[1]	NUCLEOTIDE SEQUENCE [GENOMIC DNA]. PubMed=8383793 [NCBI, ExPASy, EBI, Israel, Japan] Burke W.D., Eickbush D.G., Xiong Y., Jakubczak J.L., Eickbush T.H.; "Sequence relationship of retrotransposable elements R1 and R2 within and between divergent insect species."; Mol. Biol. Evol. 10:163-185(1993).

Comments

CATALYTIC ACTIVITY: Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).
SIMILARITY: Contains 1 reverse transcriptase domain.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

L00940; AAA30337.1; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

PIR

B44490; B44490.

3D structure databases

ModBase

Q03269.

Ontologies

GO:0004519;	Molecular function: endonuclease activity (inferred from electronic annotation from UniProtKB-KW).
GO:0003723;	Molecular function: RNA binding (inferred from electronic annotation from InterPro).
GO:0003964;	Molecular function: RNA-directed DNA polymerase activity (inferred from electronic annotation from InterPro).
GO:0006278;	Biological process: RNA-dependent DNA replication (inferred from electronic annotation from InterPro).
GO:0032196;	Biological process: transposition (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.

Family and domain databases

InterPro

IPR000477; DNA_pol_RVTase.
IPR015706; Reverse_transcriptase-related.
Graphical view of domain structure.

PANTHER

PTHR19446; Rev_txptase; 1.

Pfam

PF00078; RVT_1; 1.
Pfam graphical view of domain structure.

PROSITE

PS50878; RT_POL; 1.
PROSITE graphical view of domain structure (profiles).

ProtoNet

Q03269.

Other

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Endonuclease; Hydrolase; Nuclease; Nucleotidyltransferase; RNA-directed DNA polymerase; Transferase; Transposable element.

Features

Feature table viewer

Feature aligner

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`<1 337`	`>337`	`Retrovirus-related Pol polyprotein from type-1 retrotransposable element R1.`	`PRO_0000058491`
`DOMAIN`	`<1 118`	`>118`	`Reverse transcriptase.`
`REGION`	`253 337`	`85`	`Nucleic acid-binding endonuclease.`
`NON_TER`	`1 1`

Sequence information

Length: 337 AA [This is the length of the partial sequence of the unprocessed precursor]

Molecular weight: 38330 Da [This is the MW of the partial sequence of the unprocessed precursor]

CRC64: 7961F6A27A0A9788 [This is a checksum on the sequence]

        10         20         30         40         50         60 
GCPQGSISGP YMWNLCMNGL LDRLSAMNER IVAYADDLMI VANGNSRMEM ERMADECMRI 

        70         80         90        100        110        120 
VYEWGREVGV SISEKKTVCI MLKGKLNVDG RRMRVAVAEG TISSIGYVKS ARYLGVCMGE 

       130        140        150        160        170        180 
RMSFADDIRG LITKVMGAIG GLRRVMRKEW GVKKKTAYTW AKGLLLAGVM YGSSVWYEGM 

       190        200        210        220        230        240 
KYKTMRESMN SIQRCAMYAC LRVCRTVSTE AMQVLLGWLP CDLECVKDKC VQGSAWHRND 

       250        260        270        280        290        300 
ESDLVTDAEI AEKRARSCKL MKEREHEIWQ RRWCESTKGR VMHEWLCDVN FACERMWFEP 

       310        320        330 
SLRVGYILTG HGTLNAWLYD RDPLDSAACP CGAPRED

Q03269 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools