ExPASy logo ExPASy Home page Site Map Search ExPASy Contact us Swiss-Prot
Notice: This page will be replaced with www.uniprot.org. Please send us your feedback!
Search for

UniProtKB/Swiss-Prot entry P79739

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

Note: most headings are clickable, even if they don't appear as links. They link to the user manual or other documents.
Entry information
Entry name CP26A_DANRE
Primary accession number P79739
Secondary accession numbers None
Integrated into Swiss-Prot on December 15, 1998
Sequence was last modified on May 1, 1997 (Sequence version 1)
Annotations were last modified on    June 16, 2009 (Entry version 62)
Name and origin of the protein
Protein name Cytochrome P450 26A1
Synonyms EC 1.14.-.-
Retinoic acid-metabolizing cytochrome
P450RAI
Retinoic acid 4-hydroxylase
Gene name
Name: cyp26a1
Synonyms: cyp26
From
Danio rerio (Zebrafish) (Brachydanio rerio) [TaxID: 7955] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Cyprinidae; Danio.
Protein existence 2: Evidence at transcript level;
References
[1]
 NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND INDUCTION.
DOI=10.1074/jbc.271.47.29922; PubMed=8939936 [NCBI, ExPASy, EBI, Israel, Japan]
White J.A., Guo Y.-D., Baetz K., Beckett-Jones B., Bonasoro J., Hsu K.E., Dilworth F.J., Jones G., Petkovich M.;
"Identification of the retinoic acid-inducible all-trans-retinoic acid 4-hydroxylase.";
J. Biol. Chem. 271:29922-29927(1996).
Comments
  • FUNCTION: Plays a key role in retinoic acid metabolism. Acts on retinoids, including all-trans-retinoic acid (RA) and its stereoisomer 9-cis-RA. Capable of 4-hydroxylation. Responsible for generation of several hydroxylated forms of RA, including 4-OH-RA and 4-oxo-RA.
  • COFACTOR: Heme group (By similarity).
  • SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
  • INDUCTION: By retinoic acid.
  • SIMILARITY: Belongs to the cytochrome P450 family.
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
U68234; AAC60045.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
IPI IPI00489219; -.
UniGene Dr.75754
3D structure databases
ModBase P79739.
Organism-specific databases
ZFIN ZDB-GENE-990415-44; cyp26a1.
Gene expression databases
ArrayExpress P79739; -.
Bgee P79739; -.
Ontologies
GO
GO:0005789; Cellular component: endoplasmic reticulum membrane (inferred from electronic annotation from UniProtKB-SubCell).
GO:0005792; Cellular component: microsome (inferred from electronic annotation from UniProtKB-SubCell).
GO:0009055; Molecular function: electron carrier activity (inferred from electronic annotation from InterPro).
GO:0020037; Molecular function: heme binding (inferred from electronic annotation from InterPro).
GO:0004497; Molecular function: monooxygenase activity (inferred from electronic annotation from UniProtKB-KW).
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR001128; Cyt_P450.
IPR017973; Cyt_P450_C.
IPR017972; Cyt_P450_CS.
IPR002401; Cyt_P450_E_grp-I.
Graphical view of domain structure.
Gene3D G3DSA:1.10.630.10; Cyt_P450; 1.
PANTHER PTHR19383; Cyt_P450; 1.
Pfam PF00067; p450; 1.
Pfam graphical view of domain structure.
PRINTS PR00463; EP450I.
PR00385; P450.
PROSITE PS00086; CYTOCHROME_P450; 1.
Genome annotation databases
Ensembl ENSDARG00000033999; Danio rerio. [Contig view]
Phylogenomic databases
HOGENOM P79739; -.
HOVERGEN P79739; -.
Other
ProtoNet P79739.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Endoplasmic reticulum; Heme; Iron; Membrane; Metal-binding; Microsome; Monooxygenase; Oxidoreductase.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   492  492     Cytochrome P450 26A1. PRO_0000051983
METAL   438   438        Iron (heme axial ligand) (By similarity). 
Sequence information
Length: 492 AA [This is the length of the unprocessed precursor] Molecular weight: 56281 Da [This is the MW of the unprocessed precursor] CRC64: FD471435B2F30509 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MGLYTLMVTF LCTIVLPVLL FLAAVKLWEM LMIRRVDPNC RSPLPPGTMG LPFIGETLQL 

        70         80         90        100        110        120 
ILQRRKFLRM KRQKYGCIYK THLFGNPTVR VMGADNVRQI LLGEHKLVSV QWPASVRTIL 

       130        140        150        160        170        180 
GSDTLSNVHG VQHKNKKKAI MRAFSRDALE HYIPVIQQEV KSAIQEWLQK DSCVLVYPEM 

       190        200        210        220        230        240 
KKLMFRIAMR ILLGFEPEQI KTDEQELVEA FEEMIKNLFS LPIDVPFSGL YRGLRARNFI 

       250        260        270        280        290        300 
HSKIEENIRK KIQDDDNENE QKYKDALQLL IENSRRSDEP FSLQAMKEAA TELLFGGHET 

       310        320        330        340        350        360 
TASTATSLVM FLGLNTEVVQ KVREEVQEKV EMGMYTPGKG LSMELLDQLK YTGCVIKETL 

       370        380        390        400        410        420 
RINPPVPGGF RVALKTFELN GYQIPKGWNV IYSICDTHDV ADVFPNKEEF QPERFMSKGL 

       430        440        450        460        470        480 
EDGSRFNYIP FGGGSRMCVG KEFAKVLLKI FLVELTQHCN WILSNGPPTM KTGPTIYPVD 

       490 
NLPTKFTSYV RN
P79739 in FASTA format

View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

BLAST logo BLAST submission on ExPASy/SIB
or at NCBI (USA) 		Tools Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
PROSITE logo ScanProsite, MotifScan SWISS-MODEL Submit a homology modeling request to SWISS-MODEL
NPSA logo NPSA Sequence analysis tools

ExPASy logo ExPASy Home page Site Map Search ExPASy Contact us Swiss-Prot
Hosted by ch flag SIB Switzerland Mirror sites: Australia Brazil Canada China Korea
Notice: This page will be replaced with www.uniprot.org. Please send us your feedback!