[1]	NUCLEOTIDE SEQUENCE [GENOMIC DNA]. DOI=10.1007/BF00205823; PubMed=1680099 [NCBI, ExPASy, EBI, Israel, Japan] Peelman L.J., van de Weghe A.R., Coppieters W.R., van Zeveren A.J., Bouquet Y.H.; "Cloning and sequencing of the porcine complement factor B."; Immunogenetics 34:192-195(1991).

Comments

FUNCTION: Factor B which is part of the alternate pathway of the complement system is cleaved by factor D into 2 fragments: Ba and Bb. Bb, a serine protease, then combines with complement factor 3b to generate the C3 or C5 convertase.
CATALYTIC ACTIVITY: Cleavage of Arg-|-Ser bond in complement component C3 alpha-chain to yield C3a and C3b, and Arg-|-Xaa bond in complement component C5 alpha-chain to yield C5a and C5b.
SUBUNIT: Monomer (By similarity).
SUBCELLULAR LOCATION: Secreted.
SIMILARITY: Belongs to the peptidase S1 family [view classification].
SIMILARITY: Contains 3 Sushi (CCP/SCR) domains.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

M59240; AAA31021.1; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

3D structure databases

HSSP

P08174; 1H03. [HSSP ENTRY / PDB]

SMR

Q03710; 1-144.

ModBase

Q03710.

Protein family/group databases

MEROPS

S01.196; -.

Ontologies

GO:0005576;	Cellular component: extracellular region (inferred from electronic annotation from UniProtKB-KW).
GO:0004252;	Molecular function: serine-type endopeptidase activity (inferred from electronic annotation from UniProtKB-KW).
GO:0006957;	Biological process: complement activation, alternative pathway (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.

Family and domain databases

InterPro

IPR016060; Complement_control_module.
IPR001254; Peptidase_S1_S6.
IPR000436; Sushi_SCR_CCP.
Graphical view of domain structure.

Gene3D

G3DSA:2.10.70.10; Complement_control_module; 2.

Pfam

PF00084; Sushi; 2.
Pfam graphical view of domain structure.

SMART

SM00032; CCP; 2.
SMART graphical view of domain structure.

PROSITE

PS50923; SUSHI; 2.
PS50240; TRYPSIN_DOM; PARTIAL.
PS00134; TRYPSIN_HIS; PARTIAL.
PS00135; TRYPSIN_SER; PARTIAL.
PROSITE graphical view of domain structure (profiles).

ProtoNet

Q03710.

Phylogenomic databases

HOVERGEN

Q03710; -.

Other

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Complement alternate pathway; Glycoprotein; Hydrolase; Immune response; Innate immunity; Protease; Repeat; Secreted; Serine protease; Sushi.

Features

Feature table viewer

Feature aligner

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`<1 >151`	`>151`	`Complement factor B.`	`PRO_0000088663`
`DOMAIN`	`1 61`	`61`	`Sushi 2.`
`DOMAIN`	`64 121`	`58`	`Sushi 3.`
`CARBOHYD`	`23 23`		`N-linked (GlcNAc...) (Potential).`
`CARBOHYD`	`43 43`		`N-linked (GlcNAc...) (Potential).`
`DISULFID`	`4 46`		`By similarity.`
`DISULFID`	`32 59`		`By similarity.`
`DISULFID`	`66 106`		`By similarity.`
`DISULFID`	`92 119`		`By similarity.`
`NON_TER`	`1 1`
`NON_TER`	`151 151`

Sequence information

Length: 151 AA [This is the length of the partial sequence of the unprocessed precursor]

Molecular weight: 16765 Da [This is the MW of the partial sequence of the unprocessed precursor]

CRC64: BD247E75047E517F [This is a checksum on the sequence]

        10         20         30         40         50         60 
AIRCPRPHDF ENGEYWPRAP YYNLSDEISF HCYDGYTLRG SANRTCQVTG RWDGQTAICD 

        70         80         90        100        110        120 
DGAGYCPNPG IPIGTRKVGT QYRLEDSVTY YCTRGLTLRG SQRRTCQEGG SWSGTEPSCQ 

       130        140        150 
DSFMYDTPAE VAEAFLSSLT ETIEGVDAED G

Q03710 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools