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[1]
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NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS ALPHA AND BETA).
TISSUE=Testis;
PubMed=9001252 [NCBI, ExPASy, EBI, Israel, Japan]
Mackey Z.B.,
Ramos W.,
Levin D.S.,
Walter C.A.,
McCarrey J.R.,
Tomkinson A.E.;
"An alternative splicing event which occurs in mouse pachytene spermatocytes generates a form of DNA ligase III with distinct biochemical properties that may function in meiotic recombination.";
Mol. Cell. Biol. 17:989-998(1997).
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[2]
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PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-210, AND MASS SPECTROMETRY.
TISSUE=Liver;
DOI=10.1073/pnas.0609836104; PubMed=17242355 [NCBI, ExPASy, EBI, Israel, Japan]
Villen J.,
Beausoleil S.A.,
Gerber S.A.,
Gygi S.P.;
"Large-scale phosphorylation analysis of mouse liver.";
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
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- FUNCTION: The alpha isoform interacts with DNA-repair protein XRCC1 and can correct defective DNA strand-break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents. The beta isoform does not interact with XRCC1 and may be specifically involved in the completion of homologous recombination events that occur during meiotic prophase.
- CATALYTIC ACTIVITY: ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).
- SUBCELLULAR LOCATION: Nucleus.
- ALTERNATIVE PRODUCTS:
2 named isoforms [FASTA] produced by alternative splicing.
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| Name | Beta |
| Isoform ID | P97386-2 |
| Features which should be applied to build the isoform sequence: VSP_001303. |
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- TISSUE SPECIFICITY: The alpha isoform is expressed in all tissues, while the beta isoform is expressed only in the testis.
- DEVELOPMENTAL STAGE: During male germ cell differentiation, expression of the beta isoform begins in the later stages of meiotic prophase and ends in the round spermatid stage.
- SIMILARITY: Belongs to the ATP-dependent DNA ligase family.
- SIMILARITY: Contains 1 BRCT domain.
- SIMILARITY: Contains 1 PARP-type zinc finger.
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Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms.
Distributed under the Creative Commons Attribution-NoDerivs License.
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| Length: 1015 AA [This is the length of the unprocessed precursor] |
Molecular weight: 113018 Da [This is the MW of the unprocessed precursor] |
CRC64: DE96B81CD9C5FC36 [This is a checksum on the sequence] |
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10 20 30 40 50 60
MTLAFKILFP RNLCALGRKE LCLFPEQNRW AAISQFSQWS ETNLLGGCCL LQRRKPVLAL
70 80 90 100 110 120
QRGHLRPRAT HLTFWPGSHV GLCTGPCAMA EQRFCVDYAK RGTAGCKKCK EKIVKGVCRI
130 140 150 160 170 180
GKVVPNPFSE SGGDMKEWYH IKCMFEKLER ARATTKKIED LTELEGWEEL EDNEKEQISQ
190 200 210 220 230 240
HIADLSSKAA ATPKKKAAVQ AKLTTTGQVT SPVKGASFIT STNPRKFSGF SAAKPNNSEQ
250 260 270 280 290 300
APSSPAPGTS LSASKCDPKH KDCLLREFRK LCAMVAENPS YNTKTQIIHD FLQKGSTGST
310 320 330 340 350 360
GDGFHGDVYL TVKLLLPGVI KSVYNLNDKQ IVKLFSRIFN CNPDDMARDL EQGDVSETIR
370 380 390 400 410 420
IFFEQSKSFP PAAKSLLTIQ EVDAFLLHLS KLTKEDEQQQ ALQDIASRCT ANDLKCIRLI
430 440 450 460 470 480
KHDLKMNSGA KHVLDALDPN AYEAFKASRN LQDVVERVLH NEQEVEKDPG RRRALRVQAS
490 500 510 520 530 540
LMTPVQPMLA EACKSIEYAM KKCPNGMFSE IKYDGERVQV HKKGDHFSYF SRSLKPVLPH
550 560 570 580 590 600
KVAHFKDYIP KAFPGGQSMI LDSEVLLIDN NTGKPLPFGT LGVHKKAAFQ DANLCLFVFD
610 620 630 640 650 660
CIYFNDVSLM DRPLCERRKF LHDNMVEIRN RIMFSEMKQV TKASDLADMI NRVIREGLEG
670 680 690 700 710 720
LVLKDVKGTY EPGKRHWLKV KKDYLNEGAM ADTADLVVLG VFLIGQGSKG GMMSIFLMGC
730 740 750 760 770 780
YDPDSQKWCT VTKCAGGHDD ATLARLQKEL VMVKISKDPS KIPSWLKINK IYYPDFIVPD
790 800 810 820 830 840
PKKAAVWEIT GAEFSRSEAH TADGISIRFP RCTRIRDDKD WKSATNLPQL KELYQLSKDK
850 860 870 880 890 900
ADFAVVAGDE ASPTTGGSSG ENEGTAGSAG PCKGPPSKSS ASAKTTEQKL NSPSSRGGIK
910 920 930 940 950 960
PIPKHSPMKP GEKLAVKSSP VKVGMKRKAT DETPCLKKVL LDVFTGVRLY LPPSTPDFKR
970 980 990 1000 1010
LKRYFVAFDG DLVQEFDMGS ATHVLGNREK NTDAQLVSSE WIWACIRKRR LIAPC
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P97386 in FASTA format |
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