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UniProtKB/Swiss-Prot entry Q06194

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name FA8_MOUSE
Primary accession number Q06194
Secondary accession numbers None
Integrated into Swiss-Prot on June 1, 1994
Sequence was last modified on June 1, 1994 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 74)
Name and origin of the protein
Protein name Coagulation factor VIII [Precursor]
Synonym Procoagulant component
Gene name
Name: F8
Synonyms: Cf8, F8c
From
Mus musculus (Mouse) [TaxID: 10090] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus.
Protein existence 2: Evidence at transcript level;
References
[1]
 NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=C57BL/6 X CBA;
TISSUE=Liver;
DOI=10.1006/geno.1993.1200; PubMed=8314577 [NCBI, ExPASy, EBI, Israel, Japan]
Elder B., Lakich D., Gitschier J.;
"Sequence of the murine factor VIII cDNA.";
Genomics 16:374-379(1993).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
L05573; AAA37385.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR A47004; A47004.
RefSeq NP_032003.1; -.
UniGene Mm.1805
3D structure databases
HSSP P00451; 1D7P. [HSSP ENTRY / PDB]
ModBase Q06194.
PTM databases
PhosphoSite Q06194; -.
Organism-specific databases
MGI MGI:88383; F8.
Gene expression databases
ArrayExpress Q06194; -.
CleanEx MM_F8; -.
GermOnline ENSMUSG00000031196; Mus musculus.
Family and domain databases
InterPro IPR000421; Coagulation_factor_5/8-type_C.
IPR001117; Cu-oxidase.
IPR011706; Cu-oxidase_2.
IPR011707; Cu-oxidase_3.
IPR002355; Cu_oxidase_Cu_BS.
IPR008972; Cupredoxin.
IPR014707; Factor_VIII.
Graphical view of domain structure.
Gene3D G3DSA:2.60.40.420; Cupredoxin; 6.
PANTHER PTHR10127:SF50; Factor_VIII; 1.
Pfam PF00394; Cu-oxidase; 1.
PF07731; Cu-oxidase_2; 1.
PF07732; Cu-oxidase_3; 1.
PF00754; F5_F8_type_C; 2.
Pfam graphical view of domain structure.
SMART SM00231; FA58C; 2.
SMART graphical view of domain structure.
PROSITE PS01285; FA58C_1; 2.
PS01286; FA58C_2; 2.
PS50022; FA58C_3; 2.
PS00079; MULTICOPPER_OXIDASE1; 3.
PROSITE graphical view of domain structure (profiles).
BLOCKS Q06194.
Genome annotation databases
Ensembl ENSMUSG00000031196; Mus musculus. [Contig view]
GeneID 14069; -.
KEGG mmu:14069; -.
Phylogenomic databases
HOGENOM Q06194; -.
HOVERGEN Q06194; -.
Other
SOURCE F8; Mus musculus.
ProtoNet Q06194.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Acute phase; Blood coagulation; Calcium; Glycoprotein; Metal-binding; Repeat; Secreted; Signal; Sulfation.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom    To Length Description FTId
SIGNAL   1     19  19     Potential. 
CHAIN   20   2319  2300     Coagulation factor VIII. PRO_0000002972
DOMAIN   20    349  330     F5/8 type A 1. 
DOMAIN   20    199  180     Plastocyanin-like 1. 
DOMAIN   207    349  143     Plastocyanin-like 2. 
DOMAIN   399    730  332     F5/8 type A 2. 
DOMAIN   399    573  175     Plastocyanin-like 3. 
DOMAIN   583    730  148     Plastocyanin-like 4. 
DOMAIN   1683   2008  326     F5/8 type A 3. 
DOMAIN   1683   1845  163     Plastocyanin-like 5. 
DOMAIN   1855   2008  154     Plastocyanin-like 6. 
DOMAIN   2008   2156  149     F5/8 type C 1. 
DOMAIN   2161   2313  153     F5/8 type C 2. 
REGION   760   1640  881     B. 
SITE   391    392  2     Cleavage; by thrombin (By similarity). 
SITE   759    760  2     Cleavage; by thrombin (By similarity). 
SITE   1324   1325  2     Cleavage (activation) (By similarity). 
SITE   1640   1641  2     Cleavage (activation) (By similarity). 
SITE   1678   1679  2     Cleavage; by thrombin (By similarity). 
MOD_RES   367    367        Sulfotyrosine (By similarity). 
MOD_RES   737    737        Sulfotyrosine (By similarity). 
MOD_RES   738    738        Sulfotyrosine (By similarity). 
MOD_RES   742    742        Sulfotyrosine (By similarity). 
MOD_RES   1669   1669        Sulfotyrosine (By similarity). 
MOD_RES   1687   1687        Sulfotyrosine (By similarity). 
CARBOHYD   61     61        N-linked (GlcNAc...) (Potential). 
CARBOHYD   233    233        N-linked (GlcNAc...) (Potential). 
CARBOHYD   259    259        N-linked (GlcNAc...) (Potential). 
CARBOHYD   423    423        N-linked (GlcNAc...) (Potential). 
CARBOHYD   601    601        N-linked (GlcNAc...) (Potential). 
CARBOHYD   880    880        N-linked (GlcNAc...) (Potential). 
CARBOHYD   958    958        N-linked (GlcNAc...) (Potential). 
CARBOHYD   1015   1015        N-linked (GlcNAc...) (Potential). 
CARBOHYD   1022   1022        N-linked (GlcNAc...) (Potential). 
CARBOHYD   1026   1026        N-linked (GlcNAc...) (Potential). 
CARBOHYD   1044   1044        N-linked (GlcNAc...) (Potential). 
CARBOHYD   1076   1076        N-linked (GlcNAc...) (Potential). 
CARBOHYD   1087   1087        N-linked (GlcNAc...) (Potential). 
CARBOHYD   1136   1136        N-linked (GlcNAc...) (Potential). 
CARBOHYD   1161   1161        N-linked (GlcNAc...) (Potential). 
CARBOHYD   1192   1192        N-linked (GlcNAc...) (Potential). 
CARBOHYD   1255   1255        N-linked (GlcNAc...) (Potential). 
CARBOHYD   1268   1268        N-linked (GlcNAc...) (Potential). 
CARBOHYD   1273   1273        N-linked (GlcNAc...) (Potential). 
CARBOHYD   1274   1274        N-linked (GlcNAc...) (Potential). 
CARBOHYD   1302   1302        N-linked (GlcNAc...) (Potential). 
CARBOHYD   1316   1316        N-linked (GlcNAc...) (Potential). 
CARBOHYD   1340   1340        N-linked (GlcNAc...) (Potential). 
CARBOHYD   1378   1378        N-linked (GlcNAc...) (Potential). 
CARBOHYD   1797   1797        N-linked (GlcNAc...) (Potential). 
CARBOHYD   2105   2105        N-linked (GlcNAc...) (Potential). 
DISULFID   173    199        Probable. 
DISULFID   547    573        Probable. 
DISULFID   1819   1845        Probable. 
DISULFID   2008   2156        By similarity. 
DISULFID   2161   2313        By similarity. 
Sequence information
Length: 2319 AA [This is the length of the unprocessed precursor] Molecular weight: 266150 Da [This is the MW of the unprocessed precursor] CRC64: FD054DE051DB2A01 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MQIALFACFF LSLFNFCSSA IRRYYLGAVE LSWNYIQSDL LSVLHTDSRF LPRMSTSFPF 

        70         80         90        100        110        120 
NTSIMYKKTV FVEYKDQLFN IAKPRPPWMG LLGPTIWTEV HDTVVITLKN MASHPVSLHA 

       130        140        150        160        170        180 
VGVSYWKASE GDEYEDQTSQ MEKEDDKVFP GESHTYVWQV LKENGPMASD PPCLTYSYMS 

       190        200        210        220        230        240 
HVDLVKDLNS GLIGALLVCK EGSLSKERTQ MLYQFVLLFA VFDEGKSWHS ETNDSYTQSM 

       250        260        270        280        290        300 
DSASARDWPK MHTVNGYVNR SLPGLIGCHR KSVYWHVIGM GTTPEIHSIF LEGHTFFVRN 

       310        320        330        340        350        360 
HRQASLEISP ITFLTAQTLL IDLGQFLLFC HISSHKHDGM EAYVKVDSCP EESQWQKKNN 

       370        380        390        400        410        420 
NEEMEDYDDD LYSEMDMFTL DYDSSPFIQI RSVAKKYPKT WIHYISAEEE DWDYAPSVPT 

       430        440        450        460        470        480 
SDNGSYKSQY LSNGPHRIGR KYKKVRFIAY TDETFKTRET IQHESGLLGP LLYGEVGDTL 

       490        500        510        520        530        540 
LIIFKNQASR PYNIYPHGIT DVSPLHARRL PRGIKHVKDL PIHPGEIFKY KWTVTVEDGP 

       550        560        570        580        590        600 
TKSDPRCLTR YYSSFINPER DLASGLIGPL LICYKESVDQ RGNQMMSDKR NVILFSIFDE 

       610        620        630        640        650        660 
NQSWYITENM QRFLPNAAKT QPQDPGFQAS NIMHSINGYV FDSLELTVCL HEVAYWHILS 

       670        680        690        700        710        720 
VGAQTDFLSI FFSGYTFKHK MVYEDTLTLF PFSGETVFMS MENPGLWVLG CHNSDFRKRG 

       730        740        750        760        770        780 
MTALLKVSSC DKSTSDYYEE IYEDIPTQLV NENNVIDPRS FFQNTNHPNT RKKKFKDSTI 

       790        800        810        820        830        840 
PKNDMEKIEP QFEEIAEMLK VQSVSVSDML MLLGQSHPTP HGLFLSDGQE AIYEAIHDDH 

