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UniProtKB/Swiss-Prot entry P71016


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name BETB_BACSU
Primary accession number P71016
Secondary accession numbers None
Integrated into Swiss-Prot on November 1, 1997
Sequence was last modified on February 1, 1997 (Sequence version 1)
Annotations were last modified on    November 25, 2008 (Entry version 63)
Name and origin of the protein
Protein name Betaine aldehyde dehydrogenase
Synonyms BADH
EC 1.2.1.8
Gene name
Name: gbsA
OrderedLocusNames: BSU31060
From
Bacillus subtilis [TaxID: 1423] [HAMAP proteome]
Taxonomy Bacteria; Firmicutes; Bacillales; Bacillaceae; Bacillus.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND PROTEIN SEQUENCE OF 1-25.
STRAIN=168 / JH642;
PubMed=8752328 [NCBI, ExPASy, EBI, Israel, Japan]
Boch J., Kempf B., Schmid R., Bremer E.;
"Synthesis of the osmoprotectant glycine betaine in Bacillus subtilis: characterization of the gbsAB genes.";
J. Bacteriol. 178:5121-5129(1996).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=168;
DOI=10.1038/36786; PubMed=9384377 [NCBI, ExPASy, EBI, Israel, Japan]
Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S., Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K., Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F., Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D., Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M., Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P., Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K., Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S., Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y., Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G., Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J., Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C., Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S., Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B., Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S., Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M., Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y., Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J., Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A., Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M., Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S., Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E., Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K., Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E., Yoshikawa H., Danchin A.;
"The complete genome sequence of the Gram-positive bacterium Bacillus subtilis.";
Nature 390:249-256(1997).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
U47861; AAC44364.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
Z99119; CAB15084.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR A69629; A69629.
RefSeq NP_390984.1; -.
3D structure databases
HSSP P05091; 1O04. [HSSP ENTRY / PDB]
ModBase P71016.
Enzyme and pathway databases
BioCyc BSUB224308:BSU3101-MON; -.
MetaCyc:MON-8602; -.
Organism-specific databases
SubtiList BG11940; gbsA. [Micado]
Ontologies
GO
GO:0008802; Molecular function: betaine-aldehyde dehydrogenase activity (inferred from electronic annotation from InterPro).
GO:0006578; Biological process: betaine biosynthetic process (inferred from electronic annotation from InterPro).
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR016160; Ald_DHase_CS.
IPR016162; Ald_DHase_N.
IPR015590; Aldehyde_DHase.
IPR011264; Betaine_Ald_DHase.
Graphical view of domain structure.
Gene3D G3DSA:3.40.605.10; Aldehyde_dehydrogenase_N; 1.
PANTHER PTHR11699; Aldehyde_dehyd; 1.
Pfam PF00171; Aldedh; 1.
Pfam graphical view of domain structure.
TIGRFAMs TIGR01804; BADH; 1.
PROSITE PS00070; ALDEHYDE_DEHYDR_CYS; 1.
PS00687; ALDEHYDE_DEHYDR_GLU; 1.
ProtoNet P71016.
Genome annotation databases
GeneID 938829; -.
GenomeReviews AL009126_GR; BSU31060.
KEGG bsu:BSU31060; -.
NMPDR fig|224308.1.peg.3109; -.
Phylogenomic databases
HOGENOM P71016; -.
Genome annotation databases
CMR P71016; BSU31060.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; Direct protein sequencing; NAD; Oxidoreductase.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   490  490     Betaine aldehyde dehydrogenase. PRO_0000056533
NP_BIND   227   232  6     NAD (By similarity). 
ACT_SITE   249   249        By similarity. 
ACT_SITE   283   283        By similarity. 
Sequence information
Length: 490 AA [This is the length of the unprocessed precursor] Molecular weight: 53666 Da [This is the MW of the unprocessed precursor] CRC64: 67F44C5818B4AD55 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MSQTLFIDGE WISAEKEQIR SIINPFNQEE IATVSEGGRE DAIKAIAAAR RAFDKGEWSS 

        70         80         90        100        110        120 
LSGLERGKIV LKIAELIRRD LEELAELESL DTGKTLEESK ADMDDIANVF QYYAGLADKD 

       130        140        150        160        170        180 
GGEIISSPIP DSESKIIREP IGVCGQITPW NYPLLQASWK IAPALAAGNT IVMKPSEITP 

       190        200        210        220        230        240 
LTTIKVFKLM EEAGVPKGVA NLVLGPGATV GDELAVNKDV DLISFTGGIE TGKKIMRAAS 

       250        260        270        280        290        300 
GNVKKIALEL GGKNPNIVFK DADLEVAVDQ ALNAVFFHAG QVCSAGSRLL VEDAIHDQFL 

       310        320        330        340        350        360 
AELVKRAKRI KLGNGFHAET ESGPLISAEH RAKVEKYVEI GIEEGAKLET GGKRPEDPEL 

       370        380        390        400        410        420 
QNGFFYEPTI FSNCNSDMRI VQEEVFGPVL TVETFSSEEE VIELANDTIY GLAGAVWSKD 

       430        440        450        460        470        480 
IEKCERVAAR LRMGTVWIND FHPYFAQAPW GGYKQSGFGR ELGKIGLEEY TEVKHVYRNT 

       490 
KPAAVNWFNS 

P71016 in FASTA format

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