[1]	NUCLEOTIDE SEQUENCE [GENOMIC DNA]. PubMed=8383793 [NCBI, ExPASy, EBI, Israel, Japan] Burke W.D., Eickbush D.G., Xiong Y., Jakubczak J.L., Eickbush T.H.; "Sequence relationship of retrotransposable elements R1 and R2 within and between divergent insect species."; Mol. Biol. Evol. 10:163-185(1993).
[2]	NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 534-551. PubMed=1849649 [NCBI, ExPASy, EBI, Israel, Japan] Jakubczak J.L., Burke W.D., Eickbush T.H.; "Retrotransposable elements R1 and R2 interrupt the rRNA genes of most insects."; Proc. Natl. Acad. Sci. U.S.A. 88:3295-3299(1991).

Comments

CATALYTIC ACTIVITY: Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).
SIMILARITY: Contains 1 reverse transcriptase domain.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

L00947; AAA29785.1; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

PIR

H44490; H44490.

3D structure databases

ModBase

Q03274.

Ontologies

GO:0004519;	Molecular function: endonuclease activity (inferred from electronic annotation from UniProtKB-KW).
GO:0003723;	Molecular function: RNA binding (inferred from electronic annotation from InterPro).
GO:0003964;	Molecular function: RNA-directed DNA polymerase activity (inferred from electronic annotation from InterPro).
GO:0006278;	Biological process: RNA-dependent DNA replication (inferred from electronic annotation from InterPro).
GO:0032196;	Biological process: transposition (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.

Family and domain databases

InterPro

IPR000477; DNA_pol_RVTase.
IPR015706; Reverse_transcriptase-related.
Graphical view of domain structure.

PANTHER

PTHR19446; Rev_txptase; 1.

Pfam

PF00078; RVT_1; 1.
Pfam graphical view of domain structure.

PROSITE

PS50878; RT_POL; 1.
PROSITE graphical view of domain structure (profiles).

ProtoNet

Q03274.

Other

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Endonuclease; Hydrolase; Nuclease; Nucleotidyltransferase; RNA-directed DNA polymerase; Transferase; Transposable element.

Features

Feature table viewer

Feature aligner

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`<1 711`	`>711`	`Retrovirus-related Pol polyprotein from type-1 retrotransposable element R2.`	`PRO_0000058500`
`DOMAIN`	`45 323`	`279`	`Reverse transcriptase.`
`REGION`	`444 711`	`268`	`Nucleic acid-binding endonuclease.`
`NON_TER`	`1 1`

Sequence information

Length: 711 AA [This is the length of the partial sequence of the unprocessed precursor]

Molecular weight: 79459 Da [This is the MW of the partial sequence of the unprocessed precursor]

CRC64: EAA25C9085F12D04 [This is a checksum on the sequence]

        10         20         30         40         50         60 
HTYRPIAREE IQCAIKGWKP SAPGSDGLTV QAITRTRLPR NFVQLHLLRG HVPTPWTAMR 

        70         80         90        100        110        120 
TTLIPKDGDL ENPSNWRPIT IASALQRLLH RILAKRLEAA VELHPAQKGY ARIDGTLVNS 

       130        140        150        160        170        180 
LLLDTYISSR REQRKTYNVV SLDVRKAFDT VSHSSICRAL QRLGIDEGTS NYITGSLSDS 

       190        200        210        220        230        240 
TTTIRVGPGS QTRKICIRRG VKQGDPLSPF LFNAVLDELL CSLQSTPGIG GTIGEEKIPV 

       250        260        270        280        290        300 
LAFADDLLLL EDNDVLLPTT LATVANFFRL RGMSLNAKKS VSISVAASGG VCIPRTKPFL 

       310        320        330        340        350        360 
RVDNVLLPVT DRMQTFRYLG HFFGLSGAAK PTVYNLSRWL KCVEAAPLKP EQKLSLIREH 

       370        380        390        400        410        420 
VVPKLLYGLQ NPSVTARTLR DADKLIRTTV KRCLHLHLHT PNQCFYARVR DGGLGLTDLR 

       430        440        450        460        470        480 
RSIPRIMLDR INARRSSDPM AVALFSCPSF DHLRGRLVAL AGDVPPSHFW REAIANHTTT 

       490        500        510        520        530        540 
KGLEAASDDP ASRSWIFRKP YGWSGKDFVR AIHLRTGNLP TKAIPSNPAG ERLCRGGCGK 

       550        560        570        580        590        600 
QATISHVLQR CPVVQPERIR RHNEIARKIA AHCRSKGWTV EEEPHIRHPL GHLYKPDIVI 

       610        620        630        640        650        660 
HREGLPSVVC DVQVSWDGYE PLDEAWRNKQ RTYDHDLFRT AAGRRWPGKT FLHLPAILGA 

       670        680        690        700        710 
RGIWPRCNSE TASALAFTNQ LKASWLHSCL KWDSTLHTSF MRAVWSRQAG A

Q03274 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools