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UniProtKB/Swiss-Prot entry P78715

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name MAOH_NEOFR
Primary accession number P78715
Secondary accession numbers None
Integrated into Swiss-Prot on January 16, 2004
Sequence was last modified on May 1, 1997 (Sequence version 1)
Annotations were last modified on    September 2, 2008 (Entry version 50)
Name and origin of the protein
Protein name Malic enzyme, hydrogenosomal [Precursor]
Synonyms ME
EC 1.1.1.40
Gene name None
From
Neocallimastix frontalis (Rumen fungus) [TaxID: 4757] 
Taxonomy Eukaryota; Fungi; Neocallimastigomycota; Neocallimastigomycetes; Neocallimastigales; Neocallimastigaceae; Neocallimastix.
Protein existence 1: Evidence at protein level;
References
[1]
 NUCLEOTIDE SEQUENCE [MRNA], AND PARTIAL PROTEIN SEQUENCE.
STRAIN=L2;
PubMed=9004216 [NCBI, ExPASy, EBI, Israel, Japan]
van der Giezen M., Rechinger K.B., Svendsen I., Durand R., Hirt R.P., Fevre M., Embley T.M., Prins R.A.;
"A mitochondrial-like targeting signal on the hydrogenosomal malic enzyme from the anaerobic fungus Neocallimastix frontalis: support for the hypothesis that hydrogenosomes are modified mitochondria.";
Mol. Microbiol. 23:11-21(1997).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
U62041; AAC49572.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
3D structure databases
HSSP P40927; 1GQ2. [HSSP ENTRY / PDB]
ModBase P78715.
Family and domain databases
InterPro IPR015884; Malic_enzyme_CS.
IPR012301; Malic_N.
IPR012302; Malic_NAD_bd.
IPR001891; Malic_OxRdtase.
IPR016040; NAD(P)-bd.
IPR002035; VWF_A.
Graphical view of domain structure.
Gene3D G3DSA:3.40.50.720; NAD(P)-bd; 1.
Pfam PF00390; malic; 1.
PF03949; Malic_M; 1.
Pfam graphical view of domain structure.
PRINTS PR00072; MALOXRDTASE.
PR00453; VWFADOMAIN.
PROSITE PS00331; MALIC_ENZYMES; 1.
BLOCKS P78715.
Other
ProtoNet P78715.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Direct protein sequencing; Hydrogenosome; Metal-binding; NADP; Oxidoreductase; Transit peptide.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
TRANSIT   1    27  27     Hydrogenosome. 
CHAIN   28   592  565     Malic enzyme, hydrogenosomal. PRO_0000018549
NP_BIND   182   205  24     NADP (By similarity). 
NP_BIND   335   352  18     NADP (By similarity). 
ACT_SITE   134   134        Proton donor (By similarity). 
ACT_SITE   205   205        Proton acceptor (By similarity). 
METAL   276   276        Divalent metal cation (By similarity). 
METAL   277   277        Divalent metal cation (By similarity). 
METAL   300   300        Divalent metal cation (By similarity). 
BINDING   187   187        NAD (By similarity). 
BINDING   300   300        NAD (By similarity). 
BINDING   443   443        NAD (By similarity). 
SITE   300   300  1     Important for activity (By similarity). 
Sequence information
Length: 592 AA [This is the length of the unprocessed precursor] Molecular weight: 65546 Da [This is the MW of the unprocessed precursor] CRC64: 5BB891C4FDA127BF [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MLAPIQTIAR PVSSILPATG ALAAKRTFFA PSEVYNKKQV IVTKKTGLDI LNDPKLNKGS 

        70         80         90        100        110        120 
AFTADEKDRL GIRGLVPPRP QSLEAQYKRC KTNLDKISDP LEKFIYLNHL QNRNETLYYK 

       130        140        150        160        170        180 
MILENFVELA PIIYTPVVGE ACQKFHKIFT QTRGMYFSTA DRGQMSAVAA NWPYDDVDVI 

       190        200        210        220        230        240 
VVTDGSRILG LGDLGAGGMQ IPIGKLTLYV CGGGINPRNV LPIVLDVGTN NKELLNDPLY 

       250        260        270        280        290        300 
LGMQHPRLQG EEFHAFVDEW VSAITDRFPK AVIQFEDFMM PNALDLLLKY KDQICMFNDD 

       310        320        330        340        350        360 
IQSTGAITLA SVLATMRARG GTFADIKKET FLCLGAGSSG VGVCETIVDC IVAEGATREE 

       370        380        390        400        410        420 
AYAQFYMFDH KGLLGKGRDD LLPSQQVFMR KEIEGGKTPA ELLKKIKPTC LLGLSTCPKL 

       430        440        450        460        470        480 
FNKEMLSYVA SYCEKPGIFP LSNPTSRSEC TAEEAVEFTD GNLIFASGSP FDPVEWKGKT 

       490        500        510        520        530        540 
IQTNQCNNSY SFPGIGLGLV SSRATRVPFE TFQVCARVIA SLGTPEMLAT GKIFPDLDNL 

       550        560        570        580        590 
RAVSLEVGIE VAKMAERMNI ATQFPPKGMD WREWLKHNMW QPEYPHIVVK NL
P78715 in FASTA format

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