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UniProtKB/Swiss-Prot entry Q03577

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name SYDC_CAEEL
Primary accession number Q03577
Secondary accession numbers None
Integrated into Swiss-Prot on October 1, 1993
Sequence was last modified on October 1, 1993 (Sequence version 1)
Annotations were last modified on    November 25, 2008 (Entry version 64)
Name and origin of the protein
Protein name Aspartyl-tRNA synthetase, cytoplasmic
Synonyms EC 6.1.1.12
Aspartate--tRNA ligase
AspRS
Gene name
Name: drs-1
ORFNames: B0464.1
From
Caenorhabditis elegans [TaxID: 6239] 
Taxonomy Eukaryota; Metazoa; Nematoda; Chromadorea; Rhabditida; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis.
Protein existence 2: Evidence at transcript level;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Bristol N2;
DOI=10.1038/368032a0; PubMed=7906398 [NCBI, ExPASy, EBI, Israel, Japan]
Wilson R., Ainscough R., Anderson K., Baynes C., Berks M., Bonfield J., Burton J., Connell M., Copsey T., Cooper J., Coulson A., Craxton M., Dear S., Du Z., Durbin R., Favello A., Fraser A., Fulton L., Gardner A., Green P., Hawkins T., Hillier L., Jier M., Johnston L., Jones M., Kershaw J., Kirsten J., Laisster N., Latreille P., Lightning J., Lloyd C., Mortimore B., O'Callaghan M., Parsons J., Percy C., Rifken L., Roopra A., Saunders D., Shownkeen R., Sims M., Smaldon N., Smith A., Smith M., Sonnhammer E., Staden R., Sulston J., Thierry-Mieg J., Thomas K., Vaudin M., Vaughan K., Waterston R., Watson A., Weinstock L., Wilkinson-Sproat J., Wohldman P.;
"2.2 Mb of contiguous nucleotide sequence from chromosome III of C. elegans.";
Nature 368:32-38(1994).
[2]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Bristol N2;
DOI=10.1126/science.282.5396.2012; PubMed=9851916 [NCBI, ExPASy, EBI, Israel, Japan]
The C. elegans sequencing consortium;
"Genome sequence of the nematode C. elegans: a platform for investigating biology.";
Science 282:2012-2018(1998).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
Z19152; CAA79536.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR S28278; S28278.
RefSeq NP_499089.1; -.
UniGene Cel.7882
3D structure databases
HSSP Q9LCY8; 1N9W. [HSSP ENTRY / PDB]
ModBase Q03577.
Organism-specific databases
WormBase WBGene00001094; drs-1.
WormPep B0464.1; CE00015. [WormPep / WorfDB]
Gene expression databases
ArrayExpress Q03577; -.
Ontologies
GO
GO:0005737; Cellular component: cytoplasm (inferred from electronic annotation from InterPro).
GO:0004815; Molecular function: aspartate-tRNA ligase activity (inferred from electronic annotation from InterPro).
GO:0005524; Molecular function: ATP binding (inferred from electronic annotation from InterPro).
GO:0003676; Molecular function: nucleic acid binding (inferred from electronic annotation from InterPro).
GO:0006422; Biological process: aspartyl-tRNA aminoacylation (inferred from electronic annotation from InterPro).
GO:0009792; Biological process: embryonic development ending in birth or egg hatching (inferred from mutant phenotype from WormBase).
GO:0040007; Biological process: growth (inferred from mutant phenotype from WormBase).
GO:0002119; Biological process: nematode larval development (inferred from mutant phenotype from WormBase).
GO:0000003; Biological process: reproduction (inferred from mutant phenotype from WormBase).
QuickGo view.
Family and domain databases
InterPro IPR004364; aa-tRNA-synt_II.
IPR006195; aa-tRNA-synth_II.
IPR002312; Asp-tRNA-synth_IIb.
IPR004523; Asp-tRNA-synth_IIb_arc/euk.
IPR012340; NA-bd_OB-fold.
IPR004365; NA_bd_OB_tRNA-helicase.
Graphical view of domain structure.
Gene3D G3DSA:2.40.50.140; OB_NA_bd_sub; 1.
PANTHER PTHR22594; aa-tRNA-synt_II; 1.
Pfam PF00152; tRNA-synt_2; 1.
PF01336; tRNA_anti; 1.
Pfam graphical view of domain structure.
PRINTS PR01042; TRNASYNTHASP.
TIGRFAMs TIGR00458; aspS_arch; 1.
PROSITE PS50862; AA_TRNA_LIGASE_II; 1.
PROSITE graphical view of domain structure (profiles).
ProtoNet Q03577.
Genome annotation databases
Ensembl B0464.1; Caenorhabditis elegans. [Contig view]
GeneID 176334; -.
KEGG cel:B0464.1; -.
Other
NextBio 892140; -.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Aminoacyl-tRNA synthetase; ATP-binding; Complete proteome; Cytoplasm; Ligase; Nucleotide-binding; Protein biosynthesis.
Features
SEVIEWER logo Feature table viewer
KeyFrom To Length Description FTId
CHAIN   1   531  531     Aspartyl-tRNA synthetase, cytoplasmic. PRO_0000111013
Sequence information
Length: 531 AA [This is the length of the unprocessed precursor] Molecular weight: 59939 Da [This is the MW of the unprocessed precursor] CRC64: 094E3207DC102733 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MADAAEGEQP KLSKKELNKL ARKAKKDEKA GEKGGNQQQA AAMDQEDASK DFYGSYGLVN 

        70         80         90        100        110        120 
SKEKKVLNFL KVKEINVSNA TKDVWVRGRI HTTRSKGKNC FLVLRQGVYT VQVAMFMNEK 

       130        140        150        160        170        180 
ISKQMLKFVS SISKESIVDV YATINKVDNP IESCTQKDVE LLAQQVFVVS TSAPKLPLQI 

       190        200        210        220        230        240 
EDASRRAPTD EEKASEQENQ LAVVNLDTRL DNRVIDLRTP TSHAIFRIQA GICNQFRNIL 

       250        260        270        280        290        300 
DVRGFVEIMA PKIISAPSEG GANVFEVSYF KGSAYLAQSP QLYKQMAIAG DFEKVYTIGP 

       310        320        330        340        350        360 
VFRAEDSNTH RHMTEFVGLD LEMAFNFHYH EVMETIAEVL TQMFKGLQQN YQDEIAAVGN 

       370        380        390        400        410        420 
QYPAEPFQFC EPPLILKYPD AITLLRENGI EIGDEDDLST PVEKFLGKLV KEKYSTDFYV 

       430        440        450        460        470        480 
LDKFPLSVRP FYTMPDAHDE RYSNSYDMFM RGEEILSGAQ RIHDADMLVE RAKHHQVDLA 

       490        500        510        520        530 
KIQSYIDSFK YGCPPHAGGG IGLERVTMLF LGLHNIRLAS LFPRDPKRLT P
Q03577 in FASTA format

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