PROTEIN SEQUENCE.
TISSUE=Venom;
PubMed=2013276 [NCBI, ExPASy, EBI, Israel, Japan]
Vandermeers A., Vandermeers-Piret M.-C., Vigneron L., Rathe J., Stievenart M., Christophe J.;
"Differences in primary structure among five phospholipases A2 from Heloderma suspectum.";
Eur. J. Biochem. 196:537-544(1991).

Comments

FUNCTION: PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.
CATALYTIC ACTIVITY: Phosphatidylcholine + H₂O = 1-acylglycerophosphocholine + a carboxylate.
COFACTOR: Binds 1 calcium ion per subunit (By similarity).
SUBCELLULAR LOCATION: Secreted.
TISSUE SPECIFICITY: Expressed by the venom gland.
SIMILARITY: Belongs to the phospholipase A2 family.

Copyright

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Cross-references

Sequence databases
PIR	S25093; S25093.
3D structure databases
HSSP	P00630; 1POC. [HSSP ENTRY / PDB]
ModBase	P80003.
Family and domain databases
InterPro	IPR016090; Phospholipase_A2. IPR013090; Phospholipase_A2_AS. IPR001211; Phospholipase_A2_euk. IPR008774; Phospholipase_A2_met. Graphical view of domain structure.
Gene3D	G3DSA:1.20.90.10; Phospholipase_A2; 1.
PANTHER	PTHR12253; Phospholipase_A2_met; 1.
Pfam	PF05826; Phospholip_A2_2; 1. Pfam graphical view of domain structure.
SMART	SM00085; PA2c; 1. SMART graphical view of domain structure.
PROSITE	PS00119; PA2_ASP; FALSE_NEG. PS00118; PA2_HIS; 1.
BLOCKS	P80003.
Phylogenomic databases
HOVERGEN	P80003; -.
Other
ProtoNet	P80003.
UniRef	View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Calcium; Direct protein sequencing; Hydrolase; Lipid degradation; Metal-binding; Secreted.

Features

Feature table viewer

Feature aligner

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 142`	`142`	`Phospholipase A2 isozyme PA4.`	`PRO_0000045885`
`CHAIN`	`1 141`	`141`	`Phospholipase A2 isozyme PA2.`	`PRO_0000045886`
`ACT_SITE`	`36 36`		`By similarity.`
`METAL`	`10 10`		`Calcium; via carbonyl oxygen (By similarity).`
`METAL`	`12 12`		`Calcium; via carbonyl oxygen (By similarity).`
`METAL`	`14 14`		`Calcium; via carbonyl oxygen (By similarity).`
`METAL`	`37 37`		`Calcium (By similarity).`
`DISULFID`	`11 33`		`By similarity.`
`DISULFID`	`32 72`		`By similarity.`
`DISULFID`	`39 65`		`By similarity.`

Sequence information

Length: 142 AA [This is the length of the unprocessed precursor]

Molecular weight: 15640 Da [This is the MW of the unprocessed precursor]

CRC64: 9B79D5F5CD775E3B [This is a checksum on the sequence]

        10         20         30         40         50         60 
GAFIMPGTLW CGAGNAASDY SQLGTEKDTD MCCRDHDHCS DTMAALEYKH GMRNYRPHTV 

        70         80         90        100        110        120 
SHCDCDNQFR SCLMNVKDRT ADLVGMTYFT VLKISCFELE EGEGCVDNNF SQQCTKSEIM 

       130        140 
PVAKLVSAAP YQAQAETQSG EG

P80003 in FASTA format

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View entry in raw text format (no links)
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	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools