[1]	NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Masui A., Fujiwara N., Takagi M., Imanaka T.; "Cloning and nucleotide sequence of degM, the regulatory gene, degM, for minor protease in Bacillus subtilis."; J. Ferment. Bioeng. 74:230-233(1992).

Comments

FUNCTION: Involved in a sensory transduction pathway that enhances the production of minor proteases.
CATALYTIC ACTIVITY: ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
SIMILARITY: Contains 1 histidine kinase domain.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

D10690; BAA01532.1; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

PIR

I39833; I39833.

3D structure databases

ModBase

Q03069.

Ontologies

GO:0016021;	Cellular component: integral to membrane (inferred from electronic annotation from UniProtKB-KW).
GO:0005886;	Cellular component: plasma membrane (inferred from electronic annotation from UniProtKB-KW).
GO:0005524;	Molecular function: ATP binding (inferred from electronic annotation from InterPro).
GO:0000155;	Molecular function: two-component sensor activity (inferred from electronic annotation from InterPro).
GO:0018106;	Biological process: peptidyl-histidine phosphorylation (inferred from electronic annotation from InterPro).
GO:0000160;	Biological process: two-component signal transduction system (phosphorelay) (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.

Family and domain databases

InterPro

IPR003594; ATP_bd_ATPase.
IPR004358; Sig_transdc_His_kin-like_C.
IPR003661; Sig_transdc_His_kin_sub1_dim/P.
IPR005467; Sig_transdc_His_kinase_core.
Graphical view of domain structure.

Pfam

PF02518; HATPase_c; 1.
PF00512; HisKA; 1.
Pfam graphical view of domain structure.

PRINTS

PR00344; BCTRLSENSOR.

SMART

SM00387; HATPase_c; 1.
SM00388; HisKA; 1.
SMART graphical view of domain structure.

PROSITE

PS50109; HIS_KIN; 1.
PROSITE graphical view of domain structure (profiles).

ProtoNet

Q03069.

Other

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Cell membrane; Kinase; Membrane; Phosphoprotein; Transferase; Transmembrane; Two-component regulatory system.

Features

Feature table viewer

Feature aligner

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 373`	`373`	`Sensor protein degM.`	`PRO_0000074754`
`TRANSMEM`	`27 47`	`21`	`Potential.`
`TRANSMEM`	`57 77`	`21`	`Potential.`
`TRANSMEM`	`91 111`	`21`	`Potential.`
`TRANSMEM`	`122 142`	`21`	`Potential.`
`DOMAIN`	`170 370`	`201`	`Histidine kinase.`
`COMPBIAS`	`306 315`	`10`	`Gly-rich.`
`COMPBIAS`	`330 340`	`11`	`Gly-rich.`
`MOD_RES`	`173 173`		`Phosphohistidine; by autocatalysis (By similarity).`

Sequence information

Length: 373 AA [This is the length of the unprocessed precursor]

Molecular weight: 41614 Da [This is the MW of the unprocessed precursor]

CRC64: 6494279E0879294B [This is a checksum on the sequence]

        10         20         30         40         50         60 
MSGAVLLCLF FSINVGNIQW DLRYIPILLA FLYGGKRAGW GVAAIAVVGR IGQGGDLFLL 

        70         80         90        100        110        120 
GVVLIVLTAL FYALCVNRFY MLPPRWSRIR YASLLVILPA TIQTFGTLYL INYENHLSES 

       130        140        150        160        170        180 
WVAGWLYIVF LVVTVVLVTY LFETLLEKER IVAELVATEK DFTKGELAAS IAHEVRNPLT 

       190        200        210        220        230        240 
VVKGFVQLLS EDKQHAEYHK LILSELDRAE SIIYEFLNTT RPQTNATFHL NETAREVVAL 

       250        260        270        280        290        300 
LTPYAQERSI QLTIGTCEQA IVNGNENKVK QALMNFVKNG IEASNEGDTV TIQLDRLKDR 

       310        320        330        340        350        360 
AQIEINDNGV GMSRQQLKQL GTAYFTTKES GNGIGTMVSI RIVEMMNGMV TFKSKPGKGT 

       370 
KVVLSLPIEK ENE

Q03069 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools