ID   HPPD_PSEUJ              Reviewed;         357 AA.
AC   P80064;
DT   01-MAY-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1992, sequence version 1.
DT   22-JUL-2008, entry version 64.
DE   RecName: Full=4-hydroxyphenylpyruvate dioxygenase;
DE            Short=HPPDase;
DE            Short=4HPPD;
DE            Short=HPD;
DE            EC=1.13.11.27;
GN   Name=hpd;
OS   Pseudomonas sp. (strain P.J. 874).
OC   Bacteria; Proteobacteria.
OX   NCBI_TaxID=72587;
RN   [1]
RP   PROTEIN SEQUENCE.
RX   MEDLINE=92241278; PubMed=1572351;
RA   Rueetschi U., Odelhoeg B., Lindstedt S., Barros-Soederling J.,
RA   Persson B., Joernvall H.;
RT   "Characterization of 4-hydroxyphenylpyruvate dioxygenase. Primary
RT   structure of the Pseudomonas enzyme.";
RL   Eur. J. Biochem. 205:459-466(1992).
RN   [2]
RP   X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS).
RX   MEDLINE=99404943; PubMed=10467142; DOI=10.1016/S0969-2126(99)80124-5;
RA   Serre L., Sailland A., Sy D., Boudec P., Rolland A.,
RA   Pebay-Peyroula E., Cohen-Addad C.;
RT   "Crystal structure of Pseudomonas fluorescens 4-hydroxyphenylpyruvate
RT   dioxygenase: an enzyme involved in the tyrosine degradation pathway.";
RL   Structure 7:977-988(1999).
CC   -!- CATALYTIC ACTIVITY: 4-hydroxyphenylpyruvate + O(2) = homogentisate
CC       + CO(2).
CC   -!- COFACTOR: Binds 1 iron ion per subunit.
CC   -!- PATHWAY: Amino-acid degradation; L-phenylalanine degradation;
CC       acetoacetic acid and fumarate from L-phenylalanine: step 3/6.
CC   -!- SUBUNIT: Homotetramer.
CC   -!- SIMILARITY: Belongs to the 4HPPD family.
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DR   PIR; S21209; S21209.
DR   PDB; 1CJX; X-ray; 2.40 A; A/B/C/D=1-357.
DR   PDBsum; 1CJX; -.
DR   BioCyc; MetaCyc:MON-12032; -.
DR   InterPro; IPR005956; 4OHPhenylPyrv_dOase.
DR   InterPro; IPR004360; Glyas_bleo-R_dOase.
DR   PANTHER; PTHR11959; HPP_dOase; 1.
DR   Pfam; PF00903; Glyoxalase; 1.
DR   PIRSF; PIRSF009283; HPP_dOase; 1.
DR   TIGRFAMs; TIGR01263; 4HPPD; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Dioxygenase; Direct protein sequencing; Iron;
KW   Metal-binding; Oxidoreductase; Phenylalanine catabolism;
KW   Tyrosine catabolism.
FT   CHAIN         1    357       4-hydroxyphenylpyruvate dioxygenase.
FT                                /FTId=PRO_0000088408.
FT   COMPBIAS    167    196       Tyr-rich.
FT   METAL       161    161       Iron.
FT   METAL       240    240       Iron.
FT   METAL       322    322       Iron.
FT   STRAND       10     19
FT   HELIX        27     32
FT   STRAND       36     51
FT   STRAND       54     59
FT   STRAND       62     64
FT   HELIX        65     73
FT   STRAND       74     85
FT   HELIX        87     96
FT   STRAND      115    117
FT   HELIX       119    121
FT   STRAND      123    127
FT   STRAND      131    133
FT   HELIX       136    140
FT   STRAND      141    143
FT   STRAND      155    162
FT   HELIX       170    182
FT   STRAND      185    193
FT   STRAND      198    205
FT   STRAND      212    218
FT   HELIX       225    233
FT   STRAND      235    237
FT   STRAND      240    246
FT   HELIX       248    257
FT   HELIX       268    272
FT   HELIX       274    277
FT   HELIX       285    291
FT   STRAND      294    300
FT   STRAND      303    312
FT   STRAND      319    328
FT   HELIX       334    351
SQ   SEQUENCE   357 AA;  40061 MW;  26CF4A80B1484BD0 CRC64;
     ADLYENPMGL MGFEFIELAS PTPNTLEPIF EIMGFTKVAT HRSKDVHLYR QGAINLILNN
     EPHSVASYFA AEHGPSVCGM AFRVKDSQKA YKRALELGAQ PIHIETGPME LNLPAIKGIG
     GAPLYLIDRF GEGSSIYDID FVFLEGVDRH PVGAGLKIID HLTHNVYRGR MAYWANFYEK
     LFNFREIRYF DIKGEYTGLT SKAMTAPDGM IRIPLNEESS KGAGQIEEFL MQFNGEGIQH
     VAFLSDDLIK TWDHLKSIGM RFMTAPPDTY YEMLEGRLPN HGEPVGELQA RGILLDGSSE
     SGDKRLLLQI FSETLMGPVF FEFIQRKGDD GFGEGNFKAL FESIERDQVR RGVLSTD
//