGase E
TGE
TG(E)
EC 2.3.2.13
Transglutaminase-3
Contains Protein-glutamine gamma-glutamyltransferase E 50 kDa non-catalytic chain
Protein-glutamine gamma-glutamyltransferase E 27 kDa catalytic chain
Gene name
Name: Tgm3
Synonyms: Tgase3
From
Mus musculus (Mouse) [TaxID: 10090] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus.
Protein existence 2: Evidence at transcript level;
References
[1]
 NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=BALB/c;
TISSUE=Epidermis;
PubMed=8099584 [NCBI, ExPASy, EBI, Israel, Japan]
Kim I.-G., Gorman J.J., Park S.-C., Chung S.-I., Steinert P.M.;
"The deduced sequence of the novel protransglutaminase E (TGase3) of human and mouse.";
J. Biol. Chem. 268:12682-12690(1993).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
L10385; AAA40421.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR B45991; B45991.
UniGene Mm.2961
3D structure databases
HSSP Q08188; 1L9M. [HSSP ENTRY / PDB]
SMR Q08189; 2-693.
ModBase Q08189.
Organism-specific databases
MGI MGI:98732; Tgm3.
Gene expression databases
ArrayExpress Q08189; -.
CleanEx MM_TGM3; -.
GermOnline ENSMUSG00000027401; Mus musculus.
Ontologies
GO
GO:0001533; Cellular component: cornified envelope (traceable author statement from UniProtKB).
GO:0005737; Cellular component: cytoplasm (inferred from sequence or structural similarity from UniProtKB).
GO:0031234; Cellular component: extrinsic to internal side of plasma membrane (inferred from sequence or structural similarity from UniProtKB).
GO:0005509; Molecular function: calcium ion binding (inferred from sequence or structural similarity from UniProtKB).
GO:0019003; Molecular function: GDP binding (inferred from sequence or structural similarity from UniProtKB).
GO:0005525; Molecular function: GTP binding (inferred from sequence or structural similarity from UniProtKB).
GO:0003924; Molecular function: GTPase activity (inferred from sequence or structural similarity from UniProtKB).
GO:0000287; Molecular function: magnesium ion binding (inferred from sequence or structural similarity from UniProtKB).
GO:0003810; Molecular function: protein-glutamine gamma-glutamyltransferase activity (inferred from sequence or structural similarity from UniProtKB).
GO:0043163; Biological process: cell envelope organization (inferred from sequence or structural similarity from UniProtKB).
GO:0035315; Biological process: hair cell differentiation (traceable author statement from UniProtKB).
GO:0030216; Biological process: keratinocyte differentiation (inferred from sequence or structural similarity from UniProtKB).
GO:0018149; Biological process: peptide cross-linking (traceable author statement from UniProtKB).
GO:0051262; Biological process: protein tetramerization (inferred from sequence or structural similarity from UniProtKB).
GO:0043588; Biological process: skin development (traceable author statement from UniProtKB).
QuickGo view.
Family and domain databases
InterPro IPR013783; Ig-like_fold.
IPR008958; Transglutaminase_C.
IPR013808; Transglutaminase_CS.
IPR001102; Transglutaminase_N.
IPR002931; Trnsglumase_like.
Graphical view of domain structure.
Gene3D G3DSA:2.60.40.10; Ig-like_fold; 3.
Pfam PF00927; Transglut_C; 2.
PF01841; Transglut_core; 1.
PF00868; Transglut_N; 1.
Pfam graphical view of domain structure.
SMART SM00460; TGc; 1.
SMART graphical view of domain structure.
PROSITE PS00547; TRANSGLUTAMINASES; 1.
BLOCKS Q08189.
Genome annotation databases
Ensembl ENSMUSG00000027401; Mus musculus. [Contig view]
Phylogenomic databases
HOGENOM Q08189; -.
HOVERGEN Q08189; -.
Other
SOURCE Tgm3; Mus musculus.
ProtoNet Q08189.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Acyltransferase; Calcium; Keratinization; Metal-binding; Transferase; Zymogen.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   470  470     Protein-glutamine gamma-glutamyltransferase E 50 kDa non-catalytic chain. PRO_0000033654
CHAIN   471   693  223     Protein-glutamine gamma-glutamyltransferase E 27 kDa catalytic chain. PRO_0000033655
ACT_SITE   273   273        By similarity. 
ACT_SITE   331   331        By similarity. 
ACT_SITE   354   354        By similarity. 
METAL   394   394        Calcium (By similarity). 
METAL   396   396        Calcium (By similarity). 
METAL   444   444        Calcium (By similarity). 
METAL   449   449        Calcium (By similarity). 
Sequence information
Length: 693 AA [This is the length of the unprocessed precursor] Molecular weight: 77324 Da [This is the MW of the unprocessed precursor] CRC64: 8B3F0601735D4E84 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MSALQIQNVN WQVPMNRRAH HTDKFSSQDS IVRRGQPWEI ILVCNRSLES GEDLNFIVST 

        70         80         90        100        110        120 
GPQPSESART KAVFSISGRS TGGWNAALKA NSGNNLAIAI ASPVSAPIGL YTLSVEISSR 

       130        140        150        160        170        180 
GRASSLKLGT FIMLFNPWLQ ADDVFMSNHA ERQEYVEEDS GIIYVGSTNR IGMVGWNFGQ 

       190        200        210        220        230        240 
FEEDILNISL SILDRSLNFR RDPVTDVARR NDPKYVCRVL SAMINGNDDN GVISGNWSGN 

       250        260        270        280        290        300 
YTGGVDPRTW NGSVEILKNW KKSGFRPVQF GQCWVFAGTL NTVLRCLGVR SRVITNFNSA 

       310        320        330        340        350        360 
HDTDRNLSVD VYYDAMGNPL EKGSDSVWNF HVWNEGWFVR TDLGPTYNGW QVLDATPQER 

       370        380        390        400        410        420 
SQGVFQCGPA SVNAIKAGDV DRNFDMIFIF AEVNADRITW IYNNRNNTQK QNSVDTHSIG 

       430        440        450        460        470        480 
KYISTKAVGS NSRMDVTDKY KYPEGSSEER QVHQKALDKL KPNASFGATS SRNPEGEDKE 

       490        500        510        520        530        540 
PSISGKFKVT GILAVGKEVS LSLMLKNMTN DRKTVTMNMT AWTIVYNGTL VHEVWKDSAT 

       550        560        570        580        590        600 
ISLDPEEEIQ YPVKIAYSQY ERYLKADNMI RISAVCKVPD EAEVVVEWDV ILDNPALTLE 

       610        620        630        640        650        660 
VLEQAHVRKP VNVQMIFSNP LDQPVNNCVL LVEGSGCSVA ASRLMCHPCV PKEKSRIRFE 

       670        680        690 
IFPTRSGTKQ LLADFSCNKF PTIKAMLPID VSE
Q08189 in FASTA format

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