[1]
|
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS PLD1A AND PLD1B).
PubMed=9533024 [NCBI, ExPASy, EBI, Israel, Japan]
Nakashima S.,
Matsuda Y.,
Akao Y.,
Yoshimura S.,
Sakai H.,
Hayakawa K.,
Andoh M.,
Nozawa Y.;
"Molecular cloning and chromosome mapping of rat phospholipase D genes, Pld1a, Pld1b and Pld2.";
Cytogenet. Cell Genet. 79:109-113(1997).
|
[2]
|
NUCLEOTIDE SEQUENCE [MRNA] OF 467-673 (ISOFORMS PLD1A AND PLD1B).
TISSUE=Glial cell;
DOI=10.1006/bbrc.1996.1201; PubMed=8753790 [NCBI, ExPASy, EBI, Israel, Japan]
Yoshimura S.,
Nakashima S.,
Ohguchi K.,
Sakai H.,
Shinoda J.,
Sakai N.,
Nozawa Y.;
"Differential mRNA expression of phospholipase D (PLD) isozymes during cAMP-induced differentiation in C6 glioma cells.";
Biochem. Biophys. Res. Commun. 225:494-499(1996).
|
[3]
|
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM PLD1B).
DOI=10.1074/jbc.272.46.29263; PubMed=9361006 [NCBI, ExPASy, EBI, Israel, Japan]
Park S.K.,
Provost J.J.,
Bae C.D.,
Ho W.T.,
Exton J.H.;
"Cloning and characterization of phospholipase D from rat brain.";
J. Biol. Chem. 272:29263-29271(1997).
|
[4]
|
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS PLD1A AND PLD1B).
PubMed=9445394 [NCBI, ExPASy, EBI, Israel, Japan]
Katayama K.,
Kodaki T.,
Nagamachi Y.,
Yamashita S.;
"Cloning, differential regulation and tissue distribution of alternatively spliced isoforms of ADP-ribosylation-factor-dependent phospholipase D from rat liver.";
Biochem. J. 329:647-652(1998).
|
[5]
|
NUCLEOTIDE SEQUENCE [MRNA] OF 1-511.
Lassegue B.,
Alexander R.W.,
Griendling K.;
"Molecular cloning of a cDNA homologous to a phospholipase D1 segment.";
Submitted (FEB-1997) to the EMBL/GenBank/DDBJ databases.
|
[6]
|
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM PLD1C).
TISSUE=Lung;
Park S.K.,
Exton J.H.;
"Phospholipase D not having transphosphatidylation reaction.";
Submitted (AUG-1997) to the EMBL/GenBank/DDBJ databases.
|
[7]
|
PALMITOYLATION AT CYS-240 AND CYS-241, MUTAGENESIS OF CYS-240 AND CYS-241, AND PHOSPHORYLATION.
DOI=10.1074/jbc.M009425200; PubMed=11121416 [NCBI, ExPASy, EBI, Israel, Japan]
Xie Z.,
Ho W.T.,
Exton J.H.;
"Requirements and effects of palmitoylation of rat PLD1.";
J. Biol. Chem. 276:9383-9391(2001).
|
|
- FUNCTION: Implicated as a critical step in numerous cellular pathways, including signal transduction, membrane trafficking, and the regulation of mitosis. May be involved in the regulation of perinuclear intravesicular membrane traffic (By similarity).
- CATALYTIC ACTIVITY: A phosphatidylcholine + H2O = choline + a phosphatidate.
- ENZYME REGULATION: Stimulated by phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate, activated by the phosphokinase C-alpha, by the ADP-ribosylation factor-1 (ARF-1), and to a lesser extent by GTP-binding proteins: RHO A, RAC-1 and CDC42 (By similarity).
- SUBUNIT: Interacts with PIP5K1A (By similarity).
- SUBCELLULAR LOCATION: Cytoplasm, perinuclear region (By similarity). Endoplasmic reticulum membrane; Lipid-anchor (By similarity). Golgi apparatus membrane; Lipid-anchor (By similarity). Late endosome membrane; Lipid-anchor (By similarity). Note=Membrane-associated.
- ALTERNATIVE PRODUCTS:
3 named isoforms [FASTA] produced by alternative splicing.
|
| Name | PLD1B |
| Isoform ID | P70496-2 |
| Features which should be applied to build the isoform sequence: VSP_005024. |
|
| |
- PTM: Phosphorylated on serine and threonine residues.
- PTM: It is uncertain whether palmitoylation is on Cys-240 and/or Cys-241. Palmitoylation is required prior to phosphorylation.
- SIMILARITY: Belongs to the phospholipase D family.
- SIMILARITY: Contains 1 PH domain.
- SIMILARITY: Contains 2 PLD phosphodiesterase domains.
- SIMILARITY: Contains 1 PX (phox homology) domain.
|
ExPASy Home page
SIB Switzerland
