ID   6PGD_ACTAC              Reviewed;         484 AA.
AC   P70718;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1997, sequence version 1.
DT   04-NOV-2008, entry version 48.
DE   RecName: Full=6-phosphogluconate dehydrogenase, decarboxylating;
DE            EC=1.1.1.44;
GN   Name=gnd;
OS   Actinobacillus actinomycetemcomitans (Haemophilus
OS   actinomycetemcomitans).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Aggregatibacter.
OX   NCBI_TaxID=714;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 43718 / FDC Y4 / Serotype b;
RX   MEDLINE=97148607; PubMed=9020051; DOI=10.1006/bbrc.1996.5917;
RA   Yoshida Y., Nakano Y., Yamashita Y., Koga T.;
RT   "The gnd gene encoding a novel 6-phosphogluconate dehydrogenase and
RT   its adjacent region of Actinobacillus actinomycetemcomitans
RT   chromosomal DNA.";
RL   Biochem. Biophys. Res. Commun. 230:220-225(1997).
CC   -!- CATALYTIC ACTIVITY: 6-phospho-D-gluconate + NADP(+) = D-ribulose
CC       5-phosphate + CO(2) + NADPH.
CC   -!- PATHWAY: Carbohydrate degradation; pentose phosphate pathway; D-
CC       ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage):
CC       step 3/3.
CC   -!- SIMILARITY: Belongs to the 6-phosphogluconate dehydrogenase
CC       family.
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DR   EMBL; D88189; BAA13558.1; -; Genomic_DNA.
DR   PIR; JC5282; JC5282.
DR   HSSP; P00349; 2PGD.
DR   GO; GO:0019521; P:D-gluconate metabolic process; IEA:UniProtKB-KW.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   InterPro; IPR006183; 6-phosphogluconate_DHase.
DR   InterPro; IPR006114; 6PGDH_C.
DR   InterPro; IPR006113; 6PGDH_decarbox.
DR   InterPro; IPR006115; 6PGDH_NAD-bd.
DR   InterPro; IPR006184; 6PGdom_BS.
DR   InterPro; IPR013328; DHase_multihelical.
DR   InterPro; IPR012284; Fibritin/6PGD_C-extension.
DR   InterPro; IPR016040; NAD(P)-bd.
DR   Gene3D; G3DSA:1.20.5.320; Fibritin/6PGD_C-extension; 1.
DR   Gene3D; G3DSA:3.40.50.720; NAD(P)-bd; 1.
DR   Gene3D; G3DSA:1.10.1040.10; Opine_DH; 1.
DR   Pfam; PF00393; 6PGD; 1.
DR   Pfam; PF03446; NAD_binding_2; 1.
DR   PRINTS; PR00076; 6PGDHDRGNASE.
DR   TIGRFAMs; TIGR00873; gnd; 1.
DR   PROSITE; PS00461; 6PGD; 1.
PE   3: Inferred from homology;
KW   Gluconate utilization; NADP; Oxidoreductase; Pentose shunt.
FT   CHAIN         1    484       6-phosphogluconate dehydrogenase,
FT                                decarboxylating.
FT                                /FTId=PRO_0000090024.
SQ   SEQUENCE   484 AA;  53289 MW;  F7BD0B2EA3BF624D CRC64;
     MSVKGDIGVI GLAVMGQNLI LNMNDHGFKV VAYNRTTSKV DEFLEGAAKG TNIIGAYSLE
     DLANKLEKPR KVMLMVRAGE VVDHFIDALL PHLEAGDIII DGGNSNYPDT NRRVAALREK
     GIRFIGTGVS GGEEGARHGP SIMPGGNEEA WQFVKPVLQA ISAKTEQGEP CCDWVGKDGA
     GHFVKMVHNG IEYGDMQLIC EAYQFLKEGV GLSDDELQAT FNEWRNTELD SYLIDITADI
     LGYKDADGSR LVDKVLDTAG QKGTGKWTGI NALDFGIPLT LITESVFARC VSAFKDQRVA
     ASKLFHKTIG KVEGDKKVWI EAVRKALLAS KIISYAQGFM LIREASEHFN WNINYGNTAL
     LWREGCIIRS RFLGNIRDAY EANPDLIFLG SDSYFKGILE NAMSDWRKVV AKSIEVGIPM
     PCMASAITFL DGYTSARLPA NLLQAQRDYF GAHTYERTDK PRGEFFHTNW TGRGGNTAST
     TYDV
//