[1]	NUCLEOTIDE SEQUENCE [GENOMIC DNA]. STRAIN=1021; PubMed=9422587 [NCBI, ExPASy, EBI, Israel, Japan] Cheng H.-P., Walker G.C.; "Succinoglycan production by Rhizobium meliloti is regulated through the ExoS-ChvI two-component regulatory system."; J. Bacteriol. 180:20-26(1998).
[2]	NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. STRAIN=1021; DOI=10.1073/pnas.161294398; PubMed=11481430 [NCBI, ExPASy, EBI, Israel, Japan] Capela D., Barloy-Hubler F., Gouzy J., Bothe G., Ampe F., Batut J., Boistard P., Becker A., Boutry M., Cadieu E., Dreano S., Gloux S., Godrie T., Goffeau A., Kahn D., Kiss E., Lelaure V., Masuy D., Pohl T., Portetelle D., Puehler A., Purnelle B., Ramsperger U., Renard C., Thebault P., Vandenbol M., Weidner S., Galibert F.; "Analysis of the chromosome sequence of the legume symbiont Sinorhizobium meliloti strain 1021."; Proc. Natl. Acad. Sci. U.S.A. 98:9877-9882(2001).
[3]	NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-112. STRAIN=SU47 / 1021; PubMed=7559334 [NCBI, ExPASy, EBI, Israel, Japan] Oesteraas M., Stanley J., Finan T.M.; "Identification of Rhizobium-specific intergenic mosaic elements within an essential two-component regulatory system of Rhizobium species."; J. Bacteriol. 177:5485-5494(1995).

Comments

FUNCTION: Member of a two-component regulatory system chvG(exoS)/chvI involved in regulating the production of succinoglycan. Activates chvI by phosphorylation.
CATALYTIC ACTIVITY: ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.
PATHWAY: Glycan metabolism; exopolysaccharide biosynthesis .
SUBUNIT: Homodimer.
SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein.
SIMILARITY: Contains 1 HAMP domain.
SIMILARITY: Contains 1 histidine kinase domain.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

AF027298; AAB96631.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
AL591688; CAC41430.1; ALT_INIT; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
U32941; AAB07686.2; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

NP_384149.1; -.

3D structure databases

ModBase

P72292.

Enzyme and pathway databases

BioCyc

SMEL266834:SMC04446-MON; -.

Ontologies

GO:0016021;	Cellular component: integral to membrane (inferred from electronic annotation from InterPro).
GO:0005886;	Cellular component: plasma membrane (inferred from electronic annotation from UniProtKB-KW).
GO:0005524;	Molecular function: ATP binding (inferred from electronic annotation from InterPro).
GO:0000155;	Molecular function: two-component sensor activity (inferred from electronic annotation from InterPro).
GO:0018106;	Biological process: peptidyl-histidine phosphorylation (inferred from electronic annotation from InterPro).
GO:0000271;	Biological process: polysaccharide biosynthetic process (inferred from electronic annotation from UniProtKB-KW).
GO:0000160;	Biological process: two-component signal transduction system (phosphorelay) (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.

Family and domain databases

InterPro

IPR003594; ATP_bd_ATPase.
IPR004358; Sig_transdc_His_kin-like_C.
IPR003661; Sig_transdc_His_kin_sub1_dim/P.
IPR005467; Sig_transdc_His_kinase_core.
IPR003660; Sig_transdc_His_kinase_HAMP.
Graphical view of domain structure.

Gene3D

G3DSA:3.30.565.10; ATP_bd_ATPase; 1.

Pfam

PF00672; HAMP; 1.
PF02518; HATPase_c; 1.
PF00512; HisKA; 1.
Pfam graphical view of domain structure.

PRINTS

PR00344; BCTRLSENSOR.

SMART

SM00304; HAMP; 1.
SM00387; HATPase_c; 1.
SM00388; HisKA; 1.
SMART graphical view of domain structure.

PROSITE

PS50885; HAMP; 1.
PS50109; HIS_KIN; 1.
PROSITE graphical view of domain structure (profiles).

ProtoNet

P72292.

Genome annotation databases

1231668; -.

AL591688_GR; R00043.

sme:SMc04446; -.

fig|266834.1.peg.1337; -.

Phylogenomic databases

HOGENOM

P72292; -.

Genome annotation databases

CMR

P72292; R00043.

Other

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Cell inner membrane; Cell membrane; Complete proteome; Exopolysaccharide synthesis; Kinase; Membrane; Phosphoprotein; Transferase; Transmembrane; Two-component regulatory system.

Features

Feature table viewer

Feature aligner

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 577`	`577`	`Sensor protein chvG.`	`PRO_0000074721`
`TOPO_DOM`	`1 29`	`29`	`Cytoplasmic (Potential).`
`TRANSMEM`	`30 50`	`21`	`Potential.`
`TOPO_DOM`	`51 260`	`210`	`Periplasmic (Potential).`
`TRANSMEM`	`261 281`	`21`	`Potential.`
`TOPO_DOM`	`282 577`	`296`	`Cytoplasmic (Potential).`
`DOMAIN`	`283 339`	`57`	`HAMP.`
`DOMAIN`	`347 575`	`229`	`Histidine kinase.`
`MOD_RES`	`350 350`		`Phosphohistidine (By similarity).`
`CONFLICT`	`136 136`		`L -> F (in Ref. 1; AAB96631).`
`CONFLICT`	`266 266`		`V -> A (in Ref. 1; AAB96631).`

Sequence information

Length: 577 AA [This is the length of the unprocessed precursor]

Molecular weight: 63721 Da [This is the MW of the unprocessed precursor]

CRC64: BEF2DD4A4F0E2B15 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MRGQRRWAHP FTLIRRLFGN AVFSSLTRRI VFFNLVALVV LVGGIMYLNQ FREGLIDARV 

        70         80         90        100        110        120 
ESLLTQGEII AGAISASASV DTNSITIDPE KLLELQAGES ITPLPSDEDL EFPIIQERVA 

       130        140        150        160        170        180 
PVLRRLISPT RTRARLFDAD ADLLLDSRHL YSGGQVLRFD LPPVDPESPS LADEFGTWFN 

       190        200        210        220        230        240 
RLLQPGDLPL YKEPPGGNGS IYPEVMNALT GVRGAVVRVT EKGELIVSVA VPVQRFRAVL 

       250        260        270        280        290        300 
GVLLLSTQAG DIDKIVHAER LAIIRVFGVA ALVNVILSLL LSSTIANPLR RLSAAAIRVR 

       310        320        330        340        350        360 
RGGAKEREEI PDFSSRQDEI GNLSVALREM TTALYDRIAA IENFAADVSH ELKNPLTSLR 

       370        380        390        400        410        420 
SAVETLPLAR NEESKKRLMD VIQHDVRRLD RLISDISDAS RLDAELARAD AKKVDLEKLL 

       430        440        450        460        470        480 
GDLVEISRQI RGSKKPVLLD FVVDRKDNPR ASFIVSGYEL RIGQIITNLI ENARSFVPEQ 

       490        500        510        520        530        540 
NGRIVVRLTR SRLRCIVYVE DNGPGIQAED IDRIFERFYT DRPEGEDFGQ NSGLGLSISR 

       550        560        570 
QIAEAHGGTL RAENIAGKDG RISGARFVLS LPAGPHP

P72292 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools