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UniProtKB/Swiss-Prot entry Q00958


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name LFY_ARATH
Primary accession number Q00958
Secondary accession numbers Q8LSH2 Q8LSH3
Integrated into Swiss-Prot on April 1, 1993
Sequence was last modified on April 1, 1993 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 65)
Name and origin of the protein
Protein name Protein LEAFY
Synonyms None
Gene name
Name: LFY
OrderedLocusNames: At5g61850
ORFNames: MAC9.18
From
Arabidopsis thaliana (Mouse-ear cress) [TaxID: 3702] 
Taxonomy Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliophyta; eudicotyledons; core eudicotyledons; rosids; eurosids II; Brassicales; Brassicaceae; Arabidopsis.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
DOI=10.1016/0092-8674(92)90295-N; PubMed=1350515 [NCBI, ExPASy, EBI, Israel, Japan]
Weigel D., Alvarez J., Smyth D.R., Yanofsky M.F., Meyerowitz E.M.;
"LEAFY controls floral meristem identity in Arabidopsis.";
Cell 69:843-859(1992).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANTS.
STRAIN=cv. Bla-1, cv. Bretagny, cv. Bs-1, cv. Bu-0, cv. Bu-2, cv. Chi-1, cv. Co-1, cv. Columbia, cv. Cvi-0, cv. Gr-3, cv. Ita-0, cv. Jl-1, cv. Kas-1, cv. Kent, cv. Landsberg erecta, cv. Li-3, cv. Li-8, cv. Lisse, and cv. Wassilewskija;
PubMed=11973317 [NCBI, ExPASy, EBI, Israel, Japan]
Olsen K.M., Womack A., Garrett A.R., Suddith J.I., Purugganan M.D.;
"Contrasting evolutionary forces in the Arabidopsis thaliana floral developmental pathway.";
Genetics 160:1641-1650(2002).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=cv. Columbia;
DOI=10.1093/dnares/5.1.41; PubMed=9628582 [NCBI, ExPASy, EBI, Israel, Japan]
Sato S., Kaneko T., Kotani H., Nakamura Y., Asamizu E., Miyajima N., Tabata S.;
"Structural analysis of Arabidopsis thaliana chromosome 5. IV. Sequence features of the regions of 1,456,315 bp covered by nineteen physically assigned P1 and TAC clones.";
DNA Res. 5:41-54(1998).
[4]
FUNCTION.
Bowman J.L., Alvarez J., Weigel D., Meyerowitz E.M., Smyth D.R.;
"Control of flower development in Arabidopsis thaliana by APETALA1 and interacting genes.";
Development 119:721-743(1993).
[5]
FUNCTION.
PubMed=8565821 [NCBI, ExPASy, EBI, Israel, Japan]
Krizek B.A., Meyerowitz E.M.;
"The Arabidopsis homeotic genes APETALA3 and PISTILLATA are sufficient to provide the B class organ identity function.";
Development 122:11-22(1996).
[6]
FUNCTION.
DOI=10.1038/26903; PubMed=9783581 [NCBI, ExPASy, EBI, Israel, Japan]
Parcy F., Nilsson O., Busch M.A., Lee I., Weigel D.;
"A genetic framework for floral patterning.";
Nature 395:561-566(1998).
Comments
  • FUNCTION: Probable transcription factor that promotes early floral meristem identity in synergy with APETALA1. Is required subsequently for the transition of an inflorescence meristem into a floral meristem, by an immediate upstream regulation of the ABC classes of floral homeotic genes. Activates directly APETALA1, CAULIFLOWER and AGAMOUS, and indirectly APETALA3 and PISTILLATA with the cooperation of UFO.
  • INTERACTION:
    Q39090:UFO; NbExp=3; IntAct=EBI-1644366, EBI-590758;
  • SUBCELLULAR LOCATION: Nucleus (Probable).
  • TISSUE SPECIFICITY: Expressed uniformly throughout the young floral primordia.
  • DEVELOPMENTAL STAGE: Expressed at an early stage of floral initiation.
  • INDUCTION: Positively regulated by CAULIFLOWER and APETALA1. Down-regulated by TFL1.
  • MISCELLANEOUS: Mutations in the LEAFY gene result in the complete transformation of the first few flowers into leaves with associated shoots.
  • SIMILARITY: Belongs to the FLO/LFY family.
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
M91208; AAA32826.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF466787; AAM27927.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF466788; AAM27928.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF466789; AAM27929.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF466790; AAM27930.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF466791; AAM27931.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF466792; AAM27932.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF466793; AAM27933.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF466794; AAM27934.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF466795; AAM27935.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF466796; AAM27936.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF466797; AAM27937.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF466798; AAM27938.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF466799; AAM27939.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF466800; AAM27940.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF466801; AAM27941.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AB010069; BAB10085.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR A38104; A38104.
B38104; B38104.
C38104; C38104.
3D structure databases
ModBase Q00958.
Protein-protein interaction databases
IntAct Q00958; -.
Organism-specific databases
TAIR At5g61850; -.
Gene expression databases
ArrayExpress Q00958; -.
Ontologies
GO
GO:0005515; Molecular function: protein binding (inferred from physical interaction from IntAct).
QuickGo view.
Family and domain databases
InterPro IPR002910; FLO_LFY.
Graphical view of domain structure.
Pfam PF01698; FLO_LFY; 1.
Pfam graphical view of domain structure.
BLOCKS Q00958.
Genome annotation databases
GenomeReviews BA000015_GR; AT5G61850.
Other
ProtoNet Q00958.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Activator; Coiled coil; Complete proteome; Developmental protein; Differentiation; DNA-binding; Flowering; Nucleus; Polymorphism; Transcription; Transcription regulation.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   424  424     Protein LEAFY. PRO_0000129147
COILED   108   133  26     Potential. 
COMPBIAS   23    29  7     Poly-Pro. 
COMPBIAS   114   130  17     Arg/Glu-rich. 
COMPBIAS   208   220  13     Asp/Glu-rich (acidic). 
VARIANT   8     8  1     S -> R (in strain: cv. Jl-1). 
VARIANT   78    78  1     G -> D (in strain: cv. Ita-0). 
Sequence information
Length: 424 AA [This is the length of the unprocessed precursor] Molecular weight: 47100 Da [This is the MW of the unprocessed precursor] CRC64: 246FD1263C6638AA [This is a checksum on the sequence]
        10         20         30         40         50         60 
MDPEGFTSGL FRWNPTRALV QAPPPVPPPL QQQPVTPQTA AFGMRLGGLE GLFGPYGIRF 

        70         80         90        100        110        120 
YTAAKIAELG FTASTLVGMK DEELEEMMNS LSHIFRWELL VGERYGIKAA VRAERRRLQE 

       130        140        150        160        170        180 
EEEEESSRRR HLLLSAAGDS GTHHALDALS QEDDWTGLSE EPVQQQDQTD AAGNNGGGGS 

       190        200        210        220        230        240 
GYWDAGQGKM KKQQQQRRRK KPMLTSVETD EDVNEGEDDD GMDNGNGGSG LGTERQREHP 

       250        260        270        280        290        300 
FIVTEPGEVA RGKKNGLDYL FHLYEQCREF LLQVQTIAKD RGEKCPTKVT NQVFRYAKKS 

       310        320        330        340        350        360 
GASYINKPKM RHYVHCYALH CLDEEASNAL RRAFKERGEN VGSWRQACYK PLVNIACRHG 

       370        380        390        400        410        420 
WDIDAVFNAH PRLSIWYVPT KLRQLCHLER NNAVAAAAAL VGGISCTGSS TSGRGGCGGD 


DLRF 

Q00958 in FASTA format

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View entry in raw text format (no links)
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