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UniProtKB/Swiss-Prot entry P82140


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name DLP2_ORNAN
Primary accession number P82140
Secondary accession numbers None
Integrated into Swiss-Prot on May 30, 2000
Sequence was last modified on May 1, 2000 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 45)
Name and origin of the protein
Protein name Defensin-like peptide 2/4
Synonym DLP-2/DLP-4
Gene name None
From
Ornithorhynchus anatinus (Duckbill platypus) [TaxID: 9258] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Monotremata; Ornithorhynchidae; Ornithorhynchus.
Protein existence 1: Evidence at protein level;
References
[1]
PROTEIN SEQUENCE, FUNCTION, SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
TISSUE=Venom, and Venom gland;
DOI=10.1042/0264-6021:3410785; PubMed=10417345 [NCBI, ExPASy, EBI, Israel, Japan]
Torres A.M., Wang X., Fletcher J.I., Alewood D., Alewood P.F., Smith R., Simpson R.J., Nicholson G.M., Sutherland S.K., Gallagher C.H., King G.F., Kuchel P.W.;
"Solution structure of a defensin-like peptide from platypus venom.";
Biochem. J. 341:785-794(1999).
[2]
PROTEIN SEQUENCE, AND STRUCTURE BY NMR.
TISSUE=Venom;
DOI=10.1042/0264-6021:3480649; PubMed=10839998 [NCBI, ExPASy, EBI, Israel, Japan]
Torres A.M., de Plater G.M., Doverskog M., Birinyi-Strachan L.C., Nicholson G.M., Gallagher C.H., Kuchel P.W.;
"Defensin-like peptide-2 from platypus venom: member of a class of peptides with a distinct structural fold.";
Biochem. J. 348:649-656(2000).
[3]
D-AMINO ACID AT MET-2, TISSUE SPECIFICITY, AND STRUCTURE BY NMR.
DOI=10.1042/BJ20050900; PubMed=16033333 [NCBI, ExPASy, EBI, Israel, Japan]
Torres A.M., Tsampazi C., Geraghty D.P., Bansal P.S., Alewood P.F., Kuchel P.W.;
"D-amino acid residue in a defensin-like peptide from platypus venom: effect on structure and chromatographic properties.";
Biochem. J. 391:215-220(2005).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
3D structure databases
PDB
1D6B; NMR; -; A=1-42.[ExPASy / RCSB / EBI]
1ZUE; NMR; -; A=1-42.[ExPASy / RCSB / EBI]
1ZUF; NMR; -; A=1-42.[ExPASy / RCSB / EBI]
Detailed list of linked structures.
PDBsum 1D6B; -.
1ZUE; -.
1ZUF; -.
ModBase P82140.
Ontologies
GO
GO:0005576; Cellular component: extracellular region (inferred from direct assay from UniProtKB).
GO:0009405; Biological process: pathogenesis (inferred from expression pattern from UniProtKB).
QuickGo view.
Family and domain databases
InterPro IPR012553; Defensin_3.
Graphical view of domain structure.
Pfam PF08131; Defensin_3; 1.
Pfam graphical view of domain structure.
BLOCKS P82140.
Genome annotation databases
Ensembl ENSOANG00000001779; Ornithorhynchus anatinus. [Contig view]
Phylogenomic databases
HOVERGEN P82140; -.
Other
ProtoNet P82140.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
3D-structure; D-amino acid; Direct protein sequencing; Secreted; Toxin.
Features
SEVIEWER logo Feature table viewer
KeyFrom  To Length Description FTId
CHAIN   1   42  42     Defensin-like peptide 2/4. PRO_0000079933
MOD_RES   2    2        D-methionine; in form DLP-2. 
DISULFID   9   39         
DISULFID   16   32         
DISULFID   24   40         
HELIX   9   12  4      
STRAND   15   18  4      
STRAND   37   40  4      
Sequence information
Length: 42 AA [This is the length of the unprocessed precursor] Molecular weight: 5115 Da [This is the MW of the unprocessed precursor] CRC64: A1A26FB9D821F50C [This is a checksum on the sequence]
        10         20         30         40 
IMFFEMQACW SHSGVCRDKS ERNCKPMAWT YCENRNQKCC EY 

P82140 in FASTA format

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Tools Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
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