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UniProtKB/Swiss-Prot entry Q047M6

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name PYRC_LACDB
Primary accession number Q047M6
Secondary accession numbers None
Integrated into Swiss-Prot on January 15, 2008
Sequence was last modified on November 14, 2006 (Sequence version 1)
Annotations were last modified on    September 2, 2008 (Entry version 18)
Name and origin of the protein
Protein name Dihydroorotase
Synonyms DHOase
EC 3.5.2.3
Gene name
Name: pyrC
OrderedLocusNames: LBUL_1952
From
Lactobacillus delbrueckii subsp. bulgaricus (strain ATCC BAA-365) [TaxID: 321956] [HAMAP proteome]
Taxonomy Bacteria; Firmicutes; Lactobacillales; Lactobacillaceae; Lactobacillus.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1073/pnas.0607117103; PubMed=17030793 [NCBI, ExPASy, EBI, Israel, Japan]
Makarova K.S., Slesarev A., Wolf Y.I., Sorokin A., Mirkin B., Koonin E.V., Pavlov A., Pavlova N., Karamychev V., Polouchine N., Shakhova V., Grigoriev I., Lou Y., Rohksar D., Lucas S., Huang K., Goodstein D.M., Hawkins T., Plengvidhya V., Welker D., Hughes J., Goh Y., Benson A., Baldwin K., Lee J.-H., Diaz-Muniz I., Dosti B., Smeianov V., Wechter W., Barabote R., Lorca G., Altermann E., Barrangou R., Ganesan B., Xie Y., Rawsthorne H., Tamir D., Parker C., Breidt F., Broadbent J.R., Hutkins R., O'Sullivan D., Steele J., Unlu G., Saier M.H. Jr., Klaenhammer T., Richardson P., Kozyavkin S., Weimer B.C., Mills D.A.;
"Comparative genomics of the lactic acid bacteria.";
Proc. Natl. Acad. Sci. U.S.A. 103:15611-15616(2006).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
CP000412; ABJ59346.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq YP_813784.1; -.
3D structure databases
ModBase Q047M6.
Protein family/group databases
MEROPS M38.972; -.
Ontologies
GO
GO:0004151; Molecular function: dihydroorotase activity (inferred from electronic annotation from HAMAP).
GO:0008270; Molecular function: zinc ion binding (inferred from electronic annotation from HAMAP).
GO:0006221; Biological process: pyrimidine nucleotide biosynthetic process (inferred from electronic annotation from HAMAP).
QuickGo view.
Family and domain databases
HAMAP MF_00220; -; 1.
PBIL [Tree]
InterPro IPR006680; Amidohydro_1.
IPR004722; DHOmult.
IPR002195; Dihydroorotase_CS.
Graphical view of domain structure.
Pfam PF01979; Amidohydro_1; 1.
Pfam graphical view of domain structure.
ProDom PD000518; DHOase; 1.
[Domain structure / List of seq. sharing at least 1 domain]
TIGRFAMs TIGR00857; pyrC_multi; 1.
PROSITE PS00482; DIHYDROOROTASE_1; FALSE_NEG.
PS00483; DIHYDROOROTASE_2; 1.
BLOCKS Q047M6.
Genome annotation databases
GeneID 4434751; -.
GenomeReviews CP000412_GR; LBUL_1952.
KEGG lbu:LBUL_1952; -.
CMR Q047M6; LBUL_1952.
Other
ProtoNet Q047M6.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; Hydrolase; Metal-binding; Pyrimidine biosynthesis; Zinc.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   425  425     Dihydroorotase. PRO_1000024088
METAL   56    56        Zinc 1 (By similarity). 
METAL   58    58        Zinc 1 (By similarity). 
METAL   138   138        Zinc 1; via carbamate group (By similarity). 
METAL   138   138        Zinc 2; via carbamate group (By similarity). 
METAL   175   175        Zinc 2 (By similarity). 
METAL   228   228        Zinc 2 (By similarity). 
METAL   301   301        Zinc 1 (By similarity). 
MOD_RES   138   138        N6-carboxylysine (By similarity). 
Sequence information
Length: 425 AA [This is the length of the unprocessed precursor] Molecular weight: 46301 Da [This is the MW of the unprocessed precursor] CRC64: C9EF52A40DE91371 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MQTVIKNGTV YQNGRLIHAD VLIEDQKIKA IGTDLTGDKV IDATGKLVSP GLVDVHVHYR 

        70         80         90        100        110        120 
DPGQTYKEDI ETGSKAAAHG GFTTVGAMPN VTPVPDTPDL MKKMVQENKQ KGIVHIFQYG 

       130        140        150        160        170        180 
PITKNETTDE LPDYAALKKA GAFALSNDGH GVQTAQTMYL AMQEAKKNDL IVAAHAQDDS 

       190        200        210        220        230        240 
LFNHGIVNEG EKAKELNLPP VTELAETTQI ARDLLLAEKT GVHYHICHVS TKTSVELVRI 

       250        260        270        280        290        300 
AKACGINVTC EAAPHHLLLT EDDIPKDNGY YKMNPPLRSK EDQVALLVGL LDGTIDLIAT 

       310        320        330        340        350        360 
DHAPHAKQEK QGGMQNAAFG ITGSETAFST LYTKFVKEDK VFTLEQLLSW LSDQPAKVFG 

       370        380        390        400        410        420 
LKKAGVLEPG CPADVAIFDL EHETELKEKN YQSKGINTPF TGQKIYGATV MTMVDGEVVY 


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Q047M6 in FASTA format

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