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UniProtKB/Swiss-Prot entry Q02241


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name KIF23_HUMAN
Primary accession number Q02241
Secondary accession number Q8WVP0
Integrated into Swiss-Prot on July 1, 1993
Sequence was last modified on November 28, 2006 (Sequence version 3)
Annotations were last modified on    July 1, 2008 (Entry version 86)
Name and origin of the protein
Protein name Kinesin-like protein KIF23
Synonyms Mitotic kinesin-like protein 1
Kinesin-like protein 5
Gene name
Name: KIF23
Synonyms: KNSL5, MKLP1
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
DOI=10.1038/359543a0; PubMed=1406973 [NCBI, ExPASy, EBI, Israel, Japan]
Nislow C., Lombillo V.A., Kuriyama R., McIntosh J.R.;
"A plus-end-directed motor enzyme that moves antiparallel microtubules in vitro localizes to the interzone of mitotic spindles.";
Nature 359:543-547(1992).
[2]
SEQUENCE REVISION.
Gryka M.A.;
Submitted (JAN-2000) to the EMBL/GenBank/DDBJ databases.
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), AND NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 5-960 (ISOFORM 1).
TISSUE=Lymph, and Uterus;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[4]
INTERACTION WITH PRC1.
DOI=10.1038/sj.emboj.7600347; PubMed=15297875 [NCBI, ExPASy, EBI, Israel, Japan]
Kurasawa Y., Earnshaw W.C., Mochizuki Y., Dohmae N., Todokoro K.;
"Essential roles of KIF4 and its binding partner PRC1 in organized central spindle midzone formation.";
EMBO J. 23:3237-3248(2004).
[5]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-684, AND MASS SPECTROMETRY.
TISSUE=Epithelium;
DOI=10.1073/pnas.0404720101; PubMed=15302935 [NCBI, ExPASy, EBI, Israel, Japan]
Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J., Li J., Cohn M.A., Cantley L.C., Gygi S.P.;
"Large-scale characterization of HeLa cell nuclear phosphoproteins.";
Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004).
[6]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-29, AND MASS SPECTROMETRY.
DOI=10.1038/nbt1046; PubMed=15592455 [NCBI, ExPASy, EBI, Israel, Japan]
Rush J., Moritz A., Lee K.A., Guo A., Goss V.L., Spek E.J., Zhang H., Zha X.-M., Polakiewicz R.D., Comb M.J.;
"Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.";
Nat. Biotechnol. 23:94-101(2005).
[7]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-155; SER-814; SER-867 AND SER-902, AND MASS SPECTROMETRY.
TISSUE=Epithelium;
DOI=10.1016/j.cell.2006.09.026; PubMed=17081983 [NCBI, ExPASy, EBI, Israel, Japan]
Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.;
"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.";
Cell 127:635-648(2006).
[8]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-450 AND THR-738, AND MASS SPECTROMETRY.
TISSUE=Epithelium;
DOI=10.1038/nbt1240; PubMed=16964243 [NCBI, ExPASy, EBI, Israel, Japan]
Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.;
"A probability-based approach for high-throughput protein phosphorylation analysis and site localization.";
Nat. Biotechnol. 24:1285-1292(2006).
[9]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-160; SER-682; SER-684; SER-911 AND SER-912, AND MASS SPECTROMETRY.
TISSUE=Epithelium;
DOI=10.1073/pnas.0507066103; PubMed=16565220 [NCBI, ExPASy, EBI, Israel, Japan]
Nousiainen M., Sillje H.H.W., Sauer G., Nigg E.A., Koerner R.;
"Phosphoproteome analysis of the human mitotic spindle.";
Proc. Natl. Acad. Sci. U.S.A. 103:5391-5396(2006).
[10]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-686, AND MASS SPECTROMETRY.
TISSUE=Epithelium;
DOI=10.1021/pr070152u; PubMed=17924679 [NCBI, ExPASy, EBI, Israel, Japan]
Yu L.-R., Zhu Z., Chan K.C., Issaq H.J., Dimitrov D.S., Veenstra T.D.;
"Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra.";
J. Proteome Res. 6:4150-4162(2007).
[11]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-682; SER-684; SER-686; SER-911; SER-912 AND THR-913, AND MASS SPECTROMETRY.
DOI=10.1021/pr0705441; PubMed=18220336 [NCBI, ExPASy, EBI, Israel, Japan]
Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III;
"Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.";
J. Proteome Res. 7:1346-1351(2008).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
X67155; CAA47628.2; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC017705; AAH17705.2; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC051826; AAH51826.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR S28262; S28262.
RefSeq NP_004847.2; -.
NP_612565.1; -.
UniGene Hs.270845
3D structure databases
HSSP P17119; 1F9W. [HSSP ENTRY / PDB]
ModBase Q02241.
Protein-protein interaction databases
IntAct Q02241; -.
PTM databases
PhosphoSite Q02241; -.
Enzyme and pathway databases
Reactome REACT_152; Cell Cycle, Mitotic.
Organism-specific databases
H-InvDB HIX0012389; -.
HGNC HGNC:6392; KIF23.
GeneLynx KIF23; Homo sapiens.
GenAtlas KIF23.
MIM 605064; gene. [NCBI / EBI]
PharmGKB PA30181; -.
GeneCards Q02241.
Gene expression databases
ArrayExpress Q02241; -.
CleanEx HS_KIF23; -.
GermOnline ENSG00000137807; Homo sapiens.
Ontologies
GO
GO:0005871; Cellular component: kinesin complex (traceable author statement from ProtInc).
GO:0005654; Cellular component: nucleoplasm (inferred from experiment from Reactome).
GO:0005819; Cellular component: spindle (traceable author statement from ProtInc).
GO:0003777; Molecular function: microtubule motor activity (traceable author statement from ProtInc).
GO:0005515; Molecular function: protein binding (inferred from physical interaction from IntAct).
GO:0000022; Biological process: mitotic spindle elongation (traceable author statement from ProtInc).
QuickGo view.
Family and domain databases
InterPro IPR001752; Kinesin_motor.
Graphical view of domain structure.
Pfam PF00225; Kinesin; 1.
Pfam graphical view of domain structure.
PRINTS PR00380; KINESINHEAVY.
SMART SM00129; KISc; 1.
SMART graphical view of domain structure.
PROSITE PS00411; KINESIN_MOTOR_DOMAIN1; 1.
PS50067; KINESIN_MOTOR_DOMAIN2; 1.
PROSITE graphical view of domain structure (profiles).
BLOCKS Q02241.
Genome annotation databases
Ensembl ENSG00000137807; Homo sapiens. [Contig view]
GeneID 9493; -.
KEGG hsa:9493; -.
NMPDR fig|9606.3.peg.10905; -.
Phylogenomic databases
HOVERGEN Q02241; -.
Other
LinkHub Q02241; -.
SOURCE KIF23; Homo sapiens.
ProtoNet Q02241.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Alternative splicing; ATP-binding; Cell cycle; Cell division; Coiled coil; Microtubule; Mitosis; Motor protein; Nucleotide-binding; Nucleus; Phosphoprotein.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   960  960     Kinesin-like protein KIF23. PRO_0000125434
DOMAIN   1   352  352     Kinesin-motor. 
NP_BIND   112   119  8     ATP (By similarity). 
COILED   535   620  86     Potential. 
MOTIF   7    11  5     Nuclear localization signal (Potential). 
MOD_RES   29    29        Phosphotyrosine. 
MOD_RES   155   155        Phosphoserine. 
MOD_RES   160   160        Phosphoserine. 
MOD_RES   450   450        Phosphothreonine. 
MOD_RES   682   682        Phosphoserine. 
MOD_RES   684   684        Phosphoserine. 
MOD_RES   686   686        Phosphoserine. 
MOD_RES   738   738        Phosphothreonine. 
MOD_RES   814   814        Phosphoserine. 
MOD_RES   867   867        Phosphoserine. 
MOD_RES   902   902        Phosphoserine. 
MOD_RES   911   911        Phosphoserine. 
MOD_RES   912   912        Phosphoserine. 
MOD_RES   913   913        Phosphothreonine. 
VAR_SEQ   690   793        Missing (in isoform 2). VSP_021801
Sequence information
Length: 960 AA [This is the length of the unprocessed precursor] Molecular weight: 110059 Da [This is the MW of the unprocessed precursor] CRC64: B2AA784D2D236A90 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MKSARAKTPR KPTVKKGSQT NLKDPVGVYC RVRPLGFPDQ ECCIEVINNT TVQLHTPEGY 