       850        860        870        880        890        900 
SPNAIDSNEG PSKVTQLRPE SHHSEKIVFT PQPGLQLRSN KSLETTIEVK WKKLGLQVSS 

       910        920        930        940        950        960 
LPSNLMTTTI LSDNLKATFE KTDSSGFPDM PVHSSSKLST TAFGKKAYSL VGSHVPLNAS 

       970        980        990       1000       1010       1020 
EENSDSNILD STLMYSQESL PRDNILSIEN DRLLREKRFH GIALLTKDNT LFKDNVSLMK 

      1030       1040       1050       1060       1070       1080 
TNKTYNHSTT NEKLHTESPT SIENSTTDLQ DAILKVNSEI QEVTALIHDG TLLGKNSTYL 

      1090       1100       1110       1120       1130       1140 
RLNHMLNRTT STKNKDIFHR KDEDPIPQDE ENTIMPFSKM LFLSESSNWF KKTNGNNSLN 

      1150       1160       1170       1180       1190       1200 
SEQEHSPKQL VYLMFKKYVK NQSFLSEKNK VTVEQDGFTK NIGLKDMAFP HNMSIFLTTL 

      1210       1220       1230       1240       1250       1260 
SNVHENGRHN QEKNIQEEIE KEALIEEKVV LPQVHEATGS KNFLKDILIL GTRQNISLYE 

      1270       1280       1290       1300       1310       1320 
VHVPVLQNIT SINNSTNTVQ IHMEHFFKRR KDKETNSEGL VNKTREMVKN YPSQKNITTQ 

      1330       1340       1350       1360       1370       1380 
RSKRALGQFR LSTQWLKTIN CSTQCIIKQI DHSKEMKKFI TKSSLSDSSV IKSTTQTNSS 

      1390       1400       1410       1420       1430       1440 
DSHIVKTSAF PPIDLKRSPF QNKFSHVQAS SYIYDFKTKS SRIQESNNFL KETKINNPSL 

      1450       1460       1470       1480       1490       1500 
AILPWNMFID QGKFTSPGKS NTNSVTYKKR ENIIFLKPTL PEESGKIELL PQVSIQEEEI 

      1510       1520       1530       1540       1550       1560 
LPTETSHGSP GHLNLMKEVF LQKIQGPTKW NKAKRHGESI KGKTESSKNT RSKLLNHHAW 

      1570       1580       1590       1600       1610       1620 
DYHYAAQIPK DMWKSKEKSP EIISIKQEDT ILSLRPHGNS HSIGANEKQN WPQRETTWVK 

      1630       1640       1650       1660       1670       1680 
QGQTQRTCSQ IPPVLKRHQR ELSAFQSEQE ATDYDDAITI ETIEDFDIYS EDIKQGPRSF 

      1690       1700       1710       1720       1730       1740 
QQKTRHYFIA AVERLWDYGM STSHVLRNRY QSDNVPQFKK VVFQEFTDGS FSQPLYRGEL 

      1750       1760       1770       1780       1790       1800 
NEHLGLLGPY IRAEVEDNIM VTFKNQASRP YSFYSSLISY KEDQRGEEPR RNFVKPNETK 

      1810       1820       1830       1840       1850       1860 
IYFWKVQHHM APTEDEFDCK AWAYFSDVDL ERDMHSGLIG PLLICHANTL NPAHGRQVSV 

      1870       1880       1890       1900       1910       1920 
QEFALLFTIF DETKSWYFTE NVKRNCKTPC NFQMEDPTLK ENYRFHAING YVMDTLPGLV 

      1930       1940       1950       1960       1970       1980 
MAQDQRIRWY LLSMGNNENI QSIHFSGHVF TVRKKEEYKM AVYNLYPGVF ETLEMIPSRA 

      1990       2000       2010       2020       2030       2040 
GIWRVECLIG EHLQAGMSTL FLVYSKQCQI PLGMASGSIR DFQITASGHY GQWAPNLARL 

      2050       2060       2070       2080       2090       2100 
HYSGSINAWS TKEPFSWIKV DLLAPMIVHG IKTQGARQKF SSLYISQFII MYSLDGKKWL 

      2110       2120       2130       2140       2150       2160 
SYQGNSTGTL MVFFGNVDSS GIKHNSFNPP IIARYIRLHP THSSIRSTLR MELMGCDLNS 

      2170       2180       2190       2200       2210       2220 
CSIPLGMESK VISDTQITAS SYFTNMFATW SPSQARLHLQ GRTNAWRPQV NDPKQWLQVD 

      2230       2240       2250       2260       2270       2280 
LQKTMKVTGI ITQGVKSLFT SMFVKEFLIS SSQDGHHWTQ ILYNGKVKVF QGNQDSSTPM 

      2290       2300       2310 
MNSLDPPLLT RYLRIHPQIW EHQIALRLEI LGCEAQQQY
Q06194 in FASTA format

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