[1]
|
NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, AND MUTAGENESIS OF THR-194 AND LYS-222.
STRAIN=Sprague-Dawley;
TISSUE=Brain;
DOI=10.1006/mcne.1996.0034; PubMed=8875430 [NCBI, ExPASy, EBI, Israel, Japan]
Tsuchida K.,
Sawchenko P.E.,
Nishikawa S.,
Vale W.W.;
"Molecular cloning of a novel type I receptor serine/threonine kinase for the TGF beta superfamily from rat brain.";
Mol. Cell. Neurosci. 7:467-478(1996).
|
[2]
|
NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
TISSUE=Brain;
DOI=10.1074/jbc.271.48.30603; PubMed=8940033 [NCBI, ExPASy, EBI, Israel, Japan]
Ryden M.,
Imamura T.,
Joernvall H.,
Belluardo N.,
Neveu I.,
Trupp M.,
Okadome T.,
ten Dijke P.,
Ibanez C.F.;
"A novel type I receptor serine-threonine kinase predominantly expressed in the adult central nervous system.";
J. Biol. Chem. 271:30603-30609(1996).
|
[3]
|
PROTEIN SEQUENCE OF 139-159, FUNCTION, TISSUE SPECIFICITY, SUBCELLULAR LOCATION, AND INTERACTION WITH ACVR2A; ACTIVIN AB AND B.
DOI=10.1016/j.mce.2004.03.009; PubMed=15196700 [NCBI, ExPASy, EBI, Israel, Japan]
Tsuchida K.,
Nakatani M.,
Yamakawa N.,
Hashimoto O.,
Hasegawa Y.,
Sugino H.;
"Activin isoforms signal through type I receptor serine/threonine kinase ALK7.";
Mol. Cell. Endocrinol. 220:59-65(2004).
|
[4]
|
FUNCTION, TISSUE SPECIFICITY, AND MUTAGENESIS OF THR-194.
DOI=10.1006/bbrc.1998.0118; PubMed=9920806 [NCBI, ExPASy, EBI, Israel, Japan]
Watanabe R.,
Yamada Y.,
Ihara Y.,
Someya Y.,
Kubota A.,
Kagimoto S.,
Kuroe A.,
Iwakura T.,
Shen Z.-P.,
Inada A.,
Adachi T.,
Ban N.,
Miyawaki K.,
Sunaga Y.,
Tsuda K.,
Seino Y.;
"The MH1 domains of smad2 and smad3 are involved in the regulation of the ALK7 signals.";
Biochem. Biophys. Res. Commun. 254:707-712(1999).
|
[5]
|
FUNCTION, AND TISSUE SPECIFICITY.
DOI=10.1074/jbc.M005200200; PubMed=11084022 [NCBI, ExPASy, EBI, Israel, Japan]
Joernvall H.,
Blokzijl A.,
ten Dijke P.,
Ibanez C.F.;
"The orphan receptor serine/threonine kinase ALK7 signals arrest of proliferation and morphological differentiation in a neuronal cell line.";
J. Biol. Chem. 276:5140-5146(2001).
|
|
- FUNCTION: Serine/threonine protein kinase which forms a receptor complex on ligand binding. The receptor complex consisting of 2 type II and 2 type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators, SMAD2 and SMAD3. Receptor for activin AB, activin B and NODAL. Plays a role in cell differentiation, growth arrest and apoptosis.
- CATALYTIC ACTIVITY: ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.
- COFACTOR: Magnesium or manganese.
- SUBUNIT: Binds the type 2 receptor protein ACVR2A.
- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
- TISSUE SPECIFICITY: Expressed in brain, kidney, lung, liver, testis, ovary, adrenal gland, heart, prostate, gastrointestinal tract, and spleen. Distributed throughout both adult and embryonic central nervous system and pancreatic islet cells.
- SIMILARITY: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
- SIMILARITY: Contains 1 GS domain.
- SIMILARITY: Contains 1 protein kinase domain.
|
ExPASy Home page
SIB Switzerland
