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UniProtKB/Swiss-Prot entry P78332


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name RBM6_HUMAN
Primary accession number P78332
Secondary accession numbers O60549 O75524
Integrated into Swiss-Prot on January 24, 2001
Sequence was last modified on October 17, 2006 (Sequence version 5)
Annotations were last modified on    June 16, 2009 (Entry version 85)
Name and origin of the protein
Protein name RNA-binding protein 6
Synonyms RNA-binding motif protein 6
RNA-binding protein DEF-3
Lung cancer antigen NY-LU-12
Protein G16
Gene name
Name: RBM6
Synonyms: DEF3
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Lung;
PubMed=9500467 [NCBI, ExPASy, EBI, Israel, Japan]
Gure A.O., Altorki N.K., Stockert E., Scanlan M.J., Old L.J., Chen Y.-T.;
"Human lung cancer antigens recognized by autologous antibodies: definition of a novel cDNA derived from the tumor suppressor gene locus on chromosome 3p21.3.";
Cancer Res. 58:1034-1041(1998).
[2]
NUCLEOTIDE SEQUENCE [MRNA].
DOI=10.1038/sj.ejhg.5200334; PubMed=10352938 [NCBI, ExPASy, EBI, Israel, Japan]
Timmer T., Terpstra P., van den Berg A., Veldhuis P.M., Ter Elst A., Voutsinas G., Hulsbeek M.M.F., Draaijers T.G., Looman M.W.G., Kok K., Naylor S.L., Buys C.H.C.M.;
"A comparison of genomic structures and expression patterns of two closely related flanking genes in a critical lung cancer region at 3p21.3.";
Eur. J. Hum. Genet. 7:478-486(1999).
[3]
NUCLEOTIDE SEQUENCE [MRNA].
DOI=10.1038/sj.onc.1202601; PubMed=10353602 [NCBI, ExPASy, EBI, Israel, Japan]
Drabkin H.A., West J.D., Hotfilder M., Heng Y.M., Erickson P., Calvo R., Dalmau J., Gemmill R.M., Sablitzky F.;
"DEF-3(g16/NY-LU-12), an RNA binding protein from the 3p21.3 homozygous deletion region in SCLC.";
Oncogene 18:2589-2597(1999).
[4]
NUCLEOTIDE SEQUENCE [MRNA].
Latif F., Duh F.-M., Wei M.H., Sekido Y., Forgacs E., Minna J.D., Lerman M.I.;
"A highly conserved and universally expressed gene is interrupted by a homozygous deletion in a small cell lung cancer cell line NCI-H740.";
Submitted (SEP-1998) to the EMBL/GenBank/DDBJ databases.
[5]
DISCUSSION OF SEQUENCE, AND VARIANT NSCLC PHE-353.
PubMed=11085536 [NCBI, ExPASy, EBI, Israel, Japan]
The international lung cancer chromosome 3p21.3 tumor suppressor gene consortium;
Lerman M.I., Minna J.D.;
"The 630-kb lung cancer homozygous deletion region on human chromosome 3p21.3: identification and evaluation of the resident candidate tumor suppressor genes.";
Cancer Res. 60:6116-6133(2000).
[6]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-923, AND MASS SPECTROMETRY.
TISSUE=Epithelium;
DOI=10.1073/pnas.0404720101; PubMed=15302935 [NCBI, ExPASy, EBI, Israel, Japan]
Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J., Li J., Cohn M.A., Cantley L.C., Gygi S.P.;
"Large-scale characterization of HeLa cell nuclear phosphoproteins.";
Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004).
[7]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-891 AND SER-1025, AND MASS SPECTROMETRY.
TISSUE=Epithelium;
DOI=10.1016/j.cell.2006.09.026; PubMed=17081983 [NCBI, ExPASy, EBI, Israel, Japan]
Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.;
"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.";
Cell 127:635-648(2006).
[8]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1025, AND MASS SPECTROMETRY.
TISSUE=Epithelium;
DOI=10.1038/nbt1240; PubMed=16964243 [NCBI, ExPASy, EBI, Israel, Japan]
Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.;
"A probability-based approach for high-throughput protein phosphorylation analysis and site localization.";
Nat. Biotechnol. 24:1285-1292(2006).
[9]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-360 AND SER-362, AND MASS SPECTROMETRY.
DOI=10.1126/science.1140321; PubMed=17525332 [NCBI, ExPASy, EBI, Israel, Japan]
Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III, Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N., Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.;
"ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.";
Science 316:1160-1166(2007).
[10]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-362; SER-891; SER-1022 AND SER-1025, AND MASS SPECTROMETRY.
DOI=10.1016/j.molcel.2008.07.007; PubMed=18691976 [NCBI, ExPASy, EBI, Israel, Japan]
Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.;
"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.";
Mol. Cell 31:438-448(2008).
[11]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-360; SER-362 AND SER-1025, AND MASS SPECTROMETRY.
DOI=10.1073/pnas.0805139105; PubMed=18669648 [NCBI, ExPASy, EBI, Israel, Japan]
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.;
"A quantitative atlas of mitotic phosphorylation.";
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AF042857; AAC05826.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF069517; AAC21578.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF091264; AAD04160.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
U50839; AAC35207.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
IPI IPI00297723; -.
RefSeq NP_005768.1; -.
UniGene Hs.439480
3D structure databases
ModBase P78332.
PTM databases
PhosphoSite P78332; -.
Organism-specific databases
GeneCards GC03P049952; -.
H-InvDB HIX0003322; -.
HGNC HGNC:9903; RBM6.
GenAtlas RBM6.
MIM 606886; gene. [NCBI / EBI]
PharmGKB PA34268; -.
Gene expression databases
ArrayExpress P78332; -.
Bgee P78332; -.
CleanEx HS_RBM6; -.
GermOnline ENSG00000004534; Homo sapiens.
Ontologies
GO
GO:0005634; Cellular component: nucleus (traceable author statement from ProtInc).
GO:0003677; Molecular function: DNA binding (traceable author statement from ProtInc).
GO:0003723; Molecular function: RNA binding (traceable author statement from ProtInc).
GO:0008270; Molecular function: zinc ion binding (inferred from electronic annotation from InterPro).
GO:0006396; Biological process: RNA processing (traceable author statement from ProtInc).
QuickGo view.
Family and domain databases
InterPro IPR000467; G_patch.
IPR000504; RRM_RNP1.
IPR015880; Znf_C2H2-like.
Graphical view of domain structure.
Pfam PF01585; G-patch; 1.
Pfam graphical view of domain structure.
SMART SM00443; G_patch; 1.
SM00360; RRM; 1.
SM00355; ZnF_C2H2; 1.
SMART graphical view of domain structure.
PROSITE PS50174; G_PATCH; 1.
PS50102; RRM; 1.
PROSITE graphical view of domain structure (profiles).
Proteomic databases
PRIDE P78332; -.
Genome annotation databases
Ensembl ENSG00000004534; Homo sapiens. [Contig view]
GeneID 10180; -.
KEGG hsa:10180; -.
Phylogenomic databases
HOGENOM P78332; -.
HOVERGEN P78332; -.
OMA P78332; SDLDFRD.
Other
NextBio 38538; -.
SOURCE RBM6; Homo sapiens.
ProtoNet P78332.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Disease mutation; Nucleus; Phosphoprotein; Polymorphism; RNA-binding.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom    To Length Description FTId
CHAIN   1   1123  1123     RNA-binding protein 6. PRO_0000081760
DOMAIN   456    536  81     RRM. 
DOMAIN   1051   1097  47     G-patch. 
COMPBIAS   826    829  4     Poly-Glu. 
COMPBIAS   892    895  4     Poly-Pro. 
COMPBIAS   915    921  7     Poly-Glu. 
MOD_RES   360    360        Phosphoserine. 
MOD_RES   362    362        Phosphoserine. 
MOD_RES   891    891        Phosphoserine. 
MOD_RES   923    923        Phosphothreonine. 
MOD_RES   1022   1022        Phosphoserine. 
MOD_RES   1025   1025        Phosphoserine. 
VARIANT   353    353  1     S -> F (in NSCLC). VAR_014226 
VARIANT   721    721  1     N -> T (in dbSNP:rs34707170 [NCBI]). VAR_052216 
CONFLICT   642    642        R -> K (in Ref. 2; AAC21578). 
CONFLICT   710    710        A -> V (in Ref. 1; AAC05826). 
CONFLICT   796    796        T -> S (in Ref. 1; AAC05826). 
Sequence information
Length: 1123 AA [This is the length of the unprocessed precursor] Molecular weight: 128644 Da [This is the MW of the unprocessed precursor] CRC64: 2952ED1BAA839DE4 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MWGDSRPANR TGPFRGSQEE RFAPGWNRDY PPPPLKSHAQ ERHSGNFPGR DSLPFDFQGH 

