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UniProtKB/Swiss-Prot entry Q03052


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name PO3F1_HUMAN
Primary accession number Q03052
Secondary accession number Q5TAG2
Integrated into Swiss-Prot on July 1, 1993
Sequence was last modified on December 16, 2008 (Sequence version 3)
Annotations were last modified on    June 16, 2009 (Entry version 87)
Name and origin of the protein
Protein name POU domain, class 3, transcription factor 1
Synonyms Octamer-binding transcription factor 6
Oct-6
POU domain transcription factor SCIP
Gene name
Name: POU3F1
Synonyms: OCT6, OTF6
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 2: Evidence at transcript level;
References
[1]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=7909356 [NCBI, ExPASy, EBI, Israel, Japan]
Faus I., Hsu H.J., Fuchs E.;
"Oct-6: a regulator of keratinocyte gene expression in stratified squamous epithelia.";
Mol. Cell. Biol. 14:3263-3275(1994).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1038/nature04727; PubMed=16710414 [NCBI, ExPASy, EBI, Israel, Japan]
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K., Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
"The DNA sequence and biological annotation of human chromosome 1.";
Nature 441:315-321(2006).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.;
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
[4]
NUCLEOTIDE SEQUENCE [MRNA] OF 53-451.
DOI=10.1093/nar/21.4.1043; PubMed=8451175 [NCBI, ExPASy, EBI, Israel, Japan]
Tobler A., Schreiber E., Fontana A.;
"The human Oct-6 POU transcription factor lacks the first 50 amino acids of its murine counterpart.";
Nucleic Acids Res. 21:1043-1043(1993).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
L26494; AAA59965.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL139158; CAI23136.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
CH471059; EAX07298.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
Z18284; CAA79158.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
IPI IPI00008840; -.
PIR A56018; A56018.
RefSeq NP_002690.3; -.
UniGene Hs.1837
3D structure databases
HSSP P14859; 1CQT. [HSSP ENTRY / PDB]
SMR Q03052; 250-396.
ModBase Q03052.
Protein-protein interaction databases
DIP DIP:277N; -.
Organism-specific databases
GeneCards GC01M038282; -.
H-InvDB HIX0028895; -.
HGNC HGNC:9214; POU3F1.
GenAtlas POU3F1.
MIM 602479; gene. [NCBI / EBI]
PharmGKB PA33538; -.
Gene expression databases
ArrayExpress Q03052; -.
Bgee Q03052; -.
CleanEx HS_POU3F1; -.
GermOnline ENSG00000185668; Homo sapiens.
Ontologies
GO
GO:0043565; Molecular function: sequence-specific DNA binding (inferred from direct assay from MGI).
GO:0003700; Molecular function: transcription factor activity (traceable author statement from ProtInc).
GO:0006355; Biological process: regulation of transcription, DNA-dependent (inferred from electronic annotation from UniProtKB-KW).
GO:0006350; Biological process: transcription (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR001356; Homeobox.
IPR017970; Homeobox_CS.
IPR012287; Homeodomain-rel.
IPR013847; POU.
IPR000327; POU_specific.
Graphical view of domain structure.
Gene3D G3DSA:1.10.10.60; Homeodomain-rel; 1.
Pfam PF00046; Homeobox; 1.
PF00157; Pou; 1.
Pfam graphical view of domain structure.
PRINTS PR00028; POUDOMAIN.
ProDom PD000010; Homeobox; 1.
PD000583; POU; 1.
[Domain structure / List of seq. sharing at least 1 domain]
SMART SM00389; HOX; 1.
SM00352; POU; 1.
SMART graphical view of domain structure.
PROSITE PS00027; HOMEOBOX_1; 1.
PS50071; HOMEOBOX_2; 1.
PS00035; POU_1; 1.
PS00465; POU_2; 1.
PS51179; POU_3; 1.
PROSITE graphical view of domain structure (profiles).
Proteomic databases
PRIDE Q03052; -.
Genome annotation databases
Ensembl ENSG00000185668; Homo sapiens. [Contig view]
GeneID 5453; -.
NMPDR fig|9606.3.peg.891; -.
Phylogenomic databases
HOVERGEN Q03052; -.
OMA Q03052; HPQWLPT.
Other
SOURCE POU3F1; Homo sapiens.
ProtoNet Q03052.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
DNA-binding; Homeobox; Nucleus; Transcription; Transcription regulation.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   451  451     POU domain, class 3, transcription factor 1. PRO_0000100720
DOMAIN   247   321  75     POU-specific. 
DNA_BIND   339   398  60     Homeobox. 
COMPBIAS   27    45  19     Ala-rich. 
COMPBIAS   59   242  184     Gly-rich. 
COMPBIAS   225   228  4     Poly-Ala. 
COMPBIAS   418   423  6     Poly-Gly. 
COMPBIAS   430   435  6     Poly-Pro. 
COMPBIAS   439   444  6     Poly-His. 
CONFLICT   27    28        Missing (in Ref. 1; AAA59965). 
CONFLICT   87    88        GP -> A (in Ref. 1; AAA59965 and 4; CAA79158). 
Sequence information
Length: 451 AA [This is the length of the unprocessed precursor] Molecular weight: 45496 Da [This is the MW of the unprocessed precursor] CRC64: 563217BD6A3D00CD [This is a checksum on the sequence]
        10         20         30         40         50         60 
MATTAQYLPR GPGGGAGGTG PLMHPDAAAA AAAAAAAERL HAGAAYREVQ KLMHHEWLGA 

        70         80         90        100        110        120 
GAGHPVGLAH PQWLPTGGGG GGDWAGGPHL EHGKAGGGGT GRADDGGGGG GFHARLVHQG 

       130        140        150        160        170        180 
AAHAGAAWAQ GSTAHHLGPA MSPSPGASGG HQPQPLGLYA QAAYPGGGGG GLAGMLAAGG 

       190        200        210        220        230        240 
GGAGPGLHHA LHEDGHEAQL EPSPPPHLGA HGHAHGHAHA GGLHAAAAHL HPGAGGGGSS 

       250        260        270        280        290        300 
VGEHSDEDAP SSDDLEQFAK QFKQRRIKLG FTQADVGLAL GTLYGNVFSQ TTICRFEALQ 

       310        320        330        340        350        360 
LSFKNMCKLK PLLNKWLEET DSSSGSPTNL DKIAAQGRKR KKRTSIEVGV KGALESHFLK 

       370        380        390        400        410        420 
CPKPSAHEIT GLADSLQLEK EVVRVWFCNR RQKEKRMTPA AGAGHPPMDD VYAPGELGPG 

       430        440        450 
GGGASPPSAP PPPPPAALHH HHHHTLPGSV Q 

Q03052 in FASTA format

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