[1]
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NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Liver;
PubMed=3266596 [NCBI, ExPASy, EBI, Israel, Japan]
Herz J.,
Hamann U.,
Rogne S.,
Myklebost O.,
Gausepohl H.,
Stanley K.K.;
"Surface location and high affinity for calcium of a 500-kd liver membrane protein closely related to the LDL-receptor suggest a physiological role as lipoprotein receptor.";
EMBO J. 7:4119-4127(1988).
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[2]
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NUCLEOTIDE SEQUENCE [GENOMIC DNA].
DOI=10.1006/geno.1994.1584; PubMed=7534747 [NCBI, ExPASy, EBI, Israel, Japan]
Van Leuven F.,
Stas L.,
Hilliker C.,
Lorent K.,
Umans L.,
Serneels L.,
Overbergh L.,
Torrekens S.,
Moechars D.,
De Strooper B.,
Van den Berghe H.;
"Structure of the gene (LRP1) coding for the human alpha 2-macroglobulin receptor lipoprotein receptor-related protein.";
Genomics 24:78-89(1994).
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[3]
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NUCLEOTIDE SEQUENCE [GENOMIC DNA].
DOI=10.1006/geno.1998.5408; PubMed=9782078 [NCBI, ExPASy, EBI, Israel, Japan]
Van Leuven F.,
Stas L.,
Thiry E.,
Nelissen B.,
Miyake Y.;
"Strategy to sequence the 89 exons of the human LRP1 gene coding for the lipoprotein receptor related protein: identification of one expressed mutation among 48 polymorphisms.";
Genomics 52:138-144(1998).
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[4]
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NUCLEOTIDE SEQUENCE [GENOMIC DNA].
NHLBI resequencing and genotyping service (RS&G);
Submitted (DEC-2005) to the EMBL/GenBank/DDBJ databases.
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[5]
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NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-11.
TISSUE=Blood;
Glaeser C.;
Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases.
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[6]
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NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-11.
PubMed=2597675 [NCBI, ExPASy, EBI, Israel, Japan]
Kutt H.,
Herz J.,
Stanley K.K.;
"Structure of the low-density lipoprotein receptor-related protein (LRP) promoter.";
Biochim. Biophys. Acta 1009:229-236(1989).
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[7]
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PROTEIN SEQUENCE OF 150-166; 234-252; 685-695; 902-916; 1096-1109; 1743-1756; 2863-2874; 2949-2960; 3023-3039 AND 3277-3291.
TISSUE=Placenta;
PubMed=1698775 [NCBI, ExPASy, EBI, Israel, Japan]
Strickland D.K.,
Ashcom J.D.,
Williams S.,
Burgess W.H.,
Migliorini M.,
Argraves W.S.;
"Sequence identity between the alpha 2-macroglobulin receptor and low density lipoprotein receptor-related protein suggests that this molecule is a multifunctional receptor.";
J. Biol. Chem. 265:17401-17404(1990).
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[8]
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PROTEOLYTIC PROCESSING.
PubMed=2112085 [NCBI, ExPASy, EBI, Israel, Japan]
Herz J.,
Kowal R.C.,
Goldstein J.L.,
Brown M.S.;
"Proteolytic processing of the 600 kd low density lipoprotein receptor-related protein (LRP) occurs in a trans-Golgi compartment.";
EMBO J. 9:1769-1776(1990).
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[9]
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FUNCTION.
DOI=10.1016/0014-5793(90)80530-V; PubMed=1702392 [NCBI, ExPASy, EBI, Israel, Japan]
Kristensen T.,
Moestrup S.K.,
Gliemann J.,
Bendtsen L.,
Sand O.,
Sottrup-Jensen L.;
"Evidence that the newly cloned low-density-lipoprotein receptor related protein (LRP) is the alpha 2-macroglobulin receptor.";
FEBS Lett. 276:151-155(1990).
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[10]
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INTERACTION WITH GULP1, AND MUTAGENESIS OF ASN-4470 AND ASN-4504.
DOI=10.1074/jbc.M109336200; PubMed=11729193 [NCBI, ExPASy, EBI, Israel, Japan]
Su H.P.,
Nakada-Tsukui K.,
Tosello-Trampont A.-C.,
Li Y.,
Bu G.,
Henson P.M.,
Ravichandran K.S.;
"Interaction of CED-6/GULP, an adapter protein involved in engulfment of apoptotic cells with CED-1 and CD91/low density lipoprotein receptor-related protein (LRP).";
J. Biol. Chem. 277:11772-11779(2002).
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[11]
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PHOSPHORYLATION AT TYR-4507, MUTAGENESIS OF 4470-ASN--TYR-4473 AND 4504-ASN--TYR-4507, AND INTERACTION WITH PDGF.
DOI=10.1074/jbc.M200427200; PubMed=11854294 [NCBI, ExPASy, EBI, Israel, Japan]
Loukinova E.,
Ranganathan S.,
Kuznetsov S.,
Gorlatova N.,
Migliorini M.M.,
Loukinov D.,
Ulery P.G.,
Mikhailenko I.,
Lawrence D.A.,
Strickland D.K.;
"Platelet-derived growth factor (PDGF)-induced tyrosine phosphorylation of the low density lipoprotein receptor-related protein (LRP). Evidence for integrated co-receptor function betwenn LRP and the PDGF.";
J. Biol. Chem. 277:15499-15506(2002).
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[12]
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FUNCTION, AND PROTEOLYTIC PROCESSING.
DOI=10.1074/jbc.M201979200; PubMed=11907044 [NCBI, ExPASy, EBI, Israel, Japan]
May P.,
Reddy Y.K.,
Herz J.;
"Proteolytic processing of low density lipoprotein receptor-related protein mediates regulated release of its intracellular domain.";
J. Biol. Chem. 277:18736-18743(2002).
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[13]
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FUNCTION, AND SUBCELLULAR LOCATION.
DOI=10.1074/jbc.M306403200; PubMed=12888553 [NCBI, ExPASy, EBI, Israel, Japan]
Kinoshita A.,
Shah T.,
Tangredi M.M.,
Strickland D.K.,
Hyman B.T.;
"The intracellular domain of the low density lipoprotein receptor-related protein modulates transactivation mediated by amyloid precursor protein and Fe65.";
J. Biol. Chem. 278:41182-41188(2003).
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[14]
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FUNCTION.
PubMed=12713657 [NCBI, ExPASy, EBI, Israel, Japan]
May P.,
Herz J.;
"LDL receptor-related proteins in neurodevelopment.";
Traffic 4:291-301(2003).
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[15]
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PHOSPHORYLATION AT THR-4460; SER-4517; SER-4520 AND SER-4523, MUTAGENESIS OF THR-4460; THR-4472; SER-4517; SER-4520 AND SER-4523, AND INTERACTION WITH SHC1; GULP1 AND DAB1.
DOI=10.1074/jbc.M407592200; PubMed=15272003 [NCBI, ExPASy, EBI, Israel, Japan]
Ranganathan S.,
Liu C.-X.,
Migliorini M.M.,
Von Arnim C.A.F.,
Peltan I.D.,
Mikhailenko I.,
Hyman B.T.,
Strickland D.K.;
"Serine and threonine phosphorylation of the low density lipoprotein receptor-related protein by protein kinase Calpha regulates endocytosis and association with adaptor molecules.";
J. Biol. Chem. 279:40536-40544(2004).
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[16]
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INTERACTION WITH SNX17.
DOI=10.1016/j.jmb.2005.02.004; PubMed=15769472 [NCBI, ExPASy, EBI, Israel, Japan]
Knauth P.,
Schlueter T.,
Czubayko M.,
Kirsch C.,
Florian V.,
Schreckenberger S.,
Hahn H.,
Bohnensack R.;
"Functions of sorting nexin 17 domains and recognition motif for P-selectin trafficking.";
J. Mol. Biol. 347:813-825(2005).
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[17]
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GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-446; ASN-729; ASN-2127 AND ASN-3048, AND MASS SPECTROMETRY.
TISSUE=Plasma;
DOI=10.1021/pr0502065; PubMed=16335952 [NCBI, ExPASy, EBI, Israel, Japan]
Liu T.,
Qian W.-J.,
Gritsenko M.A.,
Camp D.G. II,
Monroe M.E.,
Moore R.J.,
Smith R.D.;
"Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.";
J. Proteome Res. 4:2070-2080(2005).
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[18]
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IDENTIFICATION IN A COMPLEX WITH CUBN AND PID1, AND INTERACTION WITH CUBN AND PID1.
DOI=10.1074/mcp.M600289-MCP200; PubMed=17124247 [NCBI, ExPASy, EBI, Israel, Japan]
Caratu G.,
Allegra D.,
Bimonte M.,
Schiattarella G.G.,
D'Ambrosio C.,
Scaloni A.,
Napolitano M.,
Russo T.,
Zambrano N.;
"Identification of the ligands of protein interaction domains through a functional approach.";
Mol. Cell. Proteomics 6:333-345(2007).
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[19]
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STRUCTURE BY NMR OF 1059-1100 IN COMPLEX WITH CALCIUM IONS, AND DISULFIDE BONDS.
DOI=10.1074/jbc.274.20.14130; PubMed=10318830 [NCBI, ExPASy, EBI, Israel, Japan]
Huang W.,
Dolmer K.,
Gettins P.G.W.;
"NMR solution structure of complement-like repeat CR8 from the low density lipoprotein receptor-related protein.";
J. Biol. Chem. 274:14130-14136(1999).
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[20]
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STRUCTURE BY NMR OF 851-893 IN COMPLEX WITH CALCIUM IONS, AND DISULFIDE BONDS.
DOI=10.1074/jbc.275.5.3264; PubMed=10652313 [NCBI, ExPASy, EBI, Israel, Japan]
Dolmer K.,
Huang W.,
Gettins P.G.W.;
"NMR solution structure of complement-like repeat CR3 from the low density lipoprotein receptor-related protein. Evidence for specific binding to the receptor binding domain of human alpha(2)-macroglobulin.";
J. Biol. Chem. 275:3264-3269(2000).
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[21]
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X-RAY CRYSTALLOGRAPHY (1.85 ANGSTROMS) OF 1012-1054 IN COMPLEX WITH CALCIUM IONS, AND DISULFIDE BONDS.
DOI=10.1021/bi015688m; PubMed=11735395 [NCBI, ExPASy, EBI, Israel, Japan]
Simonovic M.,
Dolmer K.,
Huang W.,
Strickland D.K.,
Volz K.,
Gettins P.G.;
"Calcium coordination and pH dependence of the calcium affinity of ligand-binding repeat CR7 from the LRP. Comparison with related domains from the LRP and the LDL receptor.";
Biochemistry 40:15127-15134(2001).
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[22]
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STRUCTURE BY NMR OF 932-1013 IN COMPLEX WITH LRPAP1 AND CALCIUM IONS, AND DISULFIDE BONDS.
DOI=10.1016/j.jmb.2006.07.013; PubMed=16938309 [NCBI, ExPASy, EBI, Israel, Japan]
Jensen G.A.,
Andersen O.M.J.J.,
Bonvin A.M.,
Bjerrum-Bohr I.,
Etzerodt M.,
Thoegersen H.C.,
O'Shea C.,
Poulsen F.M.,
Kragelund B.B.;
"Binding site structure of one LRP-RAP complex: implications for a common ligand-receptor binding motif.";
J. Mol. Biol. 362:700-716(2006).
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[23]
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VARIANTS [LARGE SCALE ANALYSIS] LYS-869 AND HIS-3760.
DOI=10.1126/science.1133427; PubMed=16959974 [NCBI, ExPASy, EBI, Israel, Japan]
Sjoeblom T.,
Jones S.,
Wood L.D.,
Parsons D.W.,
Lin J.,
Barber T.D.,
Mandelker D.,
Leary R.J.,
Ptak J.,
Silliman N.,
Szabo S.,
Buckhaults P.,
Farrell C.,
Meeh P.,
Markowitz S.D.,
Willis J.,
Dawson D.,
Willson J.K.V.,
Gazdar A.F., ![]()
Hartigan J.,
Wu L.,
Liu C.,
Parmigiani G.,
Park B.H.,
Bachman K.E.,
Papadopoulos N.,
Vogelstein B.,
Kinzler K.W.,
Velculescu V.E.;
"The consensus coding sequences of human breast and colorectal cancers.";
Science 314:268-274(2006).
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