        70         80         90        100        110        120 
SGPPFANVEE HSFSYGARDG PHGDYRGGEG PGHDFRGGDF SSSDFQSRDS SQLDFRGRDI 

       130        140        150        160        170        180 
HSGDFRDREG PPMDYRGGDG TSMDYRGREA PHMNYRDRDA HAVDFRGRDA PPSDFRGRGT 

       190        200        210        220        230        240 
YDLDFRGRDG SHADFRGRDL SDLDFRAREQ SRSDFRNRDV SDLDFRDKDG TQVDFRGRGS 

       250        260        270        280        290        300 
GTTDLDFRDR DTPHSDFRGR HRSRTDQDFR GREMGSCMEF KDREMPPVDP NILDYIQPST 

       310        320        330        340        350        360 
QDREHSGMNV NRREESTHDH TIERPAFGIQ KGEFEHSETR EGETQGVAFE HESPADFQNS 

       370        380        390        400        410        420 
QSPVQDQDKS QLSGREEQSS DAGLFKEEGG LDFLGRQDTD YRSMEYRDVD HRLPGSQMFG 

       430        440        450        460        470        480 
YGQSKSFPEG KTARDAQRDL QDQDYRTGPS EEKPSRLIRL SGVPEDATKE EILNAFRTPD 

       490        500        510        520        530        540 
GMPVKNLQLK EYNTGYDYGY VCVEFSLLED AIGCMEANQG TLMIQDKEVT LEYVSSLDFW 

       550        560        570        580        590        600 
YCKRCKANIG GHRSSCSFCK NPREVTEAKQ ELITYPQPQK TSIPAPLEKQ PNQPLRPADK 

       610        620        630        640        650        660 
EPEPRKREEG QESRLGHQKR EAERYLPPSR REGPTFRRDR ERESWSGETR QDGESKTIML 

       670        680        690        700        710        720 
KRIYRSTPPE VIVEVLEPYV RLTTANVRII KNRTGPMGHT YGFIDLDSHA EALRVVKILQ 

       730        740        750        760        770        780 
NLDPPFSIDG KMVAVNLATG KRRNDSGDHS DHMHYYQGKK YFRDRRGGGR NSDWSSDTNR 

       790        800        810        820        830        840 
QGQQSSSDCY IYDSATGYYY DPLAGTYYDP NTQQEVYVPQ DPGLPEEEEI KEKKPTSQGK 

       850        860        870        880        890        900 
SSSKKEMSKR DGKEKKDRGV TRFQENASEG KAPAEDVFKK PLPPTVKKEE SPPPPKVVNP 

       910        920        930        940        950        960 
LIGLLGEYGG DSDYEEEEEE EQTPPPQPRT AQPQKREEQT KKENEEDKLT DWNKLACLLC 

       970        980        990       1000       1010       1020 
RRQFPNKEVL IKHQQLSDLH KQNLEIHRKI KQSEQELAYL ERREREGKFK GRGNDRREKL 

      1030       1040       1050       1060       1070       1080 
QSFDSPERKR IKYSRETDSD RKLVDKEDID TSSKGGCVQQ ATGWRKGTGL GYGHPGLASS 

      1090       1100       1110       1120 
EEAEGRMRGP SVGASGRTSK RQSNETYRDA VRRVMFARYK ELD 

P78332 in FASTA format

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