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UniProtKB/Swiss-Prot entry P79089

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name IDHP_ASPNG
Primary accession number P79089
Secondary accession numbers None
Integrated into Swiss-Prot on July 15, 1998
Sequence was last modified on May 1, 1997 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 47)
Name and origin of the protein
Protein name Isocitrate dehydrogenase [NADP], mitochondrial [Precursor]
Synonyms IDH
EC 1.1.1.42
Oxalosuccinate decarboxylase
NADP(+)-specific ICDH
IDP
Gene name
Name: icdA
From
Aspergillus niger [TaxID: 5061] 
Taxonomy Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes; Eurotiomycetidae; Eurotiales; Trichocomaceae; mitosporic Trichocomaceae; Aspergillus.
Protein existence 2: Evidence at transcript level;
References
[1]
 NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
STRAIN=WU-2223L;
DOI=10.1263/jbb.93.136; PubMed=16233178 [NCBI, ExPASy, EBI, Israel, Japan]
Kirimura K., Yoda M., Kumagai M., Ishii Y., Kino K., Usami S.;
"Cloning and expression of Aspergillus niger icdA gene encoding mitochondrial NADP+-specific isocitrate dehydrogenase.";
J. Biosci. Bioeng. 93:136-144(2002).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AB000262; BAA19074.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AB000261; BAA19073.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
3D structure databases
HSSP P33198; 1LWD. [HSSP ENTRY / PDB]
SMR P79089; 92-494.
ModBase P79089.
Family and domain databases
InterPro IPR004790; IsoCit_DHase_NADP-dep_euk.
IPR001804; IsoCit_IM_DHase.
Graphical view of domain structure.
Gene3D G3DSA:3.40.718.10; IDH_IMDH; 1.
PANTHER PTHR11822; IDH_NADP_euk; 1.
Pfam PF00180; Iso_dh; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF000108; IDH_NADP; 1.
TIGRFAMs TIGR00127; nadp_idh_euk; 1.
PROSITE PS00470; IDH_IMDH; 1.
BLOCKS P79089.
Other
ProtoNet P79089.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Glyoxylate bypass; Magnesium; Manganese; Metal-binding; Mitochondrion; NADP; Oxidoreductase; Transit peptide; Tricarboxylic acid cycle.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
TRANSIT   1     ?        Mitochondrion. 
CHAIN   ?   498        Isocitrate dehydrogenase [NADP], mitochondrial. PRO_0000014423
NP_BIND   164   166  3     NADP (By similarity). 
NP_BIND   397   402  6     NADP (By similarity). 
REGION   183   189  7     Substrate binding (By similarity). 
METAL   339   339        Magnesium or manganese (By similarity). 
METAL   362   362        Magnesium or manganese (By similarity). 
BINDING   166   166        Substrate (By similarity). 
BINDING   171   171        NADP (By similarity). 
BINDING   198   198        Substrate (By similarity). 
BINDING   221   221        Substrate (By similarity). 
BINDING   347   347        NADP (By similarity). 
BINDING   415   415        NADP; via amide nitrogen and carbonyl oxygen (By similarity). 
SITE   228   228  1     Critical for catalysis (By similarity). 
SITE   299   299  1     Critical for catalysis (By similarity). 
Sequence information
Length: 498 AA [This is the length of the unprocessed precursor] Molecular weight: 55559 Da [This is the MW of the unprocessed precursor] CRC64: 60FAB99B0A315CF0 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MSSVRFSSAL ARRSFAVASP PLSAPLSSSA RRFLSSSSST ISSSSSSVST RSPRSLTSAS 

        70         80         90        100        110        120 
SLLSSRTASA RWTGLSSLNL TQSRTMATEI PKIKVKNPVV ELDGDEMTRI IWQEIREKLI 

       130        140        150        160        170        180 
LPYLDVDLKY YDLGLEYRDQ TDDQVTVEAA EAIKKYGVGV KCATITPDEA RVEEFKLKKM 

       190        200        210        220        230        240 
WLSPNGTIRN ILGGTVFREP IIIPAIPRLV PGWNKPIIIG RHAFGDQYRA TDRVIPGPGK 

       250        260        270        280        290        300 
LELVYTPVNG EPETVKVYDF QGGGIAQTQY NTDESIRGFA HASFQMALLK GLPLYMSTKN 

       310        320        330        340        350        360 
TILKRYDGRF KDIFQEIYES TYQKDFEAKN LWYEHRLIDD MVAQMIKSEG GFVMALKNYD 

       370        380        390        400        410        420 
GDVQSDIVAQ GFGSLGLMTS TLVTPTGEAF ESEAAHGTVT RHYREHQKGR ETSTNPIASI 

       430        440        450        460        470        480 
FAWTRGLIQR GKLDETPDVV TFAEELERAC IEVVNDEGIM TKDLALACGR KEREAWVTTR 

       490 
EYMAAVERRL KANLKSRL
P79089 in FASTA format

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