[1]	NUCLEOTIDE SEQUENCE [MRNA]. STRAIN=Sprague-Dawley; TISSUE=Urogenital ridge; PubMed=8395914 [NCBI, ExPASy, EBI, Israel, Japan] He W.-W., Gustafson M.L., Hirobe S., Donahoe P.K.; "Developmental expression of four novel serine/threonine kinase receptors homologous to the activin/transforming growth factor-beta type II receptor family."; Dev. Dyn. 196:133-142(1993).
[2]	NUCLEOTIDE SEQUENCE [MRNA]. STRAIN=Sprague-Dawley; PubMed=8248234 [NCBI, ExPASy, EBI, Israel, Japan] Tsuchida K.K.T., Vale W.W.; "Cloning and characterization of a transmembrane serine kinase that acts as an activin type I receptor."; Proc. Natl. Acad. Sci. U.S.A. 90:11242-11246(1993).

Comments

FUNCTION: On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin. May be involved for left-right pattern formation during embryogenesis (By similarity).
CATALYTIC ACTIVITY: ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.
COFACTOR: Magnesium or manganese (By similarity).
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
TISSUE SPECIFICITY: Urogenital ridge, testis, ovary, brain and lungs.
SIMILARITY: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
SIMILARITY: Contains 1 GS domain.
SIMILARITY: Contains 1 protein kinase domain.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

L19341; AAA40673.1; -; mRNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

A49664; A49664.

NP_077812.1; -.

3D structure databases

HSSP

P36897; 1IAS. [HSSP ENTRY / PDB]

ModBase

P80201.

PTM databases

PhosphoSite

P80201; -.

Organism-specific databases

RGD

620200; Acvr1.

Gene expression databases

ArrayExpress

P80201; -.

GermOnline

ENSRNOG00000005033; Rattus norvegicus.

Ontologies

GO:0048641;	Biological process: regulation of skeletal muscle development (inferred from expression pattern from UniProtKB).
GO:0007179;	Biological process: transforming growth factor beta receptor signaling pathway (inferred from mutant phenotype from UniProtKB).
QuickGo view.

Family and domain databases

InterPro

IPR000333; Activin_II_recpt.
IPR000472; Activin_rcpt.
IPR000719; Prot_kinase_core.
IPR017441; Protein_kinase_ATP_bd_CS.
IPR017442; Se/Thr_pkinase-rel.
IPR008271; Ser_thr_pkin_AS.
IPR003605; TGF_beta_rcpt_GS.
Graphical view of domain structure.

Pfam

PF01064; Activin_recp; 1.
PF00069; Pkinase; 1.
PF08515; TGF_beta_GS; 1.
Pfam graphical view of domain structure.

PRINTS

PR00653; ACTIVIN2R.

ProDom

PD000001; Prot_kinase; 1.
[Domain structure / List of seq. sharing at least 1 domain]

SMART

SM00467; GS; 1.
SMART graphical view of domain structure.

PROSITE

PS51256; GS; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
PROSITE graphical view of domain structure (profiles).

BLOCKS

P80201.

Genome annotation databases

Ensembl

ENSRNOG00000005033; Rattus norvegicus. [Contig view]

GeneID

79558; -.

KEGG

rno:79558; -.

Phylogenomic databases

HOVERGEN

P80201; -.

Other

ProtoNet

P80201.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

ATP-binding; Glycoprotein; Kinase; Magnesium; Manganese; Membrane; Metal-binding; Nucleotide-binding; Phosphoprotein; Receptor; Serine/threonine-protein kinase; Signal; Transferase; Transmembrane.

Features

Feature table viewer

Feature aligner

`Key`	`From To`	`Length`	`Description`	`FTId`
`SIGNAL`	`1 20`	`20`	`Potential.`
`CHAIN`	`21 509`	`489`	`Activin receptor type-1.`	`PRO_0000024396`
`TOPO_DOM`	`21 123`	`103`	`Extracellular (Potential).`
`TRANSMEM`	`124 146`	`23`	`Potential.`
`TOPO_DOM`	`147 509`	`363`	`Cytoplasmic (Potential).`
`DOMAIN`	`178 207`	`30`	`GS.`
`DOMAIN`	`208 502`	`295`	`Protein kinase.`
`NP_BIND`	`214 222`	`9`	`ATP (By similarity).`
`ACT_SITE`	`336 336`		`Proton acceptor (By similarity).`
`BINDING`	`235 235`		`ATP (By similarity).`
`MOD_RES`	`501 501`		`Phosphoserine (By similarity).`
`CARBOHYD`	`102 102`		`N-linked (GlcNAc...) (Potential).`

Sequence information

Length: 509 AA [This is the length of the unprocessed precursor]

Molecular weight: 57195 Da [This is the MW of the unprocessed precursor]

CRC64: 7A70A477784DCF87 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MVDGAMILSV LMMMALPSPS MEDEEPKVNP KLYMCVCEGL SCGNEDHCEG QQCFSSLSVN 

        70         80         90        100        110        120 
DGFRVYQKGC FQVYEQGKMT CKTPPSPGQA VECCQGDWCN RNVTARLPTK GKSFPGSQNF 

       130        140        150        160        170        180 
HLEVGLIILS VVFAVCLFAC ILGVALRKFK RRNQERLNPR DVEYGTIEGL ITTNVGDSTL 

       190        200        210        220        230        240 
AELLDHSCTS GSGSGLPFLV QRTVARQITL LECVGKGRYG EVWRGSWQGE NVAVKIFSSR 

       250        260        270        280        290        300 
DEKSWFRETE LYNTVMLRHE NILGFIASDM TSRHSSTQLW LITHYHEMGS LYDYLQLTTL 

       310        320        330        340        350        360 
DTVSCLRIVL SIASGLAHLH IEIFGTQGKS AIAHRDLKSK NILVKKNGQC CIADLGLAVM 

       370        380        390        400        410        420 
HSQSTNQLDV GNNPRVGTKR YMAPEVLDET IQVDCFDSYK RVDIWAFGLV LWEVARRMVS 

       430        440        450        460        470        480 
NGIVEDYKPP FYDVVPNDPS FEDMRKVVCV DQQRPNIPNR WFSDPTLTSL AKLMKECWYQ 

       490        500 
NPSARLTALR IKKTLTKIDN SLDKLKTDC

P80201 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools