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UniProtKB/Swiss-Prot entry Q043B0

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name PYRC_LACGA
Primary accession number Q043B0
Secondary accession numbers None
Integrated into Swiss-Prot on January 15, 2008
Sequence was last modified on November 14, 2006 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 18)
Name and origin of the protein
Protein name Dihydroorotase
Synonyms DHOase
EC 3.5.2.3
Gene name
Name: pyrC
OrderedLocusNames: LGAS_1089
From
Lactobacillus gasseri (strain ATCC 33323 / DSM 20243) [TaxID: 324831] [HAMAP proteome]
Taxonomy Bacteria; Firmicutes; Lactobacillales; Lactobacillaceae; Lactobacillus.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1073/pnas.0607117103; PubMed=17030793 [NCBI, ExPASy, EBI, Israel, Japan]
Makarova K.S., Slesarev A., Wolf Y.I., Sorokin A., Mirkin B., Koonin E.V., Pavlov A., Pavlova N., Karamychev V., Polouchine N., Shakhova V., Grigoriev I., Lou Y., Rohksar D., Lucas S., Huang K., Goodstein D.M., Hawkins T., Plengvidhya V., Welker D., Hughes J., Goh Y., Benson A., Baldwin K., Lee J.-H., Diaz-Muniz I., Dosti B., Smeianov V., Wechter W., Barabote R., Lorca G., Altermann E., Barrangou R., Ganesan B., Xie Y., Rawsthorne H., Tamir D., Parker C., Breidt F., Broadbent J.R., Hutkins R., O'Sullivan D., Steele J., Unlu G., Saier M.H. Jr., Klaenhammer T., Richardson P., Kozyavkin S., Weimer B.C., Mills D.A.;
"Comparative genomics of the lactic acid bacteria.";
Proc. Natl. Acad. Sci. U.S.A. 103:15611-15616(2006).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
CP000413; ABJ60462.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq YP_814900.1; -.
3D structure databases
ModBase Q043B0.
Ontologies
GO
GO:0004151; Molecular function: dihydroorotase activity (inferred from electronic annotation from HAMAP).
GO:0008270; Molecular function: zinc ion binding (inferred from electronic annotation from HAMAP).
GO:0006221; Biological process: pyrimidine nucleotide biosynthetic process (inferred from electronic annotation from HAMAP).
QuickGo view.
Family and domain databases
HAMAP MF_00220; -; 1.
PBIL [Tree]
InterPro IPR006680; Amidohydro_1.
IPR004722; DHOmult.
IPR002195; Dihydroorotase_CS.
Graphical view of domain structure.
Pfam PF01979; Amidohydro_1; 1.
Pfam graphical view of domain structure.
ProDom PD000518; DHOase; 1.
[Domain structure / List of seq. sharing at least 1 domain]
TIGRFAMs TIGR00857; pyrC_multi; 1.
PROSITE PS00482; DIHYDROOROTASE_1; FALSE_NEG.
PS00483; DIHYDROOROTASE_2; 1.
BLOCKS Q043B0.
Genome annotation databases
GeneID 4439692; -.
GenomeReviews CP000413_GR; LGAS_1089.
KEGG lga:LGAS_1089; -.
NMPDR fig|1596.1.peg.166; -.
Phylogenomic databases
HOGENOM Q043B0; -.
Genome annotation databases
CMR Q043B0; LGAS_1089.
Other
ProtoNet Q043B0.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; Hydrolase; Metal-binding; Pyrimidine biosynthesis; Zinc.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   425  425     Dihydroorotase. PRO_1000024089
METAL   56    56        Zinc 1 (By similarity). 
METAL   58    58        Zinc 1 (By similarity). 
METAL   138   138        Zinc 1 (via carbamate group) (By similarity). 
METAL   138   138        Zinc 2 (via carbamate group) (By similarity). 
METAL   175   175        Zinc 2 (By similarity). 
METAL   228   228        Zinc 2 (By similarity). 
METAL   301   301        Zinc 1 (By similarity). 
MOD_RES   138   138        N6-carboxylysine (By similarity). 
Sequence information
Length: 425 AA [This is the length of the unprocessed precursor] Molecular weight: 46019 Da [This is the MW of the unprocessed precursor] CRC64: 6C2EBCDBB17D9C33 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MATVIKNGTV YQNGRLIKAD VLIEGKKIKA IGTDLDAEKI IDAQGMLVSP GLVDVHVHYR 

        70         80         90        100        110        120 
DPGQTYKEDI KTGSEAAARG GFTTVGAMPN VTPVPNTPEL MKKMVEENKH KGVVHIFQYG 

       130        140        150        160        170        180 
PITNDETTDI IPDYAALKKA GAFALSNDGH GVQTAQTMYL AMQKAKENNL IIATHAQDDS 

       190        200        210        220        230        240 
LFNKGIVNEG VAAKKLDLPP VTELAETTQI ARDLLLAQKT GVHYHICHVS TKTSVELVRL 

       250        260        270        280        290        300 
AKARGINVTC EVAPHHILLT DSDIPKDNGY FKMNPPLRNK EDQAALLVGL LDGTIDLIAT 

       310        320        330        340        350        360 
DHAPHAKSEK QGGMKNAAFG ITGSETAFST LYTKFVKEEK VLSLEQLLAL LSDKPAKVFG 

       370        380        390        400        410        420 
IENAGVLEPG KNADVAIFDI EHKNEIKEAD FKSKGVNTPF TGQKVYGETV MTLVDGEVVY 


QRGTK
Q043B0 in FASTA format

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