[1]	NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND RNA EDITING. TISSUE=Tuber; DOI=10.1007/BF00280184; PubMed=8041359 [NCBI, ExPASy, EBI, Israel, Japan] Gabler L., Herz U., Liddell A., Leaver C.J., Schroeder W., Brennicke A., Grohmann L.; "The 42.5 kDa subunit of the NADH: ubiquinone oxidoreductase (complex I) in higher plants is encoded by the mitochondrial nad7 gene."; Mol. Gen. Genet. 244:33-40(1994).
[2]	PROTEIN SEQUENCE OF 2-37. STRAIN=cv. Bintje; TISSUE=Tuber; PubMed=8294484 [NCBI, ExPASy, EBI, Israel, Japan] Herz U., Schroeder W., Liddell A., Leaver C.J., Brennicke A., Grohmann L.; "Purification of the NADH:ubiquinone oxidoreductase (complex I) of the respiratory chain from the inner mitochondrial membrane of Solanum tuberosum."; J. Biol. Chem. 269:2263-2269(1994).

Comments

FUNCTION: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). Component of the iron-sulfur (IP) fragment of the enzyme.
CATALYTIC ACTIVITY: NADH + ubiquinone = NAD⁺ + ubiquinol.
CATALYTIC ACTIVITY: NADH + acceptor = NAD⁺ + reduced acceptor.
SUBUNIT: Complex I is composed of about 30 different subunits. This is a component of the iron-sulfur protein fraction.
SUBCELLULAR LOCATION: Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
RNA EDITING: Modified_positions=13, 26, 28.
SIMILARITY: Belongs to the complex I 49 kDa subunit family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

X75579; CAA53256.1; ALT_SEQ; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

PIR

S46439; S38586.

3D structure databases

ModBase

P80264.

Ontologies

GO:0005746;	Cellular component: mitochondrial respiratory chain (inferred from electronic annotation from UniProtKB-KW).
GO:0008137;	Molecular function: NADH dehydrogenase (ubiquinone) activity (inferred from electronic annotation from EC).
GO:0022900;	Biological process: electron transport chain (inferred from electronic annotation from UniProtKB-KW).
GO:0006810;	Biological process: transport (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.

Family and domain databases

InterPro

IPR014029; NADH-UbQ_OxRdtase_49kDa_CS.
Graphical view of domain structure.

PROSITE

PS00535; COMPLEX1_49K; PARTIAL.

ProtoNet

P80264.

Other

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Direct protein sequencing; Electron transport; Membrane; Mitochondrion; Mitochondrion inner membrane; NAD; Oxidoreductase; Respiratory chain; RNA editing; Transport; Ubiquinone.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`INIT_MET`	`1 1`		`Removed.`
`CHAIN`	`2 >47`	`>46`	`NADH-ubiquinone oxidoreductase 49 kDa subunit.`	`PRO_0000118586`
`NON_TER`	`47 47`

Sequence information

Length: 47 AA [This is the length of the partial sequence of the unprocessed precursor]

Molecular weight: 5278 Da [This is the MW of the partial sequence of the unprocessed precursor]

CRC64: 0494931B92D06A87 [This is a checksum on the sequence]

        10         20         30         40 
MTTKNRQIQN FTLNFGPQHP AAHGVLRLVL EMNGEVVERA EPHIGLL

P80264 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
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	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools