ID   ACVL1_RAT               Reviewed;         504 AA.
AC   P80203; Q63559;
DT   01-OCT-1993, integrated into UniProtKB/Swiss-Prot.
DT   13-APR-2004, sequence version 2.
DT   22-JUL-2008, entry version 78.
DE   RecName: Full=Serine/threonine-protein kinase receptor R3;
DE            Short=SKR3;
DE            EC=2.7.11.30;
DE   AltName: Full=TGF-B superfamily receptor type I;
DE            Short=TSR-I;
DE   Flags: Precursor;
GN   Name=Acvrl1; Synonyms=Acvrlk1;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC   Muroidea; Muridae; Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Sprague-Dawley; TISSUE=Urogenital ridge;
RX   MEDLINE=93372378; PubMed=8395914;
RA   He W.-W., Gustafson M.L., Hirobe S., Donahoe P.K.;
RT   "Developmental expression of four novel serine/threonine kinase
RT   receptors homologous to the activin/transforming growth factor-beta
RT   type II receptor family.";
RL   Dev. Dyn. 196:133-142(1993).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC   STRAIN=Sprague-Dawley; TISSUE=Lung;
RX   MEDLINE=96198306; PubMed=8928814;
RA   Panchenko M.P., Williams M.C., Brody J.S., Yu Q.;
RT   "Type I receptor serine-threonine kinase preferentially expressed in
RT   pulmonary blood vessels.";
RL   Am. J. Physiol. 270:L547-L558(1996).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Lung;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: On ligand binding, forms a receptor complex consisting
CC       of two type II and two type I transmembrane serine/threonine
CC       kinases. Type II receptors phosphorylate and activate type I
CC       receptors which autophosphorylate, then bind and activate SMAD
CC       transcriptional regulators. Receptor for TGF-beta. May bind
CC       activin as well.
CC   -!- CATALYTIC ACTIVITY: ATP + [receptor-protein] = ADP + [receptor-
CC       protein] phosphate.
CC   -!- COFACTOR: Magnesium or manganese (By similarity).
CC   -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane
CC       protein.
CC   -!- TISSUE SPECIFICITY: Urogenital ridge, testis, ovary, brain and
CC       lung. In lung, found exclusively in pulmonary vessels of all
CC       sizes. Also expressed in aorta, vena cava and certain blood
CC       vessels of kidney, spleen, heart and intestine. For most blood
CC       vessels, a higher level of expression is found in endothelium than
CC       in adjacent smooth muscle.
CC   -!- SIMILARITY: Belongs to the protein kinase superfamily. TKL Ser/Thr
CC       protein kinase family. TGFB receptor subfamily.
CC   -!- SIMILARITY: Contains 1 GS domain.
CC   -!- SIMILARITY: Contains 1 protein kinase domain.
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DR   EMBL; L36088; AAC37705.1; -; mRNA.
DR   EMBL; BC083173; AAH83173.1; -; mRNA.
DR   RefSeq; NP_071886.1; -.
DR   UniGene; Rn.10631; -.
DR   HSSP; P36897; 1IAS.
DR   Ensembl; ENSRNOG00000028713; Rattus norvegicus.
DR   GeneID; 25237; -.
DR   KEGG; rno:25237; -.
DR   RGD; 2029; Acvrl1.
DR   HOVERGEN; P80203; -.
DR   ArrayExpress; P80203; -.
DR   GermOnline; ENSRNOG00000028713; Rattus norvegicus.
DR   InterPro; IPR000472; Activin_rcpt.
DR   InterPro; IPR000719; Prot_kinase_core.
DR   InterPro; IPR017441; Protein_kinase_ATP_bd_CS.
DR   InterPro; IPR017442; Se/Thr_pkinase-rel.
DR   InterPro; IPR008271; Ser_thr_pkin_AS.
DR   InterPro; IPR003605; TGF_beta_rcpt_GS.
DR   Pfam; PF01064; Activin_recp; 1.
DR   Pfam; PF00069; Pkinase; 1.
DR   Pfam; PF08515; TGF_beta_GS; 1.
DR   ProDom; PD000001; Prot_kinase; 1.
DR   SMART; SM00467; GS; 1.
DR   PROSITE; PS51256; GS; 1.
DR   PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE   2: Evidence at transcript level;
KW   ATP-binding; Glycoprotein; Kinase; Magnesium; Manganese; Membrane;
KW   Metal-binding; Nucleotide-binding; Receptor;
KW   Serine/threonine-protein kinase; Signal; Transferase; Transmembrane.
FT   SIGNAL        1     20       Potential.
FT   CHAIN        21    504       Serine/threonine-protein kinase receptor
FT                                R3.
FT                                /FTId=PRO_0000024422.
FT   TOPO_DOM     21    121       Extracellular (Potential).
FT   TRANSMEM    122    142       Potential.
FT   TOPO_DOM    143    504       Cytoplasmic (Potential).
FT   DOMAIN      173    202       GS.
FT   DOMAIN      203    504       Protein kinase.
FT   NP_BIND     209    217       ATP (By similarity).
FT   ACT_SITE    331    331       Proton acceptor (By similarity).
FT   BINDING     230    230       ATP (By similarity).
FT   CARBOHYD     34     34       N-linked (GlcNAc...) (Potential).
FT   CARBOHYD     99     99       N-linked (GlcNAc...) (Potential).
FT   CONFLICT    309    309       C -> CA (in Ref. 1).
SQ   SEQUENCE   504 AA;  56703 MW;  B40EA30775223C8F CRC64;
     MTLGIFRRVF LMLSVALGLT KGDLVKPSRG QLVNCTCENP HCKRPICQGA WCTVVLVREQ
     GRHPQVYRGC GSLNQELCLG RPTEFVNHHC CYRSFCNHNV SLMLEATQTP SEEPEVDAHL
     PLILGPVLAL LVLVALGTLG LWRVRRRQEK QRGLHSDLGE SSLILKASEQ GDSMLGDFLV
     SDCTTGSGSG LPFLVQRTVA RQVALVECVG KGRYGEVWRG SWHGESVAVK IFSSRDEQSW
     FRETEIYNTV LLRHDNILGF IASDMTSRNS STQLWLITHY HEHGSLYDFL QRQTLEPQLA
     LRLAVSAACG LAHLHVEIFG TQGKPAIAHR DLKSRNVLVK SNLQCCIADL GLAVMHSQSS
     DYLDIGNNPR VGTKRYMAPE VLDEQIRTDC FESYKWTDIW AFGLVLWEIA RRTIINGIVE
     DYRPPFYDMV PNDPSFEDMK KVVCVDQQTP TIPNRLAADP VLSGLAQMMR ECWYPNPSAR
     LTALRIKKTL QKLSQNPEKP KVIH
//