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UniProtKB/Swiss-Prot entry P96318

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name IDH_CALNO
Primary accession number P96318
Secondary accession numbers None
Integrated into Swiss-Prot on August 29, 2001
Sequence was last modified on May 1, 2000 (Sequence version 2)
Annotations were last modified on    July 22, 2008 (Entry version 51)
Name and origin of the protein
Protein name Isocitrate dehydrogenase [NADP]
Synonyms IDH
EC 1.1.1.42
Oxalosuccinate decarboxylase
NADP(+)-specific ICDH
IDP
Gene name
Name: icd
From
Caldococcus noboribetus [TaxID: 57174] 
Taxonomy Archaea; Crenarchaeota; Thermoprotei; Desulfurococcales; Caldococcus.
Protein existence 1: Evidence at protein level;
References
[1]
 NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=NC12;
DOI=10.1006/abbi.1996.0534; PubMed=8951037 [NCBI, ExPASy, EBI, Israel, Japan]
Aoshima M., Yamagishi A., Oshima T.;
"Eubacteria-type isocitrate dehydrogenase from an Archaeon: cloning, sequencing, and expression of a gene encoding isocitrate dehydrogenase from a hyperthermophilic archaebacterium Caldococcus noboribetus.";
Arch. Biochem. Biophys. 336:77-85(1996).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
D86855; BAA13177.2; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR T44658; T44658.
3D structure databases
HSSP P39126; 1HQS. [HSSP ENTRY / PDB]
ModBase P96318.
Family and domain databases
InterPro IPR004439; IsoCit_DHase_NADP_prok.
IPR001804; IsoCit_IM_DHase.
Graphical view of domain structure.
Gene3D G3DSA:3.40.718.10; IDH_IMDH; 1.
PANTHER PTHR11835; IDH_IMDH_dimeric; 1.
PTHR11835:SF1; NADP_IDH_prok; 1.
Pfam PF00180; Iso_dh; 1.
Pfam graphical view of domain structure.
TIGRFAMs TIGR00183; prok_nadp_idh; 1.
PROSITE PS00470; IDH_IMDH; 1.
BLOCKS P96318.
Other
ProtoNet P96318.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Glyoxylate bypass; Magnesium; Manganese; Metal-binding; NADP; Oxidoreductase; Phosphoprotein; Tricarboxylic acid cycle.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   429  429     Isocitrate dehydrogenase [NADP]. PRO_0000083573
NP_BIND   340   346  7     NADP (By similarity). 
METAL   308   308        Magnesium or manganese (By similarity). 
BINDING   108   108        NADP (By similarity). 
BINDING   117   117        Substrate (By similarity). 
BINDING   119   119        Substrate (By similarity). 
BINDING   123   123        Substrate (By similarity). 
BINDING   133   133        Substrate (By similarity). 
BINDING   156   156        Substrate (By similarity). 
BINDING   353   353        NADP; via amide nitrogen and carbonyl oxygen (By similarity). 
BINDING   393   393        NADP (By similarity). 
BINDING   397   397        NADP (By similarity). 
SITE   163   163  1     Critical for catalysis (By similarity). 
SITE   230   230  1     Critical for catalysis (By similarity). 
MOD_RES   117   117        Phosphoserine (By similarity). 
Sequence information
Length: 429 AA [This is the length of the unprocessed precursor] Molecular weight: 47620 Da [This is the MW of the unprocessed precursor] CRC64: F06A559FCAA1C42B [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MVSHPCTADE AKPPSEGQLA RFENGKLIVP DNLIVAYFKG DGIGPEIVES AKKVLDAAVD 

        70         80         90        100        110        120 
KAYGGTRRIV WWEVTAGEEA QKECGSLLPD GTLQAFKLAR VNLKGPLTTP VGGGFRSLNV 

       130        140        150        160        170        180 
TLRMVLDLYS NVRPVKWYGQ PTPHCHPENI DWVIFRENTE DVYAGIEWPF DSPEAQKIRD 

       190        200        210        220        230        240 
FLKKEFGIEL TPDTGIGIKP ISKWRTQRHV RRAMEWAIRN GYKHVTIMHK GNIMKYTEGA 

       250        260        270        280        290        300 
FRQWAYDLIL SEFRDYVVTE EEVNTKYGGK APEGKIIVND RIADNMLQQI ITRPGEYNVI 

       310        320        330        340        350        360 
VTPNLNGDYI SDEANALVGG IGMAAGLDMG DGIAVAEPVH GSAPKYAGKN VINPTAEILS 

       370        380        390        400        410        420 
GMYLLSDFVG WPEVKLLVEY AVKQAIAHKQ VTYDLAREMG GVTPISTTEY TDVLVDYIRH 


ADLKALKGQ
P96318 in FASTA format

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