|
|
|
|
|
|
[1]
|
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=White leghorn;
TISSUE=Brain, and Liver;
DOI=10.1074/jbc.271.20.11920; PubMed=8662608 [NCBI, ExPASy, EBI, Israel, Japan]
Muehlebach S.M.,
Wirz T.,
Braendle U.,
Perriard J.-C.;
"Evolution of the creative kinases. The chicken acidic type mitochondrial creatine kinase gene as the first nonmammalian gene.";
J. Biol. Chem. 271:11920-11929(1996).
|
[2]
|
PROTEIN SEQUENCE OF 40-68.
TISSUE=Brain;
PubMed=2831887 [NCBI, ExPASy, EBI, Israel, Japan]
Hossle J.P.,
Schlegel J.,
Wegmann G.,
Wyss M.,
Boehlen P.,
Eppenberger H.M.,
Wallimann T.,
Perriard J.-C.;
"Distinct tissue specific mitochondrial creatine kinases from chicken brain and striated muscle with a conserved CK framework.";
Biochem. Biophys. Res. Commun. 151:408-416(1988).
|
|
|
|
- FUNCTION: Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa.
- CATALYTIC ACTIVITY: ATP + creatine = ADP + phosphocreatine.
- SUBUNIT: Exists as an octamer composed of four MTCK homodimers (By similarity).
- SUBCELLULAR LOCATION: Mitochondrion inner membrane; Peripheral membrane protein; Intermembrane side.
- TISSUE SPECIFICITY: Highly expressed in brain and gut, weakly in testis. Also found in cell bodies of neural cells of the gray matter.
- MISCELLANEOUS: Mitochondrial creatine kinase binds cardiolipin (By similarity).
- SIMILARITY: Belongs to the ATP:guanido phosphotransferase family.
|
|
|
|
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms.
Distributed under the Creative Commons Attribution-NoDerivs License.
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| Length: 417 AA [This is the length of the unprocessed precursor] |
Molecular weight: 47104 Da [This is the MW of the unprocessed precursor] |
CRC64: ED9B982764153D2C [This is a checksum on the sequence] |
|
10 20 30 40 50 60
MASTFARALS ARRSAGLLAM VGAGSLAAGF LLARDTVSAG ERQRRRYPPS AEYPDLRKHN
70 80 90 100 110 120
NCMASNLTPA IYARLCDKAT PNGWTLDQCI QTGVDNPGHP FIKTVGMVAG DEETYEVFAE
130 140 150 160 170 180
LFDPVIQERH NGYNPRTMKH VTDLDASKIK FGHFDERYVL SSRVRTGRSI RGLSLPPACT
190 200 210 220 230 240
RAERREVEKV TVEALNGLTG DLSGRYYRLS EMTEKEQQQL IDDHFLFDKP VSPSLTAAGM
250 260 270 280 290 300
ARDWPDARGI WHNNEKTFLI WINEEDHTRV ISMEKGGNMK RVFERFCRGL KEVERLIQER
310 320 330 340 350 360
GWEFMWNERL GYILTCPSNL GTGLRAGVHI KLPLLSKDSR FPKILENLRL QKRGTGGVDT
370 380 390 400 410
AATANVFDIS NLDRLGKSEV ELVQLVIDGV NYLIDCERRL EKGQDIRIPS PVPQFRH
|
P70079 in FASTA format |
|
ExPASy Home page
SIB Switzerland