ID   ACV1B_RAT               Reviewed;         505 AA.
AC   P80202;
DT   01-OCT-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1993, sequence version 1.
DT   22-JUL-2008, entry version 86.
DE   RecName: Full=Activin receptor type-1B;
DE            EC=2.7.11.30;
DE   AltName: Full=ACTR-IB;
DE   AltName: Full=Serine/threonine-protein kinase receptor R2;
DE            Short=SKR2;
DE   Flags: Precursor;
GN   Name=Acvr1b; Synonyms=Acvrlk4;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC   Muroidea; Muridae; Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Sprague-Dawley; TISSUE=Urogenital ridge;
RX   MEDLINE=93372378; PubMed=8395914;
RA   He W.-W., Gustafson M.L., Hirobe S., Donahoe P.K.;
RT   "Developmental expression of four novel serine/threonine kinase
RT   receptors homologous to the activin/transforming growth factor-beta
RT   type II receptor family.";
RL   Dev. Dyn. 196:133-142(1993).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Pituitary;
RX   MEDLINE=95113007; PubMed=7813622; DOI=10.1006/excr.1995.1026;
RA   Takumi T., Moustakas A., Lin H.Y., Lodish H.F.;
RT   "Molecular characterization of a type I serine-threonine kinase
RT   receptor for TGF-beta and activin in the rat pituitary tumor cell line
RT   GH3.";
RL   Exp. Cell Res. 216:208-214(1995).
CC   -!- FUNCTION: On ligand binding, forms a receptor complex consisting
CC       of two type II and two type I transmembrane serine/threonine
CC       kinases. Type II receptors phosphorylate and activate type I
CC       receptors which autophosphorylate, then bind and activate SMAD
CC       transcriptional regulators.
CC   -!- CATALYTIC ACTIVITY: ATP + [receptor-protein] = ADP + [receptor-
CC       protein] phosphate.
CC   -!- COFACTOR: Magnesium or manganese (By similarity).
CC   -!- SUBUNIT: Interacts with AIP1. Part of a complex consisting of
CC       AIP1, ACVR2A, ACVR1B and SMAD3 (By similarity).
CC   -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane
CC       protein.
CC   -!- TISSUE SPECIFICITY: Urogenital ridge, testis, ovary, brain and
CC       lungs.
CC   -!- SIMILARITY: Belongs to the protein kinase superfamily. TKL Ser/Thr
CC       protein kinase family. TGFB receptor subfamily.
CC   -!- SIMILARITY: Contains 1 GS domain.
CC   -!- SIMILARITY: Contains 1 protein kinase domain.
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DR   EMBL; S76466; AAB33045.1; -; mRNA.
DR   RefSeq; NP_954700.1; -.
DR   UniGene; Rn.214018; -.
DR   HSSP; P36897; 1B6C.
DR   SMR; P80202; 173-501.
DR   PhosphoSite; P80202; -.
DR   Ensembl; ENSRNOG00000006934; Rattus norvegicus.
DR   GeneID; 29381; -.
DR   KEGG; rno:29381; -.
DR   NMPDR; fig|10116.3.peg.27799; -.
DR   RGD; 735207; Acvr1b.
DR   HOVERGEN; P80202; -.
DR   ArrayExpress; P80202; -.
DR   GermOnline; ENSRNOG00000006934; Rattus norvegicus.
DR   InterPro; IPR000472; Activin_rcpt.
DR   InterPro; IPR000719; Prot_kinase_core.
DR   InterPro; IPR017441; Protein_kinase_ATP_bd_CS.
DR   InterPro; IPR017442; Se/Thr_pkinase-rel.
DR   InterPro; IPR008271; Ser_thr_pkin_AS.
DR   InterPro; IPR003605; TGF_beta_rcpt_GS.
DR   Pfam; PF01064; Activin_recp; 1.
DR   Pfam; PF00069; Pkinase; 1.
DR   Pfam; PF08515; TGF_beta_GS; 1.
DR   ProDom; PD000001; Prot_kinase; 1.
DR   SMART; SM00467; GS; 1.
DR   PROSITE; PS51256; GS; 1.
DR   PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE   2: Evidence at transcript level;
KW   ATP-binding; Glycoprotein; Kinase; Magnesium; Manganese; Membrane;
KW   Metal-binding; Nucleotide-binding; Phosphoprotein; Receptor;
KW   Serine/threonine-protein kinase; Signal; Transferase; Transmembrane.
FT   SIGNAL        1     23       Potential.
FT   CHAIN        24    505       Activin receptor type-1B.
FT                                /FTId=PRO_0000024419.
FT   TOPO_DOM     24    126       Extracellular (Potential).
FT   TRANSMEM    127    149       Potential.
FT   TOPO_DOM    150    505       Cytoplasmic (Potential).
FT   DOMAIN      177    206       GS.
FT   DOMAIN      207    497       Protein kinase.
FT   NP_BIND     213    221       ATP (By similarity).
FT   ACT_SITE    335    335       Proton acceptor (By similarity).
FT   BINDING     234    234       ATP (By similarity).
FT   MOD_RES     380    380       Phosphotyrosine (By similarity).
FT   CARBOHYD     43     43       N-linked (GlcNAc...) (Potential).
SQ   SEQUENCE   505 AA;  56805 MW;  377F4A5C867B3860 CRC64;
     MAESAGASSF FPLVVLLLAG SGGSGPRGIQ ALLCACTSCL QTNYTCETDG ACMVSIFNLD
     GMEHHVRTCI PKVELVPAGK PFYCLSSEDL RNTHCCYIDF CNKIDLRVPS GHLKEPEHPS
     MWGPVELVGI IAGPVFLLFL IIIIVFLVIN YHQRVYHNRQ RLDMEDPSCE MCLSKDKTLQ
     DLVYDLSTSG SGSGLPLFVQ RTVARTIVLQ EIIGKGRFGE VWRGRWRGGD VAVKIFSSRE
     ERSWFREAEI YQTVMLRHEN ILGFIAADNK DNGTWTQLWL VSDYHEHGSL FDYLNRYTVT
     IEGMIKLALS AASGLAHLHM EIVGTQGKPG IAHRDLKSKN ILVKKNGMCA IADLGLAVRH
     DAVTDTIDIA PNQRVGTKRY MAPEVLDETI NMKHFDSFKC ADIYALGLVY WEIARRCNSG
     GVHEEYQLPY YDLVPSDPSI EEMRKVVCDQ KLRPNVPNWW QSYEALRVMG KMMRECWYAN
     GAARLTALRI KKTLSQLSVQ EDVKI
//