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UniProtKB/Swiss-Prot entry P78395


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name MAPE_HUMAN
Primary accession number P78395
Secondary accession numbers O43481 Q8IXN8
Integrated into Swiss-Prot on May 30, 2000
Sequence was last modified on May 1, 1997 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 64)
Name and origin of the protein
Protein name Melanoma antigen preferentially expressed in tumors
Synonyms Preferentially expressed antigen of melanoma
OPA-interacting protein 4
OIP4
Gene name
Name: PRAME
Synonyms: MAPE
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [MRNA].
DOI=10.1016/S1074-7613(00)80426-4; PubMed=9047241 [NCBI, ExPASy, EBI, Israel, Japan]
Ikeda H., Lethe B.G., Lehmann F., van Baren N., Baurain J.-F., de Smet C., Chambost H., Vitale M., Moretta A., Boon T., Coulie P.G.;
"Characterization of an antigen that is recognized on a melanoma showing partial HLA loss by CTL expressing an NK inhibitory receptor.";
Immunity 6:199-208(1997).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT ARG-7.
DOI=10.1186/gb-2004-5-10-r84; PubMed=15461802 [NCBI, ExPASy, EBI, Israel, Japan]
Collins J.E., Wright C.L., Edwards C.A., Davis M.P., Grinham J.A., Cole C.G., Goward M.E., Aguado B., Mallya M., Mokrab Y., Huckle E.J., Beare D.M., Dunham I.;
"A genome annotation-driven approach to cloning the human ORFeome.";
Genome Biol. 5:RESEARCH84.1-RESEARCH84.11(2004).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT ARG-7.
TISSUE=Brain, Skin, and Testis;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[4]
NUCLEOTIDE SEQUENCE [MRNA] OF 452-509.
PubMed=9466265 [NCBI, ExPASy, EBI, Israel, Japan]
Williams J.M., Chen G.-C., Zhu L., Rest R.F.;
"Using the yeast two-hybrid system to identify human epithelial cell proteins that bind gonococcal Opa proteins: intracellular gonococci bind pyruvate kinase via their Opa proteins and require host pyruvate for growth.";
Mol. Microbiol. 27:171-186(1998).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
U65011; AAC51160.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
CR456549; CAG30435.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC014074; AAH14074.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC022008; AAH22008.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC039731; AAH39731.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF025440; AAC39560.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_006106.1; -.
NP_996836.1; -.
NP_996837.1; -.
NP_996838.1; -.
NP_996839.1; -.
UniGene Hs.30743
3D structure databases
ModBase P78395.
Protein-protein interaction databases
IntAct P78395; -.
Organism-specific databases
H-InvDB HIX0016292; -.
HIX0023687; -.
HIX0028656; -.
HIX0029617; -.
HIX0029716; -.
HIX0056767; -.
HIX0056782; -.
HIX0056783; -.
HIX0056892; -.
HGNC HGNC:9336; PRAME.
GenAtlas PRAME.
MIM 606021; gene. [NCBI / EBI]
PharmGKB PA33698; -.
GeneCards P78395.
Gene expression databases
ArrayExpress P78395; -.
CleanEx HS_PRAME; -.
GermOnline ENSG00000185686; Homo sapiens.
Ontologies
GO
GO:0005515; Molecular function: protein binding (inferred from physical interaction from IntAct).
QuickGo view.
Family and domain databases
InterPro IPR001611; LRR.
Graphical view of domain structure.
Pfam PF00560; LRR_1; 2.
Pfam graphical view of domain structure.
BLOCKS P78395.
Proteomic databases
PeptideAtlas P78395; -.
Genome annotation databases
Ensembl ENSG00000185686; Homo sapiens. [Contig view]
GeneID 23532; -.
KEGG hsa:23532; -.
Phylogenomic databases
HOGENOM P78395; -.
HOVERGEN P78395; -.
Other
LinkHub P78395; -.
SOURCE PRAME; Homo sapiens.
ProtoNet P78395.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Leucine-rich repeat; Polymorphism; Repeat.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   509  509     Melanoma antigen preferentially expressed in tumors. PRO_0000156973
REPEAT   32    55  24     LRR 1. 
REPEAT   116   138  23     LRR 2. 
REPEAT   259   283  25     LRR 3. 
REPEAT   321   344  24     LRR 4. 
REPEAT   348   371  24     LRR 5. 
REPEAT   405   429  25     LRR 6. 
REPEAT   454   477  24     LRR 7. 
VARIANT   7     7  1     W -> R (in dbSNP:rs2266988 [NCBI]). VAR_021258 
CONFLICT   452   452        H -> D (in Ref. 4; AAC39560). 
Sequence information
Length: 509 AA [This is the length of the unprocessed precursor] Molecular weight: 57890 Da [This is the MW of the unprocessed precursor] CRC64: B5FFF3E7F7E82606 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MERRRLWGSI QSRYISMSVW TSPRRLVELA GQSLLKDEAL AIAALELLPR ELFPPLFMAA 

        70         80         90        100        110        120 
FDGRHSQTLK AMVQAWPFTC LPLGVLMKGQ HLHLETFKAV LDGLDVLLAQ EVRPRRWKLQ 

       130        140        150        160        170        180 
VLDLRKNSHQ DFWTVWSGNR ASLYSFPEPE AAQPMTKKRK VDGLSTEAEQ PFIPVEVLVD 

       190        200        210        220        230        240 
LFLKEGACDE LFSYLIEKVK RKKNVLRLCC KKLKIFAMPM QDIKMILKMV QLDSIEDLEV 

       250        260        270        280        290        300 
TCTWKLPTLA KFSPYLGQMI NLRRLLLSHI HASSYISPEK EEQYIAQFTS QFLSLQCLQA 

       310        320        330        340        350        360 
LYVDSLFFLR GRLDQLLRHV MNPLETLSIT NCRLSEGDVM HLSQSPSVSQ LSVLSLSGVM 

       370        380        390        400        410        420 
LTDVSPEPLQ ALLERASATL QDLVFDECGI TDDQLLALLP SLSHCSQLTT LSFYGNSISI 

       430        440        450        460        470        480 
SALQSLLQHL IGLSNLTHVL YPVPLESYED IHGTLHLERL AYLHARLREL LCELGRPSMV 

       490        500 
WLSANPCPHC GDRTFYDPEP ILCPCFMPN 

P78395 in FASTA format

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View entry in raw text format (no links)
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