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UniProtKB/Swiss-Prot entry P70080

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name TPH1_CHICK
Primary accession number P70080
Secondary accession numbers None
Integrated into Swiss-Prot on July 15, 1998
Sequence was last modified on February 1, 1997 (Sequence version 1)
Annotations were last modified on    November 25, 2008 (Entry version 58)
Name and origin of the protein
Protein name Tryptophan 5-hydroxylase 1
Synonyms EC 1.14.16.4
Tryptophan 5-monooxygenase 1
Gene name
Name: TPH1
Synonyms: TPH
From
Gallus gallus (Chicken) [TaxID: 9031] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galliformes; Phasianidae; Phasianinae; Gallus.
Protein existence 2: Evidence at transcript level;
References
[1]
 NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=White leghorn;
TISSUE=Pineal gland;
DOI=10.1016/S0169-328X(96)00104-0; PubMed=8915576 [NCBI, ExPASy, EBI, Israel, Japan]
Florez J.C., Seidenman K.J., Barrett R.K., Sangoram A.M., Takahashi J.S.;
"Molecular cloning of chick pineal tryptophan hydroxylase and circadian oscillation of its mRNA levels.";
Brain Res. Mol. Brain Res. 42:25-30(1996).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
U26428; AAC60036.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_990287.1; -.
UniGene Gga.43354
3D structure databases
HSSP P17752; 1MLW. [HSSP ENTRY / PDB]
SMR P70080; 105-394.
ModBase P70080.
Ontologies
GO
GO:0016597; Molecular function: amino acid binding (inferred from electronic annotation from InterPro).
GO:0005506; Molecular function: iron ion binding (inferred from electronic annotation from InterPro).
GO:0004510; Molecular function: tryptophan 5-monooxygenase activity (inferred from electronic annotation from InterPro).
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
GO:0006587; Biological process: serotonin biosynthetic process from tryptophan (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR001273; Aaa_hydroxylase.
IPR002912; ACT_bd.
IPR005963; Tyr_5_mOase.
Graphical view of domain structure.
Gene3D G3DSA:1.10.800.10; Aaa_hydroxylase; 1.
PANTHER PTHR11473; Aaa_hydroxylase; 1.
Pfam PF01842; ACT; 1.
PF00351; Biopterin_H; 1.
Pfam graphical view of domain structure.
PRINTS PR00372; FYWHYDRXLASE.
ProDom PD002559; Aaa_hydroxylase; 1.
[Domain structure / List of seq. sharing at least 1 domain]
TIGRFAMs TIGR01270; Trp_5_monoox; 1.
PROSITE PS00367; BIOPTERIN_HYDROXYL; 1.
ProtoNet P70080.
Genome annotation databases
Ensembl ENSGALG00000006236; Gallus gallus. [Contig view]
GeneID 395799; -.
KEGG gga:395799; -.
Phylogenomic databases
HOGENOM P70080; -.
HOVERGEN P70080; -.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Iron; Metal-binding; Monooxygenase; Oxidoreductase; Phosphoprotein; Serotonin biosynthesis.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   445  445     Tryptophan 5-hydroxylase 1. PRO_0000205572
DOMAIN   18    92  75     ACT. 
METAL   273   273        Iron (By similarity). 
METAL   278   278        Iron (By similarity). 
METAL   318   318        Iron (By similarity). 
MOD_RES   58    58        Phosphoserine; by PKA (Potential). 
Sequence information
Length: 445 AA [This is the length of the unprocessed precursor] Molecular weight: 51139 Da [This is the MW of the unprocessed precursor] CRC64: FF0041D7C4B159F6 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MIEDNKENKD HAPERGRTAI IFSLKNEVGG LVKALKLFQE KHVNLVHIES RKSKRRNSEF 

        70         80         90        100        110        120 
EIFVDCDSNR EQLNEIFQLL KSHVSIVSMN PTEHFNVQED GDMENIPWYP KKISDLDKCA 

       130        140        150        160        170        180 
NRVLMYGSDL DADHPGFKDN VYRKRRKYFA DLAMNYKHGD PIPEIEFTEE EIKTWGTVYR 

       190        200        210        220        230        240 
ELNKLYPTHA CREYLKNLPL LTKYCGYRED NIPQLEDVSR FLKERTGFTI RPVAGYLSPR 

       250        260        270        280        290        300 
DFLAGLAFRV FHCTQYVRHS SDPLYTPEPD TCHELLGHVP LLAEPSFAQF SQEIGLASLG 

       310        320        330        340        350        360 
ASDEAVQKLA TCYFFTVEFG LCKQEGQLRV YGAGLLSSIS ELKHSLSGSA KVKPFDPKVT 

       370        380        390        400        410        420 
CKQECLITTF QEVYFVSESF EEAKEKMREF AKTIKRPFGV KYNPYTQSVQ ILKDTKSIAS 

       430        440 
VVNELRHELD IVSDALSKMG KQLEV
P70080 in FASTA format

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