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UniProtKB/Swiss-Prot entry Q02195

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name FGF7_RAT
Primary accession number Q02195
Secondary accession numbers None
Integrated into Swiss-Prot on July 1, 1993
Sequence was last modified on July 1, 1993 (Sequence version 1)
Annotations were last modified on    November 25, 2008 (Entry version 73)
Name and origin of the protein
Protein name Keratinocyte growth factor [Precursor]
Synonyms KGF
Fibroblast growth factor 7
FGF-7
Heparin-binding growth factor 7
HBGF-7
Gene name
Name: Fgf7
Synonyms: Fgf-7, Kgf
From
Rattus norvegicus (Rat) [TaxID: 10116] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus.
Protein existence 1: Evidence at protein level;
References
[1]
 NUCLEOTIDE SEQUENCE [MRNA].
PubMed=1869483 [NCBI, ExPASy, EBI, Israel, Japan]
Yan G., Nikolaropoulos S., Wang F., McKeehan W.L.;
"Sequence of rat keratinocyte growth factor (heparin-binding growth factor type 7).";
In Vitro Cell. Dev. Biol. 27A:437-438(1991).
[2]
 X-RAY CRYSTALLOGRAPHY (3.1 ANGSTROMS) OF 55-294.
Ye S., Luo Y., Lu W., Jones R.B., Linhardt R.J., Kan M., McKeehan W.L., Pelletier H.;
"The crystal structures of rat fibroblast growth factor 7 and rat / human fibroblast growth factor 1 chimera.";
Submitted (JUN-1999) to the PDB data bank.
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
X56551; CAA39892.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR S26049; S26049.
RefSeq NP_071518.1; -.
UniGene Rn.98842
3D structure databases
PDB
1QQK; X-ray; 3.10 A; A/B=55-194.[ExPASy / RCSB / EBI]
1QQL; X-ray; 2.30 A; A=55-171.[ExPASy / RCSB / EBI]
Detailed list of linked structures.
PDBsum 1QQK; -.
1QQL; -.
ModBase Q02195.
Organism-specific databases
RGD 61805; Fgf7.
Gene expression databases
ArrayExpress Q02195; -.
GermOnline ENSRNOG00000009425; Rattus norvegicus.
Ontologies
GO
GO:0008083; Molecular function: growth factor activity (inferred from electronic annotation from InterPro).
QuickGo view.
Family and domain databases
InterPro IPR002209; GF_heparin_bd.
IPR002348; IL1_HBGF.
Graphical view of domain structure.
PANTHER PTHR11486; IL1_HBGF; 1.
Pfam PF00167; FGF; 1.
Pfam graphical view of domain structure.
PRINTS PR00263; HBGFFGF.
PR00262; IL1HBGF.
ProDom PD000831; IL1_HBGF; 1.
[Domain structure / List of seq. sharing at least 1 domain]
SMART SM00442; FGF; 1.
SMART graphical view of domain structure.
PROSITE PS00247; HBGF_FGF; 1.
ProtoNet Q02195.
Genome annotation databases
Ensembl ENSRNOG00000009425; Rattus norvegicus. [Contig view]
GeneID 29348; -.
KEGG rno:29348; -.
Phylogenomic databases
HOVERGEN Q02195; -.
Other
NextBio 608848; -.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
3D-structure; Glycoprotein; Growth factor; Mitogen; Signal.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
SIGNAL   1    31  31     By similarity. 
CHAIN   32   194  163     Keratinocyte growth factor. PRO_0000008968
CARBOHYD   45    45        N-linked (GlcNAc...) (Potential). 
CARBOHYD   149   149        N-linked (GlcNAc...) (Potential). 
STRAND   64    67  4      
TURN   72    74  3      
STRAND   75    79  5      
STRAND   85    90  6      
STRAND   98   104  7      
STRAND   107   112  6      
TURN   113   115  3      
HELIX   135   137  3      
STRAND   138   143  6      
STRAND   145   147  3      
STRAND   149   154  6      
TURN   155   162  8      
HELIX   176   178  3      
STRAND   188   191  4      
Sequence information
Length: 194 AA [This is the length of the unprocessed precursor] Molecular weight: 22268 Da [This is the MW of the unprocessed precursor] CRC64: 5242CDAC305CC8C1 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MRKWILTRIL PTPLYRPCFH LVCLVGTISL ACNDMSPEQT ATSVNCSSPE RHTRSYDYME 

        70         80         90        100        110        120 
GGDIRVRRLF CRTQWYLRID KRGKVKGTQE MRNSYNIMEI MTVAVGIVAI KGVESEYYLA 

       130        140        150        160        170        180 
MNKQGELYAK KECNEDCNFK ELILENHYNT SASAKWTHSG GEMFVALNQK GLPVKGKKTK 

       190 
KEQKTAHFLP MAIT
Q02195 in FASTA format

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