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UniProtKB/Swiss-Prot entry P70619

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name GSHR_RAT
Primary accession number P70619
Secondary accession numbers None
Integrated into Swiss-Prot on July 5, 2004
Sequence was last modified on July 5, 2004 (Sequence version 2)
Annotations were last modified on    November 25, 2008 (Entry version 53)
Name and origin of the protein
Protein name Glutathione reductase [Fragment]
Synonyms GRase
GR
EC 1.8.1.7
Gene name
Name: Gsr
From
Rattus norvegicus (Rat) [TaxID: 10116] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus.
Protein existence 2: Evidence at transcript level;
References
[1]
 NUCLEOTIDE SEQUENCE [MRNA].
Hou W.M., Cheplinsky A.B.;
Submitted (OCT-1996) to the EMBL/GenBank/DDBJ databases.
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
U73174; AAB18132.1; ALT_FRAME; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_446358.1; -.
UniGene Rn.19721
3D structure databases
HSSP P00390; 1ALG. [HSSP ENTRY / PDB]
SMR P70619; 1-424.
ModBase P70619.
Organism-specific databases
RGD 621747; Gsr.
Gene expression databases
ArrayExpress P70619; -.
GermOnline ENSRNOG00000014915; Rattus norvegicus.
Ontologies
GO
GO:0009055; Molecular function: electron carrier activity (inferred from electronic annotation from InterPro).
GO:0050660; Molecular function: FAD binding (inferred from electronic annotation from InterPro).
GO:0004362; Molecular function: glutathione-disulfide reductase activity (inferred from electronic annotation from InterPro).
GO:0050661; Molecular function: NADP binding (inferred from electronic annotation from InterPro).
GO:0045454; Biological process: cell redox homeostasis (inferred from electronic annotation from InterPro).
GO:0006749; Biological process: glutathione metabolic process (inferred from electronic annotation from InterPro).
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR013027; FAD_pyr_nucl-diS_OxRdtase.
IPR006322; Glut_reduct_1.
IPR000815; Hg_reductase.
IPR001100; Pyr_nuc-diS_OxRdtase.
IPR004099; Pyr_nucl-diS_OxRdtase_dimer.
IPR012999; Pyr_OxRdtase_I_AS.
IPR001327; Pyr_OxRdtase_NAD_bd.
Graphical view of domain structure.
Gene3D G3DSA:3.30.390.30; Pyr_redox_dim; 1.
Pfam PF00070; Pyr_redox; 1.
PF07992; Pyr_redox_2; 1.
PF02852; Pyr_redox_dim; 1.
Pfam graphical view of domain structure.
PRINTS PR00368; FADPNR.
PR00945; HGRDTASE.
PR00411; PNDRDTASEI.
ProDom PD000139; FAD_pyr_redox; 1.
[Domain structure / List of seq. sharing at least 1 domain]
TIGRFAMs TIGR01421; gluta_reduc_1; 1.
PROSITE PS00076; PYRIDINE_REDOX_1; PARTIAL.
ProtoNet P70619.
Genome annotation databases
Ensembl ENSRNOG00000014915; Rattus norvegicus. [Contig view]
GeneID 116686; -.
KEGG rno:116686; -.
Phylogenomic databases
HOVERGEN P70619; -.
Other
NextBio 619544; -.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
FAD; Flavoprotein; NADP; Oxidoreductase; Redox-active center.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   <1   424  >424     Glutathione reductase. PRO_0000067957
ACT_SITE   413   413        Proton acceptor (By similarity). 
DISULFID   32    32        Interchain (By similarity). 
NON_TER   1     1         
Sequence information
Length: 424 AA [This is the length of the partial sequence of the unprocessed precursor] Molecular weight: 46301 Da [This is the MW of the partial sequence of the unprocessed precursor] CRC64: 0714FF531F90BEBA [This is a checksum on the sequence] 
        10         20         30         40         50         60 
VNVGCVPKKV MWNTAVHSEF IHDHVDYGFQ NCKSKFNWHV IKEKRDAYVS RLNNIYQNNL 

        70         80         90        100        110        120 
TKSHIEVIHG YATFRDGPQP TAEVNGKKFT APHILIATGG VPTVPHENQI PGASLGITSD 

       130        140        150        160        170        180 
GFFQLEDLPS RSVIVGAGYI AVEIAGILSA LGSKTSLMIR HDKVLRSFDS LISSNCTEEL 

       190        200        210        220        230        240 
ENAGGVEVLT VKKFSQVKEV KKTSSGLELH VVTALPGRKP TVTTIPDVDC LLWAIGRDPN 

       250        260        270        280        290        300 
SKGLNLNKLG IQTDDKGHIL VDEFQNTNVK GVYAVGDVCG KALLTPVAIA AGRKLAHRLF 

       310        320        330        340        350        360 
EGKEDSRLDY DNIPTVVFSH PPIGTVGLTE DEAVHKYGKD NVKIYSTAFT PMYHAVTTRK 

       370        380        390        400        410        420 
TKCVMKMVCA NKEEKVVGIH MQGIGCDEML QGFAVAVKMG ATKADFDNRV AIHPTSSEEL 


VTLR
P70619 in FASTA format

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