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UniProtKB/Swiss-Prot entry P70083

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name AT2A1_MAKNI
Primary accession number P70083
Secondary accession numbers P70084 Q91100 Q92082
Integrated into Swiss-Prot on December 1, 2000
Sequence was last modified on December 1, 2000 (Sequence version 2)
Annotations were last modified on    September 2, 2008 (Entry version 74)
Name and origin of the protein
Protein name Sarcoplasmic/endoplasmic reticulum calcium ATPase 1
Synonyms SERCA1
EC 3.6.3.8
Calcium pump 1
Calcium-transporting ATPase sarcoplasmic reticulum type, fast twitch skeletal muscle isoform
SR Ca(2+)-ATPase 1
Endoplasmic reticulum class 1/2 Ca(2+) ATPase
Gene name
Name: atp2a1
From
Makaira nigricans (Blue marlin) [TaxID: 13604] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Euteleostei; Neoteleostei; Acanthomorpha; Acanthopterygii; Percomorpha; Perciformes; Scombroidei; Xiphiidae; Makaira.
Protein existence 2: Evidence at transcript level;
References
[1]
 NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS SERCA1A AND SERCA1B).
TISSUE=Extraocular muscle;
DOI=10.1016/S0305-0491(00)00256-X; PubMed=11079376 [NCBI, ExPASy, EBI, Israel, Japan]
Londraville R.L., Cramer T.D., Franck J.P.C.F., Tullis A., Block B.A.;
"Cloning of a neonatal calcium atpase isoform (SERCA 1B) from extraocular muscle of adult blue marlin (Makaira nigricans).";
Comp. Biochem. Physiol. 127B:223-233(2000).
[2]
 NUCLEOTIDE SEQUENCE [MRNA] OF 349-438 AND 448-578.
TISSUE=Heating tissue, and Muscle;
PubMed=8760229 [NCBI, ExPASy, EBI, Israel, Japan]
Tullis A., Block B.A.;
"Expression of sarcoplasmic reticulum Ca(2+)-ATPase isoforms in marlin and swordfish muscle and heater cells.";
Am. J. Physiol. 271:R262-R275(1996).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
U65229; AAB08098.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
U65228; AAB08097.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
U58321; AAB17073.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
U58327; AAB17075.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
3D structure databases
HSSP P04191; 1EUL. [HSSP ENTRY / PDB]
SMR P70083; 1-990.
ModBase P70083.
Ontologies
GO
GO:0005509; Molecular function: calcium ion binding (inferred from sequence or structural similarity from UniProtKB).
GO:0005388; Molecular function: calcium-transporting ATPase activity (inferred from sequence or structural similarity from UniProtKB).
GO:0005515; Molecular function: protein binding (inferred from sequence or structural similarity from UniProtKB).
GO:0006816; Biological process: calcium ion transport (inferred from sequence or structural similarity from UniProtKB).
GO:0031448; Biological process: positive regulation of fast-twitch skeletal muscle fiber contraction (inferred from sequence or structural similarity from UniProtKB).
QuickGo view.
Family and domain databases
InterPro IPR001757; ATPase_P.
IPR006068; ATPase_P_cat_C.
IPR004014; ATPase_P_cat_N.
IPR005782; Calcium_ATPase.
IPR005834; Dehalogen-like_hydro.
IPR008250; E1-E2_ATPase_reg.
Graphical view of domain structure.
PANTHER PTHR11939; ATPase_P; 1.
Pfam PF00689; Cation_ATPase_C; 1.
PF00690; Cation_ATPase_N; 1.
PF00122; E1-E2_ATPase; 1.
PF00702; Hydrolase; 1.
Pfam graphical view of domain structure.
PRINTS PR00119; CATATPASE.
TIGRFAMs TIGR01116; ATPase-IIA1_Ca; 1.
TIGR01494; ATPase_P-type; 4.
PROSITE PS00154; ATPASE_E1_E2; 1.
BLOCKS P70083.
ProtoNet P70083.
Phylogenomic databases
HOVERGEN P70083; -.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Alternative splicing; ATP-binding; Calcium; Calcium transport; Endoplasmic reticulum; Hydrolase; Ion transport; Magnesium; Membrane; Metal-binding; Nucleotide-binding; Phosphoprotein; Sarcoplasmic reticulum; Transmembrane; Transport.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   996  996     Sarcoplasmic/endoplasmic reticulum calcium ATPase 1. PRO_0000046192
TOPO_DOM   1    48  48     Cytoplasmic (By similarity). 
TRANSMEM   49    69  21     1 (By similarity). 
TOPO_DOM   70    89  20     Lumenal (By similarity). 
TRANSMEM   90   110  21     2 (By similarity). 
TOPO_DOM   111   253  143     Cytoplasmic (By similarity). 
TRANSMEM   254   273  20     3 (By similarity). 
TOPO_DOM   274   295  22     Lumenal (By similarity). 
TRANSMEM   296   313  18     4 (By similarity). 
TOPO_DOM   314   754  441     Cytoplasmic (By similarity). 
TRANSMEM   755   774  20     5 (By similarity). 
TOPO_DOM   775   784  10     Lumenal (By similarity). 
TRANSMEM   785   805  21     6 (By similarity). 
TOPO_DOM   806   825  20     Cytoplasmic (By similarity). 
TRANSMEM   826   848  23     7 (By similarity). 
TOPO_DOM   849   894  46     Lumenal (By similarity). 
TRANSMEM   895   914  20     8 (By similarity). 
TOPO_DOM   915   927  13     Cytoplasmic (By similarity). 
TRANSMEM   928   946  19     9 (By similarity). 
TOPO_DOM   947   961  15     Lumenal (By similarity). 
TRANSMEM   962   982  21     10 (By similarity). 
TOPO_DOM   983   996  14     Cytoplasmic (By similarity). 
REGION   370   400  31     Interacts with phospholamban 1 (By similarity). 
REGION   785   805  21     Interacts with phospholamban 2 (By similarity). 
ACT_SITE   351   351        4-aspartylphosphate intermediate (By similarity). 
METAL   304   304        Calcium 2; via carbonyl oxygen (By similarity). 
METAL   305   305        Calcium 2; via carbonyl oxygen (By similarity). 
METAL   307   307        Calcium 2; via carbonyl oxygen (By similarity). 
METAL   309   309        Calcium 2 (By similarity). 
METAL   700   700        Magnesium (By similarity). 
METAL   704   704        Magnesium (By similarity). 
METAL   765   765        Calcium 1 (By similarity). 
METAL   768   768        Calcium 1 (By similarity). 
METAL   793   793        Calcium 2 (By similarity). 
METAL   796   796        Calcium 1 (By similarity). 
METAL   797   797        Calcium 1 (By similarity). 
METAL   797   797        Calcium 2 (By similarity). 
METAL   905   905        Calcium 1 (By similarity). 
DISULFID   873   885        By similarity. 
VAR_SEQ   991   996        TGKEVK -> K (in isoform SERCA1A). VSP_000357
CONFLICT   577   577        D -> Y (in Ref. 1; AAB08097). 
Sequence information
Length: 996 AA [This is the length of the unprocessed precursor] Molecular weight: 109247 Da [This is the MW of the unprocessed precursor] CRC64: 821032E8D5F36392 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MENAHTKSPA ECLSYFGVNE HTGLSPDQFK KNLDKFGYNE LPAEEGKSIW DLIVEQFEDL 