        70         80         90        100        110        120 
RLNRNGDYKE TQYSFKQVFG THTTQKELFD VVANPLVNDL IHGKNGLLFT YGVTGSGKTH 

       130        140        150        160        170        180 
TMTGSPGEGG LLPRCLDMIF NSIGSFQAKR YVFKSNDRNS MDIQCEVDAL LERQKREAMP 

       190        200        210        220        230        240 
NPKTSSSKRQ VDPEFADMIT VQEFCKAEEV DEDSVYGVFV SYIEIYNNYI YDLLEEVPFD 

       250        260        270        280        290        300 
PIKPKPPQSK LLREDKNHNM YVAGCTEVEV KSTEEAFEVF WRGQKKRRIA NTHLNRESSR 

       310        320        330        340        350        360 
SHSVFNIKLV QAPLDADGDN VLQEKEQITI SQLSLVDLAG SERTNRTRAE GNRLREAGNI 

       370        380        390        400        410        420 
NQSLMTLRTC MDVLRENQMY GTNKMVPYRD SKLTHLFKNY FDGEGKVRMI VCVNPKAEDY 

       430        440        450        460        470        480 
EENLQVMRFA EVTQEVEVAR PVDKAICGLT PGRRYRNQPR GPVGNEPLVT DVVLQSFPPL 

       490        500        510        520        530        540 
PSCEILDIND EQTLPRLIEA LEKRHNLRQM MIDEFNKQSN AFKALLQEFD NAVLSKENHM 

       550        560        570        580        590        600 
QGKLNEKEKM ISGQKLEIER LEKKNKTLEY KIEILEKTTT IYEEDKRNLQ QELETQNQKL 

       610        620        630        640        650        660 
QRQFSDKRRL EARLQGMVTE TTMKWEKECE RRVAAKQLEM QNKLWVKDEK LKQLKAIVTE 

       670        680        690        700        710        720 
PKTEKPERPS RERDREKVTQ RSVSPSPVPL SSNYIAQISN GQQLMSQPQL HRRSNSCSSI 

       730        740        750        760        770        780 
SVASCISEWE QKIPTYNTPL KVTSIARRRQ QEPGQSKTCI VSDRRRGMYW TEGREVVPTF 

       790        800        810        820        830        840 
RNEIEIEEDH CGRLLFQPDQ NAPPIRLRHR RSRSAGDRWV DHKPASNMQT ETVMQPHVPH 

       850        860        870        880        890        900 
AITVSVANEK ALAKCEKYML THQELASDGE IETKLIKGDI YKTRGGGQSV QFTDIETLKQ 

       910        920        930        940        950        960 
ESPNGSRKRR SSTVAPAQPD GAESEWTDVE TRCSVAVEMR AGSQLGPGYQ HHAQPKRKKP 

Q02241 in FASTA format

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