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[1]
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NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), AND PROTEIN SEQUENCE OF 1-6.
TISSUE=Testis;
PubMed=8454611 [NCBI, ExPASy, EBI, Israel, Japan]
Graves P.R.,
Haas D.W.,
Hagedorn C.H.,
Depaoli-Roach A.A.,
Roach P.J.;
"Molecular cloning, expression, and characterization of a 49-kilodalton casein kinase I isoform from rat testis.";
J. Biol. Chem. 268:6394-6401(1993).
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[2]
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NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
Takano A.,
Nagai K.;
"Casein kinase 1 delta rat.";
Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases.
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[3]
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AUTOPHOSPHORYLATION, AND AUTOINHIBITORY DOMAIN.
DOI=10.1074/jbc.270.37.21689; PubMed=7665585 [NCBI, ExPASy, EBI, Israel, Japan]
Graves P.R.,
Roach P.J.;
"Role of COOH-terminal phosphorylation in the regulation of casein kinase I delta.";
J. Biol. Chem. 270:21689-21694(1995).
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[4]
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TISSUE SPECIFICITY.
DOI=10.1016/S0014-5793(00)02434-0; PubMed=11165242 [NCBI, ExPASy, EBI, Israel, Japan]
Camacho F.,
Cilio M.,
Guo Y.,
Virshup D.M.,
Patel K.,
Khorkova O.,
Styren S.,
Morse B.,
Yao Z.,
Keesler G.A.;
"Human casein kinase Idelta phosphorylation of human circadian clock proteins period 1 and 2.";
FEBS Lett. 489:159-165(2001).
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[5]
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X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS) OF 1-317.
DOI=10.1006/jmbi.1996.0189; PubMed=8648628 [NCBI, ExPASy, EBI, Israel, Japan]
Longenecker K.L.,
Roach P.J.,
Hurley T.D.;
"Three-dimensional structure of mammalian casein kinase I: molecular basis for phosphate recognition.";
J. Mol. Biol. 257:618-631(1996).
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- FUNCTION: Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Central component of the circadian clock. May act as a negative regulator of circadian rhythmicity by phosphorylating PER1 and PER2. Retains PER1 in the cytoplasm (By similarity).
- CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein.
- ENZYME REGULATION: Exhibits substrate-dependent heparin activation.
- SUBUNIT: Monomer. Component of the circadian core oscillator, which includes the CRY proteins, CLOCK, or NPAS2, BMAL1 or BMAL2, CSNK1D and/or CSNK1E, TIMELESS and the PER proteins. Interacts directly with PER1 and PER2 which may lead to their degradation.
- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
- ALTERNATIVE PRODUCTS:
2 named isoforms [FASTA] produced by alternative splicing.
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| Name | 2 |
| Isoform ID | Q06486-2 |
| Features which should be applied to build the isoform sequence: VSP_010255. |
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- TISSUE SPECIFICITY: Expressed in most tissues, including heart, brain, testis, kidney, spleen and lung.
- DOMAIN: The autoinhibitory domain is involved in regulating enzyme activity through autophosphorylation and possibly, through heparin binding.
- PTM: Autophosphorylated on serine and threonine residues.
- SIMILARITY: Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.
- SIMILARITY: Contains 1 protein kinase domain.
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Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms.
Distributed under the Creative Commons Attribution-NoDerivs License.
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| Length: 415 AA [This is the length of the unprocessed precursor] |
Molecular weight: 47316 Da [This is the MW of the unprocessed precursor] |
CRC64: B97F04AF9EB466D2 [This is a checksum on the sequence] |
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10 20 30 40 50 60
MELRVGNRYR LGRKIGSGSF GDIYLGTDIA AGEEVAIKLE CVKTKHPQLH IESKIYKMMQ
70 80 90 100 110 120
GGVGIPTIRW CGAEGDYNVM VMELLGPSLE DLFNFCSRKF SLKTVLLLAD QMISRIEYIH
130 140 150 160 170 180
SKNFIHRDVK PDNFLMGLGK KGNLVYIIDF GLAKKYRDAR THQHIPYREN KNLTGTARYA
190 200 210 220 230 240
SINTHLGIEQ SRRDDLESLG YVLMYFNLGS LPWQGLKAAT KRQKYERISE KKMSTPIEVL
250 260 270 280 290 300
CKGYPSEFAT YLNFCRSLRF DDKPDYSYLR QLFRNLFHRQ GFSYDYVFDW NMLKFGASRA
310 320 330 340 350 360
ADDAERERRD REERLRHSRN PATRGLPSTA SGRLRGTQEV APPTPLTPTS HTANTSPRPV
370 380 390 400 410
SGMERERKVS MRLHRGAPVN VSSSDLTGRQ DTSRMSTSQI PGRVASSGLQ SVVHR
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Q06486 in FASTA format |
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