        70         80         90        100        110        120 
LVRILLLAAC ISFVLAWFEE GEETITAFVE PFVILLILIA NAIVGVWQER NAEDAIEALK 

       130        140        150        160        170        180 
EYEPEMGKVY RSDRKSVQRI KAREIVPGDI VEVSVGDKVP ADIRIVSIKS TTLRVDQSIL 

       190        200        210        220        230        240 
TGESVSVIKH TESVPDPRAV NQDKKNMLFS GTNIAAGKAI GVAIATGVST EIGKIRDQMA 

       250        260        270        280        290        300 
ATEQEKTPLQ AKLDEFGEQL SKVISLICVA VWAINIGHFN DPVHGGSWIR GAVYYFKIAV 

       310        320        330        340        350        360 
ALAVAAIPEG LPAVITTCLA LGTRRMAKKN AIVRSLPSVE TLGCTSVICS DKTGTLTTNQ 

       370        380        390        400        410        420 
MCVTKMFIVK SVDGDHVDLN AFDISGSKYT PEGEVSHGGS KTNCSAYDGL VELATICALC 

       430        440        450        460        470        480 
NDSSLDYNES KKIYEKVGEA TETALCCLVE KMNVFNSNVK NLSRIERANA CCTVIKQLMK 

       490        500        510        520        530        540 
KNFTLEFSRD RKSMSVYCTP AKGDGGAKMF VKGAPEGVID RCAYVRVGTT RVPLTSAIKE 

       550        560        570        580        590        600 
KIMAVIRDWG TGRDTLRCLA LATRDTPLKV EEMNLEDSTK FADYETDMTF VGCVGMLDPP 

       610        620        630        640        650        660 
RKEVTGSIEL CRDAGIRVIM ITGDNKGTAI AICRRIGIFK EDEDVSNKAY TGREFDDLPS 

       670        680        690        700        710        720 
QDQAEAVRRA CCFARVEPSH KSKIVEFLQG NDDITAMTGD GVNDAPALKK AEIGIAMGSG 

       730        740        750        760        770        780 
TAVAKSASEM VLADDNFSSI VAAVEEGRAI YNNMKQFIRY LISSNVGEVV CIFLTAALGL 

       790        800        810        820        830        840 
PEALIPVQLL WVNLVTDGLP ATALGFNPPD LDIMGKPPRS PKEPLISGWL FFRYMAIGGY 

       850        860        870        880        890        900 
VGAATVGGAA WWFLYDSTGP AVTYYQLSHF MQCHNHNEDF TGVDCDIFEA SPPMTMALSV 

       910        920        930        940        950        960 
LVTIEMCNAL NSLSENQSLI RMPPWSNLWL MAAMTLSMSL HFMIIYVDPL PMIFKLTHLT 

       970        980        990 
FDQWLMVFKL SFPVILIDEV LKFFARNYIE TGKEVK
P70083 in FASTA format